Hyperthermia

Hyperthermia is rapidly becoming the fourth modality of cancer treatment, at least a useful adjuvant to radiation therapy, chemotherapy or surgery; at best, a new therapeutic form that, properly used, may open new horizons in the fight against this dreadful disease. The staging is still primitive. The devices used are after laboratory improvisations, and lack the precision and definition of treatment fields that will allow mass use of the modality. Clinical practices are limited to the procedural evaluations of a few pioneer groups, and basic understanding of its mechanism of action, although progressing by leaps and bounds is still short of perfection. The challenge and the promise are there, and because of this, engineers, physicists, biologists, physiologists and clinicians from different specialties have a basic need for interaction, both in terms of exchange of scientific information and peer review of results and clinical trials. To satisfy this need, to act as a clearinghouse of knowledge and a forum for discussion, the North American Hyperthermia Group (NAHG) has been formed. The meeting in Detroit in August 1981 represents the first gathering of the group, to be followed by a second in Salt Lake City in April 1982. The Detroit meeting was mostly devoted to the physiology and clinical problems associated with Hyperthermia, although physics and basic thermobiology were also discussed. 75 scientists attended the meeting and 30 papers were presented. A selection of these papers represents this volume, offered more as a statement of problems than a final solution to them. Front Matter....Pages i-x Identification of Viable Regions in “In Vitro” Spheroidal Tumors: A Mathematical Investigation....Pages 1-7 Hyperthermia for Malignant Disease — A History of Medicine Note — The Work of Georges Lakhovsky....Pages 9-10 Sequential Regional Hyperthermia: A Possible Answer for the Treatment of Cancer....Pages 11-22 Effects of Hyperthermia and Hyperglycemia on the Metastases Formation and on Survival of Rat Bearing W256 Carcinosarcoma....Pages 23-42 Computer Controlled Hyperthermia Unit for Cancer Therapy....Pages 43-48 Impact of Localized Microwave Hyperthermia on the Oxygenation Status of Malignant Tumors....Pages 49-55 Cardiovascular and Oxygenation Changes During Whole Body Hyperthermia....Pages 57-70 Recent Trends in the Cancer Multistep Therapy Concept....Pages 71-85 Results of a Phase I/II Clinical Trial of Fractionated Hyperthermia in Combination with Low Dose Ionizing Radiation....Pages 87-97 Adjuvant Hyperthermia in the Irradiation of Metastatic Tumor Masses Utilizing 2450 MHz Microwaves....Pages 99-107 Further Studies on the Nature of the Biphasic Radiation Survival Response of Chinese Hamster Cells V-79-753B to Molecular Oxygen....Pages 109-122 Oxygen Effects in Radiobiology....Pages 123-144 Local Ionizing Radiation with and without Microwave Induced Hyperthermia in Superficial Malignant Tumors in Brain....Pages 145-146 Oxygen, Hydrogen Donors and Radiation Response....Pages 147-175 Differential Response to Heat of Metastatic and Non-Metastatic Rat Mammary Tumors....Pages 177-184 Computer Modeling of Tumor Hyperthermia (A Dynamic Lumped Parameter Model)....Pages 185-189 Back Matter....Pages 191-192