Hydrogen Peroxide Metabolism in Health and Disease (Oxidative Stress and Disease)

"Much of the biology of oxidative stress and oxidative signalling centres on the generation and handling of hydrogen peroxide. The overall aim for this book would be to provide an insightful and useful forum to assist with the understanding of the relevance of hydrogen peroxide generation and how this is managed in human biology. The target audience would be those who currently have an interest in the generation of ROS, but who do not have expertise in chemistry, as well as those experts in the chemistry of oxidative stress, but without detailed understanding of the biologically relevant setting. We would aim to bridge the gap in understanding between chemistry and biology."--Provided by publisher Content: Hydrogen peroxide, a molecule with a Janus face. Its history, chemistry and biology / Wilhelm H. Koppenol -- Visualization of H2O2 and other peroxides in chemiluminescence and bioluminescence / Etelvino JH Bechara, Wilhelm J. Baader, and Cassius V. Stevani -- Comparative analysis of hydrogen peroxide and peroxynitrite reactivity with thiols / Madia Trujillo, Sebastián Carballal, Ari Zeida, and Rafael Radi -- Influence of CO2 on hydroperoxide metabolism / Daniela Ramos Truzzi and Ohara Augusto -- Peroxides and protein oxidation / Michael J. Davies -- Catalysis by peroxiredoxins at high temporal and structural resolution / Leslie B. Poole and P. Andrew Karplus -- Mitochondrial hydrogen peroxide as a redox signal / Elizabeth C. Hinchy and Michael P. Murphy -- Quinone toxicity : involvement of reactive oxygen species / Rex Munday -- NADPH oxidases (NOXes) and reactive oxygen in viral infections, with emphasis on influenza / Shivaprakash Gangappa, Amelia R. Hofstetter, Becky A. Diebold, and J. David Lambeth -- The neutrophil NADPH oxidase / William M. Nauseef -- Myeloperoxidase : unleashing the power of hydrogen peroxide / Louisa Forbes and Anthony J. Kettle -- Myeloperoxidase-derived oxidants hypochlorous acid and chloramines : microbicidal marvels and inflammatory mischief makers / Margreet C.M. Vissers, Juliet Pullar, and Alexander Peskin -- Peroxidase-derived oxidants hypobromous acid (HOBr) and hypothiocyanous acid (HOSCN) / Clare L. Hawkins and Benjamin S. Rayner -- Hydrogen peroxide-dependent redox signaling : basic concepts and unanswered questions / Mark Hampton -- Regulation of H2O2 transport across cell membranes / Gerd Patrick Bienert, Iria Medraño-Fernandez, and Roberto Sitia -- H2O2, thioredoxin and signaling / Elias S.J. Arnér -- H2O2-induced ERK 1/2 MAP kinases activity mediates the interaction between Thioredox-in-1 and the thioredoxin interacting protein / Hugo P. Monteiro, Fernando T. Ogata, and Arnold Stern -- Interactions between Nrf2 activation and glutathione in the maintenance of redox homeostasis / Henry Jay Forman, Matilde Maiorino, and Fulvio Ursini -- Roles of hydrogen peroxide in the regulation of vascular tone / Christopher P. Stanley, Ghassan J. Maghzal, and Roland Stocker. This book provides an insightful and useful forum to help understand the relevance of hydrogen peroxide generation in human biology. This book is for readers with an interest in the generation of ROS, but without expertise in chemistry, and experts in oxidative stress, but without detailed understanding of the biologically relevant setting.