Human medicinal agents from plants : developed from a symposium sponsored by the Division of Agricultural and Food Chemistry at the 203rd National Meeting of the American Chemical Society, San Francisco, California, April 5-10, 1992

Content: Plant-derived natural products in drug discovery and development : an overview / Manuel F. Balandrin, A. Douglas Kinghorn, and Norman R. Farnsworth -- Tropical forest biodiversity and the potential for new nedicinal plants / Alwyn H. Genry -- Phytomedicines in Western Europe : potential impact and herbal medicine in the United States / Varro E. Tyler -- Biological and chemical diversity and the search for new pharmaceuticals and other bioactive natural products / James D. McChesney -- The renaissance of plant research in the pharmaceutical industry / Melanie J. O'Neill and Jane A. Lewis -- Secondary metabolism in plant tissue cultures trnsformed with Agrobacterium tumefaciens and Agrobacterium rhizogenes / G.H. Neil Towers and Shona Ellis -- Role of plants in the National Cancer Institute drug discovery and development program / Gordon M. Cragg, Michael R. Boyd, John H. Cardellina II, Michael R. Grever, Saul A. Schepartz, Kenneth M. Snader, and Matthew Suffness -- Logistics and politics in plant drug discovery : the other end of the spectrum / Djaja Doel Soejarto -- Simple bench-top bioassays (brine shrimp and potato discs) for the discovery of plant antitumor compounds : review of recent progress / Jerry L. McLaughlin, Ching-jer Chang, and David L. Smith -- Taxol, an exciting anticancer drug from Taxus brevifolia : an overview / David G.I. Kingston -- Camptothecin and analogues : synthesis, biological in vitro and in vivo activities, and clinical possibilites / Monroe E. Wall and Mansukh C. Wani -- Antineoplastic agents and their analogues from Chinese traditional medicine / Kuo-Hsiung Lee -- Novel strategies for the discovery of plant-derived anticancer agents / Geoffrey A. Cordell, Norman R. Farnsworth, Christopher W.W. Beecher, Djaja Doel Soejarto, A. Douglas Kinghorn, John M. Pezzuto, Monroe E. Wall, Mansukh C. Wani, Daniel M. Brown, Melanie J. O'Neill, Jane A. Lewis, R. Murray Tait, and Timothy J.R. Harris -- Cancer chemopreventive agents : from palnt materials to clinical intervention trials / john M. Pezzuto -- National Cancer Institute intramural research on human immunodeficiency virus inhibitory and antitumor plant natural products / John H. Carellina II, Kirk R. Gustafson, John A. Beutler, Tawnya C. McKee, Yali F. Halloc, Richard W. Fuller, and Michael R. Boyd -- Discovery and development of novel prototype antibiotics for opportunistic infections related to acquired immunodeficiency syndrome / Alice M. Clark and Charles D. Hufford -- Artemisia annua : from weed to respectable antimalarial plant / Daniel L. Klayman -- Search for molluscicidal and larvicidal agents from plants / M. Maillard, A. Marston, and K. Hostettmann -- Algal secondary metabolites and their pharmaceutical potential / Gabriele M. Konig and Anthony D. Wright -- Activation of the isotypes of protein kinase C and other kinases by phorbol esters of different biological activities / Fred J. Evans and Nahed M. Hassan -- Bioactive organosulfur compounds of garlic and garlic products : role in reducing blood lipids / Larry D. Lawson -- Rohitukine and forskolin : second-generation immunomodulatory, intraocular-pressure-lowering, and cardiotonic analogues / Noel J. De Souza.
Covers the discovery, development, use and potential use, and regulation of plant-derived drugs. Describes ongoing research for prospective natural drugs with anticancer and anti-infective activities. Features some highly promising compounds, including artemisinin, camptothecin, forskolin, and taxol. Includes coverage of biologically active constituents of terrestrial and marine plants. Also addresses the effects of the destruction of rain forests on drug discovery. This work covers the current importance of plant-derived drugs in the United States and their discovery, use and potential use for certain diseases, their development and their regulation. It includes coverage of the effects of the destruction of rain forests on drug discovery.