Human malignancies new approaches to diagnosis and therapy ; 26 tab. ; [based on the proceedings of a symposium

To scientists, oncology means research on the disease of cancer. The connection between basic research and clinical oncology, however, is not always very clear. Basic research sometimes appears to be an art that is practiced for its own sake and admired for its perfection. The clinician wishes to interpret the issues addressed by basic research, as he is eager to obtain answers to the questions that clinical oncology leaves open. These are, among others, questions as to the etiology and pathogenesis of neoplasma in human beings. In spite of all the technological advances during the past 10 years, the guidelines for new treatments of human leukemias and tumors are still unsatisfactory. The dialogue between researchers and clinicians must never cease, so that these questions can be formulated in such a way that science may be able to answer them. Both parties should cooperate whenever this is useful and possible. Prospectively planned clinical trials on the diagnosis and therapy of neoplasias offer a good opportunity for research involving patients. Tumor and/or blood tests run by reference laboratories on a great number of patients with the same diagnosis can lead to clinically relevant basic research. Using clinical studies in basic research programs permits us to trace missing pieces in the puzzle of cancer and put them into place. Front Matter....Pages I-XI Front Matter....Pages 1-1 DNA Analysis as a Tool for Determination of Clonality and Lineage in Acute Leukaemias....Pages 3-10 Differentiation of the Major Human Tumor Groups Using Monoclonal Antibodies Specific for Individual Intermediate Filament Proteins....Pages 11-26 Serological Diagnosis of Neoplastic Diseases....Pages 27-34 Macrophages in the Stroma of Malignant Tumors....Pages 35-45 Biological Markers in the Classification and Diagnosis of Disorders of the Human Breast....Pages 46-55 Front Matter....Pages 57-57 Advances in the Chemotherapeutic Treatment of Childhood Leukemia....Pages 59-65 Coexpression of Interleukin 2 and HTLY III Messenger RNA in Patients with Acquired Immune Deficiency Syndrome....Pages 66-79 New Approaches to Cancer Immunotherapy....Pages 80-91 Functional Properties and Application of Ganglioside Antibodies to Patients with Malignant Melanoma....Pages 92-97 Therapeutic Application of Iodine-131 Labelled Monoclonal Anti-CEA/CA 19-9, and OC 125 Antibodies....Pages 98-118 Metaiodobenzylguanidine in Diagnosis and Treatment of Childhood Neuroblastoma....Pages 119-131 Successful Application of a Virus-Modified Tumor Vaccine for Anti-Metastatic Cancer Immunotherapy....Pages 132-142 Closing Remarks....Pages 143-145 Back Matter....Pages 147-149 The interaction between basic research and clinical oncology is featured in this up-to-date report on the diagnosis and therapy of human malignancies. The contributions stem from both clinicians and researchers and highlight immunotherapy, chemotherapy, HIV-infections, immunoimaging, and cancer genotyping. It is hoped that these results will lead to future cooperation and promote joint projects in the field