Human Interferon: Production and Clinical Use (Advances in Experimental Medicine and Biology, 110)

Front Matter....Pages i-viii Large Scale Production and Properties of Human Leukocyte Interferon Used in Clinical Trials....Pages 1-13 New Microcarriers for the Large Scale Production of Anchorage-Dependent Mammalian Cells....Pages 15-23 Effect of Low Levels of Cyclic Ribonucleotides on Mitogen and Virus Induced Production of Interferon....Pages 25-35 Production of Interferon in Human Cell Cultures by a New, Potent Viral Inducer....Pages 37-53 Human Interferon: Large Scale Production in Embryo Fibroblast Cultures....Pages 55-60 Factors Influencing Production of Interferon by Human Lymphoblastoid Cells....Pages 61-74 Antigenic Properties and Heterospecific Antiviral Activities of Human Leukocyte Interferon Species....Pages 75-84 Membrane Alterations Following Interferon Treatment....Pages 85-99 Selection of New Human Foreskin Fibroblast Cell Strains for Interferon Production....Pages 101-118 Tissue Culture Models of In Vivo Interferon Production and Action....Pages 119-131 Thermal and Vortical Stability of Purified Human Fibroblast Interferon....Pages 133-152 Interferon Assay Anomaly Variation of Interferon Response with Cell Type and Sialic Acid Content....Pages 153-157 Interferon Therapy for Neoplastic Diseases in Man In Vitro and In Vivo Studies....Pages 159-174 Results of a Five-Year Study of the Curative Effect of Double Stranded Ribonucleic Acid in Viral Dermatoses and Eye Diseases....Pages 175-191 The Possibility of Interferon Production in Tumors....Pages 193-199 The Future of Interferon as an Antiviral Drug....Pages 201-211 Considerations in Our Search for Interferons for Clinical Use....Pages 213-216 Back Matter....Pages 217-221