Human Herpesviruses HHV-6A, HHV-6B and HHV-7: Diagnosis and Clinical Management (Volume 12) (Perspectives in Medical Virology, Volume 12)

Completely revised and updated, __Human Herpesviruses HHV-6A, HHV-6B & HHV-7, Third Edition__, delivers a contemporary and thorough review of HHV-6, beginning with foundational explorations of classification, molecular biology, and chromosomal integration of the virus, through to clinical details, including pathologic features of infection, and clinical effects on various organ systems. The work now includes coverage of HHV-7, a virus that remains underestimated in transplant reactivation, seizures, and encephalitis. The book examines the role of HHV-6 in myriad diseases, including cognitive disorders following bone marrow transplant, mesial temporal lobe epilepsy, multiple sclerosis, autoimmune disease, encephalitis, Hodgkin's disease lymphoma (HHV-6B), and glioma (HHV-6A). Descriptions of current and novel molecular and serological diagnostic assays, along with detailed protocols, are included to aid researchers and clinicians in discriminating potential false positives originating from chromosomally integrated HHV-6, and in differentiating between active and latent infection. __Human Herpesviruses HHV-6A, HHV-6B & HHV-7, Third Edition__ is a valuable reference for both clinical and basic scientists, including epidemiologists, virologists, practicing clinicians, infectious disease specialists, pathologists, and all scientists entering the field of herpes virus research. The work is a practical and thorough resource for a foundational understanding of HHV-6 and HHV-7, while providing a cutting-edge translational and clinical reference to those looking to understand and diagnose associated viral diseases. . Delivers the latest molecular diagnostic tests, the present-day gold standard for monitoring HHV-6. Provides expert analysis of T-cell immune response against HHV-6 . Presents tools for differential diagnosis in HHV-6 viral infections. Includes new information on the previously-largely-unknown biological consequences of ciHHV-6 . Offers coverage of new discoveries relating to HHV-7 Content: Front-matter , Pages i,iii Copyright , Page iv List of Contributors , Pages xiii-xiv , Dharam V. Ablashi, Henri Agut, Bridgette Jeanne Billioux, Francesco Broccolo, L. Maximilian Buja, J. Mauricio Calvo-Calle, John R. Crawford, Leon G. Epstein, Louis Flamand, Agnès Gautheret-Dejean, Steven Jacobson, Yoko Kano, Anthony L. Komaroff, Gerhard R.F. Krueger, Uwe Kuehl, Roberto Alvarez Lafuente, Dirk Lassner, Irmeli Lautenschlager, Jin-Mei Li, Mario Luppi, John J. Millichap, et al. Foreword , Pages xv-xvi , Philip E. Pellett Foreword , Pages xvii-xviii , Yoshizo Asano Dedication , Page xix , Louis Flamand, Irmeli Lautenschlager, Gerhard R.F. Krueger, Dharam V. Ablashi Chapter 1 - HHV-6A and HHV-6B Officially Classified as Distinct Viruses , Pages 1-8 , Joshua C. Pritchett, Dharam V. Ablashi Chapter 2 - Practical Diagnostic Procedures for HHV-6A, HHV-6B, and HHV-7 , Pages 9-34 , Agnès Gautheret-Dejean, Henri Agut Chapter 3 - Pathologic Features of HHV-6A, HHV-6B, and HHV-7 Infection (Light and Electron Microscopy) , Pages 35-67 , Gerhard R.F. Krueger, Irmeli Lautenschlager Chapter 4 - HHV-6A, HHV-6B, and HHV-7 in Febrile Seizures and Status Epilepticus , Pages 69-80 , Leon G. Epstein, John J. Millichap Chapter 5 - HHV-6A, HHV-6B, and HHV-7 in Encephalitis , Pages 81-98 , Joseph Ongrádi, Balázs Stercz, Tetsushi Yoshikawa, Dharam V. Ablashi Chapter 6 - Cognitive Dysfunction from HHV-6A and HHV-B , Pages 99-122 , Danielle M. Zerr, Anthony L. Komaroff Chapter 7 - HHV-6 and Multiple Sclerosis , Pages 123-142 , Bridgette Jeanne Billioux, Roberto Alvarez Lafuente, Steven Jacobson Chapter 8 - Human Herpes Virus 6B in Mesial Temporal Lobe Epilepsy , Pages 143-152 , Pitt Niehusmann, Jin-Mei Li, Dong Zhou Chapter 9 - HHV-6B and HHV-7 in Exanthema Subitum and Related Skin Diseases , Pages 153-166 , Tetsushi Yoshikawa Chapter 10 - HHV-6A and HHV-6B in Autoimmune Disease , Pages 167-178 , Francesco Broccolo Chapter 11 - HHV-6A and HHV-6B in Drug-Induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms , Pages 179-200 , Descamps Vincent, Mikoko Tohyama, Yoko Kano, Tetsuo Shiohara Chapter 12 - HHV-6A and HHV-6B in Solid Organ Transplantation , Pages 201-215 , Irmeli Lautenschlager, Raymund R. Razonable Chapter 13 - HHV-6A and HHV-6B in Recipients of Hematopoietic Cell Transplantation , Pages 217-234 , Danielle M. Zerr, Masao Ogata Chapter 14 - The Immune Response to HHV-6 , Pages 235-249 , J. Mauricio Calvo-Calle, Lawrence J. Stern Chapter 15 - Chromosomally Integrated HHV-6 , Pages 251-265 , Mario Luppi, Leonardo Potenza, Guillaume Morissette, Louis Flamand Chapter 16 - HHV-6 and HHV-7 in Cardiovascular Diseases and Cardiomyopathies , Pages 267-280 , Dirk Lassner, Gerhard R.F. Krueger, L. Maximilian Buja, Uwe Kuehl Chapter 17 - HHV-6 in Lymphohematopoietic Diseases , Pages 281-296 , Sylvie Ranger-Rogez Chapter 18 - HHV-6A and HHV-6B in Cancer , Pages 297-310 , John R. Crawford Chapter 19 - Treating HHV-6 Infections: The Laboratory Efficacy and Clinical Use of Anti-HHV-6 Agents , Pages 311-331 , Joshua C. Pritchett, Lieve Naesens, Jose Montoya Index , Pages 333-341

Completely revised and updated, Human Herpesviruses HHV-6A, HHV-6B & HHV-7, Third Edition, delivers a contemporary and thorough review of HHV-6, beginning with foundational explorations of classification, molecular biology, and chromosomal integration of the virus, through to clinical details, including pathologic features of infection, and clinical effects on various organ systems. The work now includes coverage of HHV-7, a virus that remains underestimated in transplant reactivation, seizures, and encephalitis.

The book examines the role of HHV-6 in myriad diseases, including cognitive disorders following bone marrow transplant, mesial temporal lobe epilepsy, multiple sclerosis, autoimmune disease, encephalitis, Hodgkin's disease lymphoma (HHV-6B), and glioma (HHV-6A). Descriptions of current and novel molecular and serological diagnostic assays, along with detailed protocols, are included to aid researchers and clinicians in discriminating potential false positives originating from chromosomally integrated HHV-6, and in differentiating between active and latent infection.

Human Herpesviruses HHV-6A, HHV-6B & HHV-7, Third Edition is a valuable reference for both clinical and basic scientists, including epidemiologists, virologists, practicing clinicians, infectious disease specialists, pathologists, and all scientists entering the field of herpes virus research. The work is a practical and thorough resource for a foundational understanding of HHV-6 and HHV-7, while providing a cutting-edge translational and clinical reference to those looking to understand and diagnose associated viral diseases.

• Delivers the latest molecular diagnostic tests, the present-day gold standard for monitoring HHV-6
• Provides expert analysis of T-cell immune response against HHV-6
• Presents tools for differential diagnosis in HHV-6 viral infections
• Includes new information on the previously-largely-unknown biological consequences of ciHHV-6
• Offers coverage of new discoveries relating to HHV-7 Completely revised and updated, Human Herpesviruses HHV-6A, HHV-6B & HHV-7, Third Edition, delivers a contemporary and thorough review of HHV-6, beginning with foundational explorations of classification, molecular biology, and chromosomal integration of the virus, through to clinical details, including pathologic features of infection, and clinical effects on various organ systems. The work now includes coverage of HHV-7, a virus that remains underestimated in transplant reactivation, seizures, and encephalitis. The work now includes coverage of HHV-7, a virus that remains underestimated in transplant reactivation, seizures, and encephalitis The book examines the role of HHV-6 in myriad diseases, including cognitive disorders following bone marrow transplant, mesial temporal lobe epilepsy, multiple sclerosis, autoimmune disease, encephalitis, Hodgkins disease lymphoma (HHV-6B), and glioma (HHV-6A). The work now includes coverage of HHV-7, a virus thatremains underestimated in transplant reactivation, seizures, and encephalitis