HPV Infection in Head and Neck Cancer (Recent Results in Cancer Research Book 206)

This book is exceptional in presenting an interdisciplinary approach to the subject of human papillomavirus (HPV) infection in the context of head and neck cancer. Leading experts in the field discuss the epidemiology and molecular biology of HPV-positive head and neck squamous cell carcinoma, HPV testing, the nonsurgical and surgical treatment of HPV-positive tumors, predictive factors for outcome and quality of life, and ongoing trials on the effectiveness of vaccination in disease prevention. It also provides recommendations for testing, diagnosis treatment and vaccination. Otolaryngologists, head and neck surgeons, medical oncologists, radiation oncologists, molecular biologists and pathologists will find this book a valuable resource. Front Matter....Pages i-vi Front Matter....Pages 1-1 HPV in Head and Neck Cancer—30 Years of History....Pages 3-25 Epidemiology of HPV-Positive Tumors in Europe and in the World....Pages 27-35 Molecular Patterns and Biology of HPV-Associated HNSCC....Pages 37-56 HPV Integration in Head and Neck Squamous Cell Carcinomas: Cause and Consequence....Pages 57-72 Risk Factors for Oral Infection with Human Papillomavirus....Pages 73-85 Front Matter....Pages 87-87 HPV-Related Head and Neck Squamous Cell Carcinomas....Pages 89-100 HPV Testing of Head and Neck Cancer in Clinical Practice....Pages 101-111 Variation of HPV Subtypes with Focus on HPV-Infection and Cancer in the Head and Neck Region....Pages 113-122 Tumor Staging and HPV-Related Oropharyngeal Cancer....Pages 123-133 Front Matter....Pages 135-135 Human Papillomavirus (HPV): A Criterion for Therapeutic Decision in Squamous Cell Carcinoma of the Head and Neck?....Pages 137-147 Systemic Treatment in HPV-Induced Recurrent or Metastatic HNSCC....Pages 149-160 Optimizing Radiotherapy in HPV-Associated Oropharyngeal Cancer Patients....Pages 161-171 Should We De-escalate the Treatment for HPV-Positive Tumors?....Pages 173-181 Front Matter....Pages 183-183 The Role of Conventional Surgery in Oropharyngeal Cancer....Pages 185-195 The Role of Surgery in the Management of Recurrent Oropharyngeal Cancer....Pages 197-205 TORS in HPV-Positive Tumors—The New Standard?....Pages 207-218 Front Matter....Pages 219-219 Risk Groups for Survival in HPV-Positive and HPV-Negative OPSCC....Pages 221-231 Predictive Factors for Outcome and Quality of Life in HPV-Positive and HPV-Negative HNSCC....Pages 233-242 Cancer Immunology and HPV....Pages 243-248 Front Matter....Pages 249-249 Update on De-intensification and Intensification Studies in HPV....Pages 251-256 Front Matter....Pages 249-249 Vaccination Expectations in HNSCC....Pages 257-267 Epidemiology And Molecular Biology Of Hpv Positive Hnscc -- Hpv Testing -- Non-surgical Treatment Of Hpv Positive Tumours -- Surgical Treatment Of Hpv Positive Tumours -- Predictive Factors For Outcome And Quality Of Life In Hpv Positive And Hpv Negative -- Hpv -- Prevention Vaccination, Ongoing Trials. Wojciech Golusiński, C. René Leemans, Andreas Dietz, Editors. Includes Bibliographical References.