How Helminths Alter Immunity to Infection (Advances in Experimental Medicine and Biology Book 828)

"Helminth infections are common, cause considerable pathology, and alter a host's immune profile. This can have important consequences not only on the host's ability to control a helminth infection, but also on their ability to control unrelated infections. In endemic areas, understanding how helminth infection influences the outcome of common infectious diseases and changes the efficacy of childhood vaccination programs is an important public health question. This book reviews how host immunity to helminths alters our ability to respond to the major pathogens that exist in helminth endemic regions. Current understanding of how helminths alter important but relatively neglected contributors to the host's anti-helminth immune responses are addressed, namely host antibody responses and how maternal infection may alter a child's immune development. These are discussed in relation to the control of helminth infection and unrelated infections. Also covered are how helminth infections alter the host's ability to control TB, HIV and malarial infections along with neglected bacterial infections, such as cholera, and how endemic helminth infections are likely to alter our ability to respond to life-saving vaccination strategies"-- Publisher's description "Helminth infections are common, cause considerable pathology, and alter a host's immune profile. This can have important consequences not only on the host's ability to control a helminth infection, but also on their ability to control unrelated infections. In endemic areas, understanding how helminth infection influences the outcome of common infectious diseases and changes the efficacy of childhood vaccination programs is an important public health question. This book reviews how host immunity to helminths alters our ability to respond to the major pathogens that exist in helminth endemic regions. Current understanding of how helminths alter important but relatively neglected contributors to the host's anti-helminth immune responses are addressed, namely host antibody responses and how maternal infection may alter a child's immune development. These are discussed in relation to the control of helminth infection and unrelated infections. Also covered are how helminth infections alter the host's ability to control TB, HIV and malarial infections along with neglected bacterial infections, such as cholera, and how endemic helminth infections are likely to alter our ability to respond to life-saving vaccination strategies."--[Source inconnue] Front Matter....Pages i-x The Role of Antibody in Parasitic Helminth Infections....Pages 1-26 Maternal Helminth Infections....Pages 27-48 Helminth- M. Tb Co-Infection....Pages 49-74 Bacterial Infections and Vaccines....Pages 75-98 Helpful or a Hindrance: Co-infections with Helminths During Malaria....Pages 99-129 Immune System Modulation by Helminth Infections: Potential Impact on HIV Transmission and Disease Progression....Pages 131-149 Back Matter....Pages 151-152 The role of antibody in parasitic helminth infections Maternal helminth infections Helminth-M. tb co-infection Bacterial infections and vaccines Helpful or a hindrance: co-infections of helminth during malaria Immune system modulation by helminth infections: potential impact on HIV transmission and disease progression.