Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis: GRAVANIS:HORMONES NEURO O-BK

As life expectancy increases and population ages, the already enormous impact of neurodegeneration on society will become even larger without better prevention and treatment. Developing strategies to prevent degeneration of neurons and to promote a healthy nervous system is, thus, critical. The development of pharmacological agents that would increase production of new neurons was recently facilitated by the identification of the hormonal regulators of various steps of adult neurogenesis. The proposed book is writen by a group of top world experts involved in the study of the mechanisms of hormonal control of brain damage and repair. The effects of thyroid and steroid hormones (estrogens, androgens, progestins, gluco-mineralo-corticoids, various neurosteroids) or polypeptide hormones (CRF, urocortins, somatostastin, GH/IGF, leptin, prolactin, PACAP, erythropoetin) on neuronal survival and neurogenesis in various neurodegenerative conditions and in brain aging will be discussed in detail. The proposed book is unique because it gives a comprehensive account of the neuroprotective and neurogenic effects of steroid and polypeptide hormones. Furthermore, new pharmacological approaches for treatment of neurodegenerative conditions are presented, based on the neuroprotective and neurogenic properties of natural and synthetic hormones. Content: Chapter 1 Interactions of Estradiol and Insulin?Like Growth Factor?I in Neuroprotection: Implications for Brain Aging and Neurodegeneration (pages 1–11): Maria?Angeles Arevalo, Luis M. Garcia?Segura and Inigo Azcoitia Chapter 2 Structure–Nongenomic Neuroprotection Relationship of Estrogens and Estrogen?Derived Compounds (pages 13–28): James W. Simpkins, Kun Don Yi, Evelyn Perez and Douglas Covey Chapter 3 Progestins and Neuroprotection: Why the Choice of Progestin Matters (pages 29–40): Meharvan Singh Chapter 4 Endogenous and Synthetic Neurosteroids in the Treatment of Niemann–Pick Type C Disease (pages 41–60): Prof. Dr. Synthia H. Mellon, Wenhui Gong and Marcus D. Schonemann Chapter 5 Glucocorticoids, Developmental “Programming,” and the Risk of Affective Dysfunction (pages 61–101): Bayanne Olabi and Jonathan Seckl Chapter 6 Regulation of Structural Plasticity and Neurogenesis during Stress and Diabetes; Protective Effects of Glucocorticoid Receptor Antagonists (pages 103–120): Paul J. Lucassen, Carlos P. Fitzsimons, Erno Vreugdenhil, Pu Hu, Charlotte Oomen, Yanina Revsin, Marian Joels and Edo Ronald de Kloet Chapter 7 Neuroactive Steroids and Peripheral Neuropathy (pages 121–135): Roberto C. Melcangi, Silvia Giatti, Marzia Pesaresi, Donatella Caruso and Marc J. Tetel Chapter 8 Neuroprotective and Neurogenic Properties of Dehydroepiandrosterone and its Synthetic Analogs (pages 137–154): Ioannis Charalampopoulos, Iakovos Lazaridis and Achille Gravanis Chapter 9 Neurosteroids and Pain (pages 155–170): Christine Patte?Mensah, Laurence Meyer, Veronique Schaeffer, Cherkaouia Kibaly and Ayikoe G. Mensah?Nyagan Chapter 10 The Insulin/IGF?1 System in Neurodegeneration and Neurovascular Disease (pages 171–187): Przemyslaw (Mike) Sapieha and Lois Smith Chapter 11 Leptin Neuroprotection in the Central Nervous System (pages 189–203): Feng Zhang, Suping Wang, Armando P. Signore, Zhongfang Weng and Jun Chen Chapter 12 Somatostatin and Neuroprotection in Retina (pages 205–226): Kyriaki Thermos Chapter 13 Neurotrophic Effects of PACAP in the Cerebellar Cortex (pages 227–236): Anthony Falluel?Morel, Hubert Vaudry, Hitoshi Komuro, Dariusz C. Gorecki, Ludovic Galas and David Vaudry Chapter 14 The Corticotropin?Releasing Hormone in Neuroprotection (pages 237–249): Christian Behl and Angela Clement Chapter 15 Neuroprotective and Neurogenic Effects of Erythropoietin (pages 251–263): Helmar C. Lehmann and Ahmet Hoke Chapter 16 Thyroid Hormone Actions on Glioma Cells (pages 265–279): Min Zhou, Harold K. Kimelberg, Faith B. Davis and Paul J. Davis Chapter 17 Gonadal Hormones, Neurosteroids, and Clinical Progestins as Neurogenic Regenerative Agents: Therapeutic Implications (pages 281–303): Lifei Liu and Roberta Diaz Brinton Chapter 18 Gonadotropins and Progestogens: Obligatory Developmental Functions during Early Embryogenesis and their Role in Adult Neurogenesis, Neuroregeneration and Neurodegeneration (pages 305–329): Craig S. Atwood and Sivan Vadakkadath Meethal Chapter 19 Human Neural Progenitor Cells: Mitotic and Neurogenic Effects of Growth Factors, Neurosteroids, and Excitatory Amino Acids (pages 331–345): Masatoshi Suzuki, Jacalyn McHugh and Narisorn Kitiyanant Chapter 20 Corticosterone, Dehydroepiandrosterone, and Neurogenesis in the Adult Hippocampus (pages 347–365): Joe Herbert and Scarlet Bella Pinnock