Hormonal Regulation of Mammary Tumors : Volume II: Peptide and Other Hormones

The concept that hormones influence tumor growth originated in 1889 with the proposal of Albert Schinzinger who suggested that breast cancer is related to the ovaries. Several years later, Sir George Beatson observed that remission of disseminated breast cancer could be achieved in premenopausal patients by performing bilateral oophorectomy. As a result of the contri­ butions of Hedley Atkins, Charles Huggins and others, additive and ablative hormonal therapies have been widely used for the treatment of advanced breast cancers for several decades. Model systems to study the effects of hormones on growth and regression of breast tumors have been available for many years; however, the complexities of the hormonal environment have rendered in vivo studies difficult in man and experimental animals. Recently, the availability of long-term cultures of breast cancer cells has stimulated many investigators to use these cell lines to unravel the mechanisms of hormone action. Because of the extreme diversity and complexity of advances regarding the endocrinology of the breast and breast cancers, a multi-authored review was deemed necessary. It has been gratifying to receive contributions from many noted scholars. In Volume I of this monograph, the influence of steroid hormones and their antagonists upon normal and neoplastic tissues of the mammary gland are presented. In Volume II, the effects of peptide and other hormones are reviewed. Front Matter....Pages i-xvi Role of Prolactin or Placental Lactogen in Mammary Tumor Development in Experimental Animals....Pages 1-24 Prolactin and Prolactin Receptors in Tumor Development, Growth and Cellular Functions....Pages 25-62 Studies of Prolactin Receptors and the Possible Proliferative Role of Prolactin and Other Pituitary Factors in Human Breast Tumor Cells....Pages 63-76 Mode of Action of Prolactin on Normal and Neoplastic Mammary Tissues....Pages 77-87 Growth Factors for Hormone-Sensitive Tumor Cells....Pages 88-122 Primary and Permissive Actions of Insulin in Breast Cancer....Pages 123-137 Effect of Thyroid Hormones on Mammary Tumor Induction and Growth....Pages 138-154 Mode of Cyclic AMP Action in Growth Control....Pages 155-177 Prostaglandins, Fatty Acids and Phospholipids in Normal and Neoplastic Breast Tissues....Pages 178-204 Polyamines in Normal and Neoplastic Growth of Mammary Gland....Pages 205-228 Hormonal Regulation of Casein Gene Expression in Normal and Neoplastic Cells in Murine Mammary Glands....Pages 229-283