Hormonal carcinogenesis V : [proceedings of the Fifth International Symposium on Hormonal Carcinogenesis

Information Gathered From Cell-free Systems, Cell Cultures, Animal Models, And Human Studies, Together Will (1) Provide Important Insights To Our Understanding Of Hormonal Cancer Causation, Development, And Prevention; (2) Be The Primary Objective Of These Symposia. Symposium Address -- State Of The Art Speakers. Cellular Origins Of Endocrine-related Cancers. Mitotic Kinases, Centrosome Amplification, And Genomic Instability. New Developments In Steroid Receptor Interactions. Risk Assessment And Relevant Early Biomarkers. Novel Strategies For Preventing And Treatment Of Endocrine-related Cancers. Hormone Dependency Versus Hormone Independency. Emerging Fields : Hormones And Colorectal And Lung Cancers -- Human Derived Studies. Breast Cancer. Lung Cancer. Reproductive Endometrial Cancer. Prostate Cancer --cell/molecular Biology And Hormone Metabolism. Animal Models. Breast Cancer. Endometrial Cancer. Prostate Cancer. Liver Cancer. Hormone Metabolism. Jonathan J. Li ... [et Al.], Editors. Includes Bibliographical References And Index. Contents......Page 12 Contributors......Page 21 Abbreviations......Page 32 SYMPOSIUM ADDRESS......Page 42 Relevance of the Concept of Oncogene Addiction to Hormonal Carcinogenesis and Molecular Targeting in Cancer Prevention and Therapy......Page 43 STATE OF THE ART SPEAKERS......Page 54 1. What Can we Learn about Breast Cancer from Stem Cells?......Page 55 2. Ovarian Cancer: Linking Genomics to New Target Discovery and Molecular Markers — The Way Ahead......Page 61 3. Cdk1, Plks, Auroras, and Neks: The Mitotic Bodyguards......Page 79 4. Women's Health Research: Perspectives from the National Institutes of Health......Page 95 Part 1: Cellular Origins of Endocrine-related Cancers......Page 105 5. Stem Cells, Hormones, and Mammary Cancer......Page 106 6. The Origin of Estrogen Receptor α-Positive and α-Negative Breast Cancer......Page 116 7. Hormone Refractory Prostate Cancer: Lessons Learned from the PTEN Prostate Cancer Model......Page 124 Part 2: Mitotic Kinases, Centrosome Amplification, and Genomic Instability......Page 133 8. Functional Significance of Aurora Kinase A in Centrosome Amplification and Genomic Instability......Page 134 9. Centrosome-Mediated Chromosomal Instability and Steroid Hormones as Co factors in Human Papillomavirus-Associated Cervical Carcinogenesis: Small Viruses Help to Answer Big Questions......Page 144 Part 3: New Developments in Steroid Receptor Interactions......Page 153 10. Regulation of Hormone Signaling by Nuclear Receptor Interacting Proteins......Page 154 11. Dynamics of Estrogen Receptor-mediated Transcriptional Activation of Responsive Genes In Vivo: Apprehending Transcription in Four Dimensions......Page 161 12. Expression of Estrogen Receptors α and β in Early Steps of Human Breast Carcinogenesis......Page 171 Part 4: Risk Assessment and Relevant Early Biomarkers......Page 181 13. Women's Health Initiative Studies of Postmenopausal Breast Cancer......Page 182 14. Circulating Levels of Sex Steroids and Prolactin in Premenopausal Women and Risk of Breast Cancer......Page 192 15. Ovulation and Ovarian Cancer......Page 201 16. Prostate Cancer Susceptibility Loci: Finding the Genes......Page 209 Part 5: Novel Strategies for Preventing and Treatment of Endocrine-related Cancers......Page 221 17. Strategy for the Application of Therapy in Prostate Cancer......Page 222 18. Response and Resistance to the Endocrine Prevention of Breast Cancer......Page 229 19. Estrogen-Induced Breast Oncogenesis: Modulation by an Aurora Kinase Inhibitor......Page 240 Part 6: Hormone Dependency Versus Hormone Independency......Page 248 20. Castration-Recurrent Prostate Cancer Is Not Androgen-Independent......Page 249 21. Estrogen-Receptor-Related Receptors and Hormone-Dependent Cancers......Page 261 22. Androgen Receptor Coactivators and Prostate Cancer......Page 270 Part 7: Emerging Fields: Hormones and Colorectal and Lung Cancers......Page 281 23. Why Hormones Protect Against Large Bowel Cancer: Old Ideas, New Evidence......Page 282 24. Vitamin D[sub(3)] and Colorectal Cancer......Page 293 25. Estrogen-Signaling Pathways in Lung Cancer......Page 303 COMMUNICATIONS......Page 312 Session I: Human Derived Studies......Page 313 Breast Cancer......Page 314 Noninvasive Measurement of the Electrical Properties of Breast Epithelium During the Menstrual Cycle: A Potential Biomarker for Breast Cancer Risk......Page 315 Is the Mannose-6-Phosphate/Insulin-Like Growth Factor 2 Receptor Coded by a Breast Cancer Suppressor Gene?......Page 323 Her-2/neu-induced "Cytokine Signature" in Breast Cancer......Page 329 Involvement of a JAK/STAT Pathway Inhibitor: Cytokine Inducible SH2 Containing Protein in Breast Cancer......Page 338 In Silico and In Vitro Analysis of Small Breast Epithelial Mucin as a Marker for Bone Marrow Micrometastasis in Breast Cancer......Page 347 Estrogen-regulated Cut-off Values of pS2 and Cathepsin D Expression in Breast Carcinomas......Page 356 Molecular Signatures of Estrogen Receptor-Associated Genes in Breast Cancer Predict Clinical Outcome......Page 364 Comparative Analysis of SNP in Estrogen-metabolizing Enzymes for Ovarian, Endometrial, and Breast Cancers in Novosibirsk, Russia......Page 373 IRF-1 Promotes Apoptosis in p53-damaged Basal-type Human Mammary Epithelial Cells: A Model for Early Basal-type Mammary Carcinogenesis......Page 381 Lung Cancer......Page 389 Steroid Receptor and Growth Factor Receptor Expression in Human Nonsmall Cell Lung Cancers Using Cells Procured by Laser-capture Microdissection......Page 390 Reproductive Endometrial Cancer......Page 398 Blood Levels of Organochlorine Pesticide Residues and Risk of Reproductive Tract Cancer Among Women from Jaipur, India......Page 399 Prostate Cancer......Page 407 AKT Regulates Androgen Receptor-dependent Growth and PSA Expression in Prostate Cancer......Page 408 Session II: Cell/Molecular Biology and Hormone Metabolism......Page 417 Animal Models......Page 418 Expression of Selected Aurora A Kinase Substrates in Solely Estrogen-induced Ectopic Uterine Stem Cell Tumors in the Syrian Hamster Kidney......Page 419 Global Quantitative Analysis of Protein Phosphorylation Status in Fish Exposed to Microcystin......Page 427 Breast Cancer......Page 435 ERK/MAPK Regulation of the Androgen Responsiveness of Breast Cancer Cells......Page 436 Vascular Endothelial Growth Factor is a Target Gene for Estrogen Receptor and Contributes to Breast Cancer Progression......Page 443 Identification of Downstream Targets of Estrogen and c-myc in Breast Cancer Cells......Page 451 Cathepsin D Overexpressed by Cancer Cells Can Enhance Apoptosis-dependent Chemo-sensitivity Independently of Its Catalytic Activity......Page 458 A Synthetic Peptide Derived from Alpha-fetoprotein Inhibits the Estradiol-induced Proliferation of Mammary Tumor Cells in Culture through the Modulation of p21......Page 467 Hormonal Prevention of Breast Cancer: Significance of Promotional Environment......Page 473 Hormones of Pregnancy, α-Feto Protein, and Reduction of Breast Cancer Risk......Page 480 Role of Estrogens and Their Receptors in Adhesion and Invasiveness of Breast Cancer Cells......Page 488 Proteomic Analysis of Autocrine/Paracrine Effect sof Human Growth Hormone in Human Mammary Carcinoma Cells......Page 495 Endometrial Cancer......Page 503 Expression Analysis of Human Endometrial Adenocarcinoma in an Inbred Rat Model......Page 504 Amplification Studies of MET and Cdk6 in a Rat Endometrial Tumor Model and Their Correlation to Human Type I Endometrial Carcinoma Tumors......Page 511 Recurrent Chromosome 10 Aberrations and Tp53 Mutations in Rat Endometrial Adenocarcinomas......Page 518 Prostate Cancer......Page 525 Specific Properties of a C-terminal Truncated Androgen Receptor Detected in Hormone Refractory Prostate Cancer......Page 526 The Role of the Transcriptional Coactivator p300 in Prostate Cancer Progression......Page 532 Characterization of Androgen Regulation of ZEB-1 and PSA in 22RV1 Prostate Cancer Cells......Page 538 Mcl-1 is Regulated by IL-6 and Mediates the Survival Activity of the Cytokine in a Model of Late Stage Prostate Carcinoma......Page 544 Sex Hormone-binding Globulin Influences Gene Expression of LNCaP and MCF-7 Cells in Response to Androgen and Estrogen Treatment......Page 553 Inactivation of ID-1 Gene Induces Sensitivity of Prostate Cancer Cells to Chemotherapeutic Drugs......Page 561 Membrane Initiated Signaling by 1,25α-dihydroxyvitamin D[sub(3)] in LNCaP Prostate Cancer Cells......Page 569 Gonadotrophin Releasing Hormone-Based Vaccine, an Effective Candidate for Prostate Cancer and Other Hormone-sensitive Neoplasms......Page 576 Liver Cancer......Page 583 Pigment Epithelium-derived Factor is an Angiogenesis and Lipid Regulator that Activates Peroxisome Proliferator-activated Receptor α......Page 584 Hormone Metabolism......Page 591 Estrogenic Activity of the Equine Estrogen Metabolite, 4-Methoxyequilenin......Page 592 Dynamics of Oxidative Damage at Early Stages of Estrogen-dependant Carcinogenesis......Page 599 Gene Expression of 17β-Estradiol-metabolizing Isozymes: Comparison of Normal Human Mammary Gland to Normal Human Liver and to Cultured Human Breast Adenocarcinoma Cells......Page 606 Phytoestrogens Modulate the Expression of 17α-Estradiol Metabolizing Enzymes in Cultured MCF-7 Cells......Page 614 A......Page 622 B......Page 624 C......Page 626 D......Page 629 E......Page 630 F......Page 633 H......Page 634 I......Page 635 L......Page 636 M......Page 637 N......Page 638 O......Page 639 P......Page 640 R......Page 643 S......Page 644 T......Page 645 W......Page 646 Z......Page 647 Information gathered from cell-free systems, cell cultures, animal models, and human studies, together provide important insights to our understanding of hormonal cancer causation, development, and prevention; the primary objective of these Symposia. A special emphasis is placed on the two major endocrine-related cancers, that is, breast and prostate. The emerging fields of colon, lung, and pancreatic cancers in relation to hormones are examined.