Holland-Frei Cancer Medicine, 8/e (CANCER MEDICINE (HOLLAND))

The consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists and others who treat cancer patients, Cancer Medicine 8 covers the ever-widening sphere of current cancer knowledge and clinical practice. In this new 8th edition an outstanding editorial team from world-renowned medical centers continues to hone the leading edge forged in previous editions, with timely information on biology, immunology, etiology, epidemiology, prevention, screening, pathology, imaging and therapy. The book is a testament to the editorial panel’s creed that innovative, comprehensive, multidisciplinary treatment of cancer patients must be grounded in a fundamental understanding of cancer biology. Cancer Medicine 8 does a superb job of bringing scientific principles into clinical practice. This text is the ultimate resource of new information providing the basis for better informed cancer therapy choices. Cancer Medicine 8 features hundreds of 4-color illustrations, photographs, tables, graphs and algorithms that make this text an invaluable clinical tool in recognizing characteristic appearances of both patient and tissue. The 137 tightly focused chapters are organized into 5 sections: I: Cardinal Manifestations of Cancer II: Scientific Foundations of Cancer III: Principles of Cancer Diagnosis IV: Principles of Therapeutic Modalities V: Principles of Multidisciplinary Management Major Revisions: Chapter 6: Oncogenes An entire section is devoted to oncogenes like kit, Ret, Braf, Akt genes and the new drugs that specifically target them. This chapter not only provides a list of these new therapies but also insight as to how they target the oncogenes and their mutations, as well as therapy response and efficacy. Chapter 11: Tumor Angiogenesis This chapter provides a wealth of new data and understanding of the mechanisms of angiogenesis and how it contributes to the malignancy of various cancers The Clinical Advancement section provides an extensive summary of new trials investigating numerous novel angiogenesis agents Chapter 33: Chemoprevention This chapter also provides a considerable amount of new information for a broad range of clinical trials such as the HPV vaccine trial Future, Select, Star, Approve and PreSAP. The rationales for these trials are discussed and resulting data from the completed trials are presented. Chapter 55: Cytokines Research on cytokines is another area that is exploding in magnitude. This chapter presents a wealth of new information on promising new therapeutic agents.There is also updated information on the therapeutic usage of currently available agents such as hemotopoietic growth factors (HGF), erythropoietin and thromobopoietic agents. Chapter 56: Monoclonal Serotherapy A considerable amount of research has been done in the past few years on therapeutic and targeted agents in cancer therapy. Updated information and data is provided from recent trials for therapies previously discussed in Cancer Medicine edition 7 covering therapeutic agents and targeted toxins. Chapter 77: Neoplasms of the Head and Neck There is a discussion of changes in treatment methods for certain cancers such as the recent shift from surgery to combined chemotherapy with radiotherapy for tonsillar cancer, nasal and paranasal sinuses cancers and laryngeal cancer. Chapter 78: Lung Cancer Advances in diagnostic techniques are described such as ultrasound-guided fine needle aspiration or electromagnetic navigation diagnostic bronchoscopy. Video assisted thoracoscopic surgery (VATS) discussion is updated. New sections are devoted to prognostic and predictive biomarkers. Cover Holland-Frei Cancer Medicine 8 Frontmatter Contributors Contents 1: Cardinal Manifestations of Cancer 2: Molecular Biology, Genomics, Proteomics, and Mouse Models of Human Cancer 3: Cell Proliferation and Differentiation 4: Apoptosis and Cancer 5: Growth Factors and Signal Transduction in Cancer 6: Oncogenes 7: Tumor Suppressor Genes 8: Genomic Alterations and Chomosomal Aberrations in Human Cancer 9: Biochemistry of Cancer 10: Invasion and Metastases 11: Tumor Angiogenesis 12: Epigenetic Contributions to Human Cancer 13: Cancer Immunotherapy 14: Genetic Predisposition to Cancer 15: Chemical Carcinogenesis 16: Hormones and the Etiology of Cancer 17: Ionizing Radiation 18: Ultraviolet Radiation Carcinogenesis 19: Inflammation and Cancer 20: RNA Tumor Viruses 21: Herpesviruses 22: Papillomaviruses and Cerivcal Neoplasia 23: Hepatitis Viruses 24: Parasites 25: Molecular Imaging in Clinical Oncology 26: Molecular Diagnostics in Cancer 27: Personalized Medicine in Oncology Drug Development 28: Cancer Genome Aberrations: Measures, Causes, and Consequences 29: Cancer Nanotechnology 30: Cancer Epidemiology 31: Tobacco-Induced Cancers and Their Prevention 32: Nutrition in the Etiology and Prevention of Cancer 33: Chemoprevention of Cancer 34: Cancer Screening and Early Detection 35: Statistical Innovations in Cancer Research 36: Outcomes Research in Oncology 37: Principles of Cancer Pathology 38: Principles of Imaging 39: Interventional Radiology for the Cancer Patient 40: Principles of Surgical Oncology 41: Principles of Radiation Oncology 42: Hyperthermia 43: Principles of Medical Oncology 44: Cytokinetics 45: Princples of Dose, Schedule, and Combination Therapy 46: Preclinical and Early Clinical Development of New Anticancer Agents 47: Pharmacology 48: Drug Resistance and Its Clinical Circumvention 49: Folate Antagonists 50: Pyrimidine and Purine Antimetabolites 51: Alkylating Agents and Platinum Antitumor Compounds 52: Drugs that Target DNA Topoisomerases 53: Microtubule-Targeting Natural Products 54: Interferons 55: Cytokines and Hematopoietic Growth Factors 56: Monoclonal Serotherapy 57: Vaccines and Immunostimulants 58: Antiestrogens, Progestins, and Aromatase Inhibitors 59: Androgen Deprivation Strategies in the Treatment of Advanced Prostate Cancer 60: Cancer Gene Therapy 61: Hematopoietic Cell Transplantation 62: Principles of Psycho-Oncology 63: Principles of Cancer Rehabilitation Medicine 64: Multidisciplinary Management 65: Cancer and Pregnancy 66: Cancer and Aging 67: The Role of Integrative Oncology in Cancer Care 68: Palliative Care 69: Management of Cancer Pain 70: Primary Neoplasms of the Central Nervous System in Adults 71: Brain Metastases 72: Neoplasms of the Eye 73: Neoplasms of the Endocrine Glands: Pituitary Neoplasms 74: Neoplasms of the Thyroid 75: Neoplasms of the Adrenal Cortex 76: Tumors of the Diffuse Neuroendocrine and Gastroenteropancreatic Endocrine System 77: Neoplasms of the Head and Neck 78: Cancer of the Lung 79: Malignant Mesothelioma 80: Thymomas and Thymic Tumors 81: Tumors of the Heart and Great Vessels 82: Primary Germ Cell Tumors of the Thorax 83: Neoplasms of the Esophagus 84: Carcinoma of the Stomach 85: Treatment of Liver Metastases 86: Primary Neoplasms of the Liver 87: Gallbladder and Bile Duct Cancer 88: Neoplasms of the Exocrine Pancreas 89: Neoplasms of the Small Intestine, Vermiform Appendix, and Peritoneum, and Carcinoma of the Colon and Rectum 90: Neoplasms of the Anus 91: Renal Cell Carcinoma 92: Tumors of the Renal Pelvis and Ureter 93: Bladder Cancer 94: Neoplasms of the Prostate 95: Tumors of the Penis and Urethra 96: Testis Cancer 97: Neoplasms of the Vulva and Vagina 98: Neoplasms of the Cervix 99: Endometrial Cancer 100: Neoplasms of the Fallopian Tube 101: Ovarian Cancer 102: Molar Pregnancy and Gestational Trophoblastic Neoplasia 103: Gynecologic Sarcomas 104: Neoplasms of the Breast 105: Melanoma 106: Other Skin Cancers 107: Bone Tumors 108: Soft Tissue Sarcomas 109: The Myelodysplastic Syndrome 110: Acute Myeloid Leukemia in Adults: Mast Cell Leukemia and Other Mast Cell Neoplasms 111: Chronic Myeloid Leukemia 112: Acute Lymphoblastic Leukemia 113: Chronic Lymphocytic Leukemia 114: Hodgkin Lymphoma 115: Non-Hodgkin Lymphoma 116: Mycosis Fungoides and Sezary Syndrome 117: Plasma Cell Tumors 118: Myeloproliferative Neoplasms: Essential Thrombocythemia, Primary Myelofibrosis, and Polycythemia Vera 119: Neoplasms in Acquired Immunodeficiency Syndrome 120: Neoplasms of Unknown Primary Site 121: Principles of Pediatric Oncology 122: Anorexia and Cachexia 123: Antiemetic Therapy 124: Neurologic Complications 125: Dermatologic Complications of Cancer Chemotherapy 126: Skeletal Complications 127: Hematologic Complications and Blood Bank Support 128: Coagulopathic Complications of Cancer Patients 129: Urologic Complications 130: Cardiac Complications 131: Respiratory Complications 132: Gastrointestinal and Hepatic Complications in Cancer Patients 133: Oral Complications of Cancer and Their Treatment 134: Gonadal Complications 135: Endocrine Complications and Paraneoplastic Syndromes 136: Treatment-Related Secondary Cancers 137: Infections in Patients with Cancer 138: Oncologic Emergencies 139: Oncology Informatics Index Cardinal Manifestations Of Cancer -- Molecular Biology, Genomics, Proteomics, And Mouse Models Of Human Cancer -- Cell Proliferation And Differentiation -- Apoptosis And Cancer -- Growth Factors And Signal Transduction In Cancer -- Oncogenes -- Tumor Supressor Genes -- Genomic Alterations And Chromosomal Aberrations In Human Cancer -- Biochemistry Of Cancer -- Invasion And Metastases -- Tumor Angiogenesis -- Epigenetic Contributions To Human Cancer -- Cancer Immunotherapy -- Genetic Predisposition To Cancer -- Chemical Carcinogenesis -- Hormones And The Etiology Of Cancer -- Ionizing Radiation -- Ultraviolet Radiation Carcinogenesis -- Inflammation And Cancer -- Rna Tumor Viruses -- Herpesviruses -- Papillomaviruses And Cervical Neoplasia -- Hepatitis Viruses -- Parasites -- Molecular Imaging In Clinical Oncology -- Molecular Diagnostics In Cancer -- Personalized Medicine In Oncology Drug Development -- Cancer Genome Aberrations: Measures, Causes, And Consequences -- Cancer Nanotechnology -- Cancer Epidemiology -- Tobacco-induced Cancers And Their Prevention -- Nutrition In The Etiology And Prevention Of Cancer -- Chemoprevention Of Cancer -- Cancer Screening And Early Detection -- Statistical Innovations In Cancer Research -- Outcomes Research In Oncology -- Principles Of Cancer Pathology -- Principles Of Imaging -- Interventional Radiology For The Cancer Patient -- Principles Of Surgical Oncology -- Principles Of Radiation Oncology -- Hyperthermia -- Principles Of Medical Oncology -- Cytokinetics -- Principles Of Dose, Schedule, And Combination Chemotherapy -- Preclinical And Early Clinical Development Of New Anticancer Agents -- Pharmacology -- Drug Resistance And Its Clinical Circumvention. Folate Antagonists -- Pyrimidine And Purine Antimetabolites -- Alkylating Agents And Platinum Antitumor Compounds -- Drugs That Target Dna Topoisomerases -- Microtubule-targeting Natural Products -- Interferons -- Cytokines And Hematopoietic Growth Factors -- Monoclonal Serotherapy -- Vaccines And Immunostimulants -- Antiestrogens, Progentins, And Aromatase Inhibitors -- Androgen Deprivation Strategies In The Treatment Of Advanced Prostate Cancer -- Cancer Gene Therapy -- Hematopoietic Cell Transplantation -- Principles Of Psycho-oncology -- Principles Of Cancer Rehabilitation Medicine -- Multidisciplinary Management -- Cancer And Pregnancy -- Cancer And Aging -- The Role Of Integrative Oncology In Cancer Care -- Palliative Care -- Management Of Cancer Pain -- Primary Neoplasms Of The Central Nervous System In Adults -- Brain Metastases -- Neoplasms Of The Eye -- Neoplasms Of The Endocrine Glands: Pituitary Neoplasms -- Neoplasms Of The Thyroid -- Neoplasms Of The Adrenal Cortex -- Tumors Of The Diffuse Neuroendocrine And Gastroenteropancreatic Endocrine System -- Neoplasms Of The Head And Neck -- Cancer Of The Lung -- Malignant Mesothelioma -- Thymomas And Thymic Tumors -- Tumors Of The Heart And Great Vessels -- Primary Germ Cell Tumors Of The Thorax -- Neoplasms Of The Esophagus -- Carcinoma Of The Stomach -- Treatment Of Liver Metastases -- Primary Neoplasms Of The Liver. Gallbladder And Bile Duct Cancer -- Neoplasms Of The Exocrine Pancreas -- Neoplasms Of The Small Intestine, Vermiform Appendix, And Peritoneum, And Carcinoma Of The Colon And Rectum -- Neoplasms Of The Anus -- Renal Cell Carcinoma -- Tumors Of The Renal Pelvis And Ureter -- Bladder Cancer -- Neoplasms Of The Prostate -- Tumors Of The Penis And Urethra -- Testis Cancer -- Neoplasms Of The Vulva And Vagina -- Neoplasms Of The Cervix -- Endometrial Cancer -- Neoplasms Of The Fallapian Tube -- Ovarian Cancer -- Molar Pregnancy And Gestational Trophoblastic Neoplasia -- Gynecologic Sarcomas -- Neoplasms Of The Breast -- Melanoma -- Other Skin Cancers -- Bone Tumors -- Soft Tissue Sarcomas -- The Myelodysplastic Syndrome -- Acute Myeloid Leukemia In Adults: Mast Cell Leukemia And Other Mast Cell Neoplasms -- Chronic Myeloid Leukemia -- Acute Lymphoblastic Leukemia -- Chronic Lymphocytic Leukemia -- Hodgkin Lymphoma -- Non-hodgkin Lymphoma -- Mycosis Fungoides And Sézary Syndrome -- Plasma Cell Tumors -- Myeloproliferative Neoplasms: Essential Thrombocythemia, Primary Myelofibrosis, And Polycythemia Vera -- Neoplasms In Acquired Immunodeficiency Syndrome -- Neoplasms Of Unknown Primary Site -- Principles Of Pediatric Oncology -- Anorexia And Cachexia -- Antiemetic Therapy -- Neurologic Complications -- Dermatolgoic Complications Of Cancer Chemotherapy -- Skeletal Complications -- Hematologic Complications And Blood Bank Support -- Coagulopathic Complications Of Cancer Patients -- Urologic Complications -- Cardiac Complications -- Respiratory Complications -- Gastrointestinal And Hepatic Complications In Cancer Patients -- Oral Complications Of Cancer And Their Treatment -- Gonadal Complications -- Endocrine Complications And Paraneoplastic Syndromes -- Treatment-related Secondary Cancers -- Infections In Patients With Cancer -- Oncologic Emergencies -- Oncology Informatics. Rev. Ed. Of: Holland Frei Cancer Medicine 7 / Editors, Donald W. Kufe ... [et Al.]. 7th Ed. 2006. Includes Bibliographical References And Index. "The consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients, Cancer Medicine 8 covers the ever-widening sphere of current cancer knowledge and clinical practice. In this new 8th edition an outstanding editorial team from world-renowned medical centers continues to hone the leading edge forged in previous editions, with timely information on biology, immunology, etiology, epidemiology, prevention, screening, pathology, imaging, and therapy. The book is a testament to the editorial panel s creed--that innovative, comprehensive, multidisciplinary treatment of cancer patients must be grounded in a fundamental understanding of cancer biology. Cancer Medicine 8 does a superb job of bringing scientific principles into clinical practice. This text is the ultimate resource of new information providing the basis for better informed cancer therapy choices. Cancer Medicine 8 features hundreds of 4-color illustrations, photographs, tables, graphs and algorithms that make this text an invaluable clinical tool in recognizing characteristic appearances of both patient and tissue. The 137 tightly focused chapters are organized into 5 sections : Cardinal manifestations of cancer; scientific foundations of cancer; principles of cancer diagnosis; principles of therapeutic modalities; principles of multidisciplinary management