Hoffbrand's Essential Haematology (Essentials), 9e (June 25, 2024)_(1394168152)_(Wiley-Blackwell).pdf

The latest edition of the best-selling haematology textbook for undergraduate and postgraduate students and trainees Now in its ninth edition, Hoffbrand's Essential Haematology remains the definitive introductory textbook in the field. A team of leading experts provide clear and authoritative coverage of fundamental areas of clinical and laboratory haematology, including basic science, clinical features, diagnostic procedures and patient management. The text includes hundreds of high-quality colour images illustrating different anaemias, white cell and platelet disorders, leukaemias, myeloproliferative diseases, lymphomas, myeloma, bleeding and thrombotic disorders. Thoroughly revised and updated, Hoffbrand's Essential Haematology reflects current knowledge of the pathogenesis of blood diseases, their classification, diagnosis and treatment algorithms incorporating novel agents. The role of detection of minimal residual disease in management, and recent advances in immunological treatment of benign and malignant blood disorders, including CAR-T cell therapy, are highlighted. This edition contains expanded coverage of clonal haemopoiesis, the non-Hodgkin lymphomas amyloidosis, hospital related thrombosis, new treatments for haemophilia, and the use of direct-acting oral anticoagulants. Gene therapy for sickle cell anaemia, thalassaemia, and haemophilia feature and a new section focuses on the haematological consequences of COVID-19 infection and vaccine-induced immune thrombotic thrombocytopenia (VITT). Helping medical students and trainee doctors understand the core principles of clinical and laboratory haematology for more than 40 years, Hoffbrand's Essential Haematology: Describes the formation and function of blood cells and the diseases that arise from the bone marrow, lymph nodes and blood Provides comprehensive and up-to-date coverage of molecular and immunological basis, diagnosis, and management of blood diseases Covers a wide range of key topics, including stem cell transplantation, blood transfusion, the haematological aspects of systemic diseases, of pregnancy and of the neonate Incorporates the current 5th World Health Organisation (WHO) classification of haematological neoplastic diseases Includes access to a companion website with hundreds of multiple-choice questions, PowerPoint slides, and other teaching and learning resources Hoffbrand's Essential Haematology, Ninth Edition, is a must-have resource for undergraduate medical students, biomedical science undergraduates and postgraduates, and trainees in haematology. Cover Title Page Copyright Page Contents Preface to the Ninth Edition About the Companion Website Chapter 1 Haemopoiesis Site of haemopoiesis Haemopoietic stem and progenitor cells Bone marrow stroma and niches The regulation of haemopoiesis Transcription factors Haemopoietic growth factors Growth factor receptors and signal transduction Adhesion molecules The cell cycle Epigenetics Apoptosis Chapter 2 Erythropoiesis and general aspects of anaemia Blood cells Erythropoiesis Erythropoietin Indications for erythropoietin therapy Haemoglobin Haemoglobin synthesis Haemoglobin function Methaemoglobinaemia The red cell Red cell metabolism Embden–Meyerhof pathway Hexose monophosphate (pentose phosphate) shunt Red cell membrane Anaemia Global incidence Clinical features of anaemia Symptoms Signs Classification of anaemia Red cell indices Other laboratory findings Bone marrow examination Ineffective erythropoiesis Assessment of erythropoiesis Chapter 3 Hypochromic anaemia