Hodgkin's and Non-Hodgkin's Lymphoma (Cancer Treatment and Research Book 131)

Over recent years, there has been a dramatic increase in knowledge of the biology of the lymphomas which has been accompanied by the emergence of new treatments that offer both improvements in efficacy and reduction in toxicity. Molecular profiling of tumor tissue and other new advances have led to a better understanding of the genetic basis of lymphoma, identification of new therapeutic targets, and potentially valuable prognostic information. Monoclonal antibody therapies, radioimmunoconjugates and other new agents such as proteosome inhibitors are providing important new treatment options for patients. In this volume, an internationally recognized group of experts provides a comprehensive overview of the biology, pathology, standard treatments, and novel approaches in management of patients across the complex landscape of lymphoma subtypes. Researchers and practitioners alike will welcome this useful summary of the state of the art in this field.

Over recent years, there has been a dramatic increase in knowledge of the biology of the lymphomas which has been accompanied by the emergence of new treatments that offer both improvements in efficacy and reduction in toxicity. Molecular profiling of tumor tissue and other new advances have led to a better understanding of the genetic basis of lymphoma, identification of new therapeutic targets, and potentially valuable prognostic information. Monoclonal antibody therapies, radioimmunoconjugates and other new agents such as proteosome inhibitors are providing important new treatment options for patients.

In this volume, an internationally recognized group of experts provides a comprehensive overview of the biology, pathology, standard treatments, and novel approaches in management of patients across the complex landscape of lymphoma subtypes. Researchers and practitioners alike will welcome this useful summary of the state of the art in this field.

Front Matter....Pages i-xi Pathology of B-Cell Non-Hodgkin’s Lymphomas and Multiple Myeloma....Pages 1-48 Pathogenesis of Viral Lymphomas....Pages 49-88 The Indolent B-Cell Lymphomas....Pages 89-120 Diffuse Large B-Cell NHL....Pages 121-140 Mantle Cell Lymphoma: Current Concept in Biology and Treatment....Pages 141-159 T-Cell Non-Hogdkin’s Lymphoma....Pages 161-220 Monoclonal Antibodies in the Treatment of Non-Hodgkin’s Lymphoma....Pages 221-250 Blood and Bone Marrow Transplantation for Patients with Hodgkin’s and Non-Hodgkin’s Lymphoma....Pages 251-281 Vaccine Therapies for Non-Hodgkin’s Lymphomas....Pages 283-315 Management of Early Stage Hodgkin’s Lymphoma....Pages 317-332 Management of Advanced Stage Hodgkin’s Lymphoma....Pages 333-352 Nodular Lymphocyte Predominant Hodgkin’s Disease....Pages 353-362 Lymphoma Imaging: Nuclear Medicine....Pages 363-412 Novel Small Molecules in the Treatment of Lymphomas....Pages 413-460 Back Matter....Pages 461-471 In recent years a dramatic increase in knowledge of the biology of the lymphomas has been accompanied by the emergence of new treatments offering improvements in efficacy and reduction in toxicity. In this volume an internationally recognized group of experts review relevant aspects of the biology, diagnosis and management, with particular emphasis on the emerging data available for this disease.