HIV & HTLV-I Associated Malignancies (Cancer Treatment and Research, 104)

Infection with the human immunodeficiency virus (HIV) and human T-cell lymphotropic virus type I (HTLV-I) is known to be associated with an increased risk of neoplastic disorders, especially Kaposi's sarcoma and aggressive B-cell lymphoma for the former, and T-cell lymphoma for the latter. The information obtained from the study of these infections has led to remarkable advances in our understanding of the immune system, as well as the biology of human neoplasms. The management of malignant diseases in such patients also poses substantial challenges to clinicians. This book provides an overview of the epidemiology, biology, clinical features, and clinical management of neoplasms occurring in such individuals. It is an important resource for clinicians treating these diseases, and for basic scientists who have an interest in this field. Front Matter....Pages i-xii Epidemiology of HIV-Associated Malignancies....Pages 1-18 Immunopathogenesis of HIV and HTLV-1 Infection: Mechanisms for Lymphomagenesis....Pages 19-74 HTLV-I Associated Leukemia/Lymphoma: Epidemiology, Biology, and Treatment....Pages 75-88 The Biology of Kaposi’s Sarcoma....Pages 89-126 Treatment of Kaposis Sarcoma....Pages 127-148 Biology of Non-Hodgkin’s Lymphoma....Pages 149-200 Non-Hodgkin’s Lymphoma: Pathogenesis, Clinical Presentation, and Treatment....Pages 201-230 Primary Central Nervous System Lymphoma....Pages 231-246 Hodgkin’s Disease: Clinical Presentation and Treatment....Pages 247-265 Biology of Anogenital Neoplasia....Pages 267-286 Management of Cervical Neoplasia....Pages 287-302 Non-AIDS-Defining Malignancies....Pages 303-328 Hematopoiesis in HIV Infection: Use of Colony Stimulating Factors and Cytokines....Pages 329-346 Special Considerations Regarding Antiretroviral Therapy and Infection Prophylaxis in the HIV-Infected Individual with Cancer....Pages 347-366 AIDS Malignancy Clinical Research: Resources of the National Cancer Institute....Pages 367-372 Back Matter....Pages 373-378