Histone Deacetylases: Transcriptional Regulation and Other Cellular Functions (Cancer Drug Discovery and Development)

The recent discoveries that established histone acetylation as a key regulatory mechanism for gene expression triggered a wave of interest in histone posttranslational modifications and led to the development of novel anticancer agents now in clinical trials. In Histone Deacetylases: Transcriptional Regulation and Other Cellular Functions, a panel of leading investigators summarizes and synthesizes the new discoveries in this rapidly evolving field. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes-both alone and in complex with small-molecule inhibitors-and the biological roles of the several histone deacetylase (HDAC) genes that have been knocked out in mice. Authoritative and state-of-the-art, Histone Deacetylases: Transcriptional Regulation and Other Cellular Functions constitutes a first landmark of what has been accomplished so far and sets a clear agenda for the full definition of HDAC roles in biology and disease in the years to come. Histone deacetylase / Dominique Meunier and Christian Seiser Biochemistry of multiprotein HDAC complexes / Alejandro Vaquero, Michael Scher, and Danny Reinberg The biology of HDAC3 / Edward Seto The biology of HDAC8, a unique class I histone deacetylase / David Waltregny and Vincent Castronovo Regulation of muscle gene expression by histone deacetylases / Timothy A. McKinsey and Eric N. Olson The class IIA histone deacetylases: functions and regulation / Herbert G. Kasler and Eric Verdin Histone deacetylases in the response to misfolded proteins / J. Andrew McKee and Tso-Pang Yao Comparison of sirtuin sequences between archaea and vertebrates / Roy A. Frye Structure of the Sir2 family of NAD+-dependent histone/protein deacetylases / Kehao Zhao and Ronen Marmorstein The enzymology of Sir2 proteins / Margie T. Borra and John M. Denu The class III protein deacetylases: homologs of yeast Sir2P / Bjoern Schwer ... [et al.] HDAC inhibitors: discovery, development, and clinical impacts / Akihiro Ito, Norikazu Nishino, and Mitsuaki Yoshida Cell cycle targets of histone deacetylase inhibitors / Brian Gabrielli HDAC inhibitors: an emerging anticancer therapeutic strategy / Paul Kwon, Meier Hsu, Dalia Cohen, and Peter Atadja. Front Matter....Pages i-xi Front Matter....Pages 1-1 Histone Deacetylase 1....Pages 3-22 Biochemistry of Multiprotein HDAC Complexes....Pages 23-60 The Biology of HDAC3....Pages 61-86 The Biology of HDAC8, a Unique Class I Histone Deacetylase....Pages 87-104 Front Matter....Pages 105-105 Regulation of Muscle Gene Expression by Histone Deacetylases....Pages 107-128 The Class IIa Histone Deacetylases....Pages 129-163 Histone Deacetylases in the Response to Misfolded Proteins....Pages 165-180 Front Matter....Pages 181-181 Evolution of Sirtuins From Archaea to Vertebrates....Pages 183-202 Structure of the Sir2 Family of NAD + -Dependent Histone/Protein Deacetylases....Pages 203-217 The Enzymology of SIR2 Proteins....Pages 219-235 The Class III Protein Deacetylases....Pages 237-268 Front Matter....Pages 269-269 HDAC Inhibitors....Pages 271-297 Cell Cycle Targets of Histone Deacetylase Inhibitors....Pages 299-313 HDAC Inhibitors....Pages 315-332 Back Matter....Pages 333-340 "In Histone Deacetylases: Transcriptional Regulation and Other Cellular Functions, a panel of investigators summarizes and synthesizes the new discoveries in this rapidly evolving field. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes - both alone and in complex with small-molecule inhibitors - and the biological roles of the several histone deacetylase (HDAC) genes that have been knocked out in mice. This book constitutes a first landmark of what had been accomplished so far and sets a clear agenda for the full definition of HDAC roles in biology and disease in the years to come." --Résumé de l'éditeur "In Histone Deacetylases: Transcriptional Regulation and Other Cellular Functions, a panel of investigators summarizes and synthesizes the new discoveries in this rapidly evolving field. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes - both alone and in complex with small-molecule inhibitors - and the biological roles of the several histone deacetylase (HDAC) genes that have been knocked out in mice. This book constitutes a first landmark of what had been accomplished so far and sets a clear agenda for the full definition of HDAC roles in biology and disease in the years to come."--BOOK JACKET A panel of leading investigators summarizes and synthesizes the new discoveries in the rapidly evolving field of histone acetylation as a key regulatory mechanism for gene expression. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes-both alone and in complex with small molecule inhibitors-and the biological roles of the several histone deacetylases (HDAC) genes that have been knocked out in mice. A panel of leading investigators summarizes and synthesizes the new discoveries in the rapidly evolving field of histone acetylation as a key regulatory mechanism for gene expression. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes - both alone and in complex with small molecule inhibitors - and the biological roles of the several histone d