Histone Deacetylases: the Biology and Clinical Implication (Handbook of Experimental Pharmacology, Vol. 206) (Handbook of Experimental Pharmacology, 206)

The book highlights work from many different labs that taught us abnormal HDACs potentially contribute to the development or progression of many human diseases including immune dysfunctions, heart disease, cancer, memory impairment, aging, and metabolic disorders. K-acetylation and its enzymes: overview and new developments / Juliette Adjo Aka, Go-Woon Kim, Xiang-Jiao Yang. Biology of HDAC in cancer: the nuclear and epigenetic components / Astrid Hagelkruys, Anna Sawicka, Magdalena Rennmayer, Christian Seiser. Deacetylation of nonhistone proteins by HDACs and the implications in cancer / Lirong Peng, Edward Seto. Biology and therapeutic implications of HDACs in the heart / Timothy A. McKinsey. HDACs in skeletal muscle remodeling and neuromuscular disease / Bryan J. Simmons, Todd J. Cohen, Richard Bedlack, Tso-Pang Yao. Rationale for HDAC inhibitor therapy in autoimmunity and trasplantation / Wayne W. Hancock. Role of mammalian sirtuins in the regulation of metabolism, aging, and longevity / Akiko Satoh, Liana Stein, Shin Imai. Mictochondrial sirtuins in the regulation of mictochondrial activity and metabolic adaption / David B. Lombard, Daniel X. Tishkoff, Jianjun Bao. Characterization of nuclear sirtuins: molecular mechanisms and physiological relevance / Debra Toiber, Carlos Sebastian, Raul Mostoslavsky. Structural biology of human netal-dependent histone deacetylases / Matthieu Schapira. Sirtuin modulators / Sumit S. Mahajan, Vid Leko, Julian A. Simon, Antonio Bedalov. Front Matter....Pages i-xi K-Acetylation and Its Enzymes: Overview and New Developments....Pages 1-12 The Biology of HDAC in Cancer: The Nuclear and Epigenetic Components....Pages 13-37 Deacetylation of Nonhistone Proteins by HDACs and the Implications in Cancer....Pages 39-56 The Biology and Therapeutic Implications of HDACs in the Heart....Pages 57-78 HDACs in Skeletal Muscle Remodeling and Neuromuscular Disease....Pages 79-101 Rationale for HDAC Inhibitor Therapy in Autoimmunity and Transplantation....Pages 103-123 The Role of Mammalian Sirtuins in the Regulation of Metabolism, Aging, and Longevity....Pages 125-162 Mitochondrial Sirtuins in the Regulation of Mitochondrial Activity and Metabolic Adaptation....Pages 163-188 Characterization of Nuclear Sirtuins: Molecular Mechanisms and Physiological Relevance....Pages 189-224 Structural Biology of Human Metal-Dependent Histone Deacetylases....Pages 225-240 Sirtuin Modulators....Pages 241-255 Back Matter....Pages 257-260