Histamine Receptors: Preclinical and Clinical Aspects (The Receptors, 28)

A comprehensive and detailed overview of the current state of preclinical research on histamine and histamine receptors. Part of the book focuses on novel approaches to the study of histamine receptors such as polymorphism, genetic linkage, and computational analysis, and on the use of new histaminergic ligands in diseases such as asthma and dermatitis. Several chapters will be devoted to the role of histamine in the control of homeostatic and behavioral responses such as the sleep-wake cycle, regulation of the blood brain barrier, food intake, alertness, itch, and memory formation and consolidation. Front Matter....Pages i-xiv Molecular Aspects of Histamine Receptors....Pages 1-49 Genetic Polymorphisms in the Histamine Receptor Family....Pages 51-74 The Role of Histamine H4 Receptor in Asthma and Atopic Dermatitis....Pages 75-92 Identification and Roles of Zebrafish Histamine Receptors....Pages 93-107 Histamine H3R Antagonists: From Scaffold Hopping to Clinical Candidates....Pages 109-155 Clinical Significance of Histamine H1 Receptor Gene Expression and Drug Action of Antihistamines....Pages 157-172 Histamine and Its Receptors as a Module of the Biogenic Amine Diseasome....Pages 173-214 Histaminergic Regulation of Blood–Brain Barrier Activity....Pages 215-230 Histamine Function in Nervous Systems....Pages 231-249 Heterogeneity of Histaminergic Neurons....Pages 251-263 Modulation by Histamine H3 Receptors of Neurotransmitter Release in the Basal Ganglia....Pages 265-293 Interaction of Brain Histaminergic and Dopaminergic Systems....Pages 295-310 Histamine H1 Receptor Occupancy in the Human Brain Measured by Positron Emission Tomography....Pages 311-325 Modulation of Memory Consolidation, Retrieval and Extinction by Brain Histamine....Pages 327-340 Histamine and Appetite....Pages 341-360 Back Matter....Pages 361-373