Histamine in Inflammation (Advances in Experimental Medicine and Biology, 709)

The year 2010 marks the centennial for the identification of histamine and the first glimpse of its many physiological functions. From these initial findings a rich tapestry of research has uncovered roles for histamine in almost every physiological process with new findings emerging every year. These diverse roles of histamine have made for fertile ground for the discovery of novel therapeutics, and these drugs have been so successful that the term “antihistamine” has entered the common lexicon. This volume is an attempt to give a snapshot in time as to the current understanding of the role of histamine in just one important therapeutic area—inflammation. The first three chapters provide some background context for the rest of the book starting out with a historical perspective by Figueroa and Shankley. Bongers et al provide an overview of the pharmacology of the four histamine receptors and the chapter by Hiroshi Ohtsu describes how histamine is synthesized as well as the insights derived from mice where this synthesis is disrupted. The next several chapters discuss disease areas where histamine is known to be involved. Chapter 4 by Thomas Taylor-Clark outlines the role of histamine in allergic rhinitis, an area were antihistamines are commonly used. This is also true for ocular allergy as discussed by Ohbayashi et al. Both of these chapters highlight aspects of these conditions that are still not well-controlled and suggest the utility of new antihistamines targeting other histamine receptors. One Hundred Years Of Histamine Research / Katherine Figueroa And Nigel Shankley -- Molecular Pharmacology Of The Four Histamine Receptors / Gerold Bongers, Iwan De Esch, And Rob Leurs -- Histamine Synthesis And Lessons Learned From Histidine Decarboxylase Deficient Mice / Hiroshi Ohtsu -- Histamine In Allergic Rhinitis / Thomas Taylor-clark -- The Role Of Histamine In Ocular Allergy / Masaharu Ohbayashi ... [et Al.] -- The Role Of Histamine In Asthma / Paul J. Dunford And Stephen T. Holgate -- Antihistamines In The Treatment Of Urticaria / Torsten Zuberbier And Marcus Maurer -- Histamine And Antihistamines In Atopic Dermatitis / Jørg Buddenkotte, Marcus Maurer, And Martin Steinhoff -- Histamine, Immune Cells, And Autoimmunity / Elke Schneider, Maria Leite-de-moraes, And Michel Dy -- Histamine In Neurotransmission And Brain Diseases / Saara Nuutinen And Pertti Panula -- Histamine In Normal And Malignant Cell Proliferation / Andras Falus, Zoltøn Pøs, And Zsuzsanna Darvas -- The Future Antihistamines : Histamine H3 And H4 Receptor Ligands / Fuqu Yu, Pascal Bonaventure, And Robin L. Thurmond. Edited By Robin L. Thurmond. Includes Bibliographical References And Index. One hundred years of histamine research / Katherine Figueroa and Nigel Shankley Molecular pharmacology of the four histamine receptors / Gerold Bongers, Iwan de Esch, and Rob Leurs Histamine synthesis and lessons learned from histidine decarboxylase deficient mice / Hiroshi Ohtsu Abstract Histamine in allergic rhinitis / Thomas Taylor-Clark The role of histamine in ocular allergy / Masaharu Ohbayashi ... [et al.] The role of histamine in asthma / Paul J. Dunford and Stephen T. Holgate Antihistamines in the treatment of urticaria / Torsten Zuberbier and Marcus Maurer Histamine and antihistamines in atopic dermatitis / Jørg Buddenkotte, Marcus Maurer, and Martin Steinhoff Histamine, immune cells, and autoimmunity / Elke Schneider, Maria Leite-de-Moraes, and Michel Dy Histamine in neurotransmission and brain diseases / Saara Nuutinen and Pertti Panula Histamine in normal and malignant cell proliferation / Andras Falus, Zoltøn Pøs, and Zsuzsanna Darvas The future antihistamines : histamine H3 and H4 receptor ligands / Fuqu Yu, Pascal Bonaventure, and Robin L. Thurmond. Front Matter....Pages i-xviii One Hundred Years of Histamine Research....Pages 1-9 Molecular Pharmacology of the Four Histamine Receptors....Pages 11-19 Histamine Synthesis and Lessons Learned from Histidine Decarboxylase Deficient Mice....Pages 21-31 Histamine in Allergic Rhinitis....Pages 33-41 The Role of Histamine in Ocular Allergy....Pages 43-52 The Role of Histamine in Asthma....Pages 53-66 Antihistamines in the Treatment of Urticaria....Pages 67-72 Histamine and Antihistamines in Atopic Dermatitis....Pages 73-80 Histamine, Immune Cells and Autoimmunity....Pages 81-94 Histamine in Neurotransmission and Brain Diseases....Pages 95-107 Histamine in Normal and Malignant Cell Proliferation....Pages 109-123 The Future Antihistamines: Histamine H 3 and H 4 Receptor Ligands....Pages 125-140 Back Matter....Pages 141-143 The year 2010 marks the centennial for the identification of histamine and the first glimpse of its many physiological functions. From these initial findings a rich tapestry of research has uncovered roles for histamine in almost every physiological process with new findings emerging every year. These diverse roles of histamine have made for fertile ground for the discovery of novel therapeutics, and these drugs have been so successful that the term "antihistamine" has entered the common lexicon. This book is an attempt to give a snapshot in time as to the current understanding of th