Histamine Ii And Anti-histaminics: Chemistry, Metabolism And Physiological And Pharmacological Actions (handbook Of Experimental Pharmacology)

In the preface to Part I of this volume, which appeared in 1966, we stated: " ... we had to leave the Antihistaminics for another volume of unpredictable dimensions. In 1924, eight pages inserted in a Chapter on Mutterkorn by Arthur R.Cushing were considered enough, in Vol. II, Part II, pp. 1319-1326 of the Hand­ buch. Now 922 pages did not suffice to cover all aspects of the subject ... the subject has been expanded in so many directions, that the anti histaminic part had to be excluded from the present volume. Possibly, another thousand pages will be necessary to cover what remains of the subject."\* This prediction was fulfilled, and the subject of histamine has grown to such an extent that dealing with the antihistaminics only in Part II would be quite inadequate. It is imperative to include the large number of recent findings on the subject of histamine, namely the splitting of its pharmacologic receptors, and the great variety of new contributions on ,its participation in physiopathologic phenomena, metabolism and interaction with newly found mediators. In the preface to Part I of this volume, which appeared in 1966, we stated: " ... we had to leave the Antihistaminics for another volume of unpredictable dimensions. In 1924, eight pages inserted in a Chapter on Mutterkorn by Arthur R. Cushing were considered enough, in Vol. II, Part II, pp. 1319-1326 of the HandƯ buch. Now 922 pages did not suffice to cover all aspects of the subject ... the subject has been expanded in so many directions, that the anti histaminic part had to be excluded from the present volume. Possibly, another thousand pages will be necessary to cover what remains of the subject."* This prediction was fulfilled, and the subject of histamine has grown to such an extent that dealing with the antihistaminics only in Part II would be quite inadequate. It is imperative to include the large number of recent findings on the subject of histamine, namely the splitting of its pharmacologic receptors, and the great variety of new contributions on, its participation in physiopathologic phenomena, metabolism and interaction with newly found mediators Front Matter....Pages II-XIX Pharmacological Actions....Pages 1-56 Histamine Release....Pages 57-108 Metabolism and Excretion of Histamine....Pages 109-173 Chemistry of Anti-H 1 Histamine Antagonists....Pages 175-214 Structure-Activity Relationships of H 1 -Receptor Antagonists....Pages 215-249 Chemistry and Structure-Activity Relationships of H 2 -Receptor Antagonists....Pages 251-294 Kinetics of Antagonist Action....Pages 295-332 Competitive and Noncompetitive Antagonism....Pages 333-367 Naturally Occurring Antihistaminics in Body Tissues....Pages 369-380 Bioassay of Antihistaminic Action....Pages 381-437 Antianaphylactic and Antiallergic Effects....Pages 439-504 Antiinflammatory Effects....Pages 505-512 Absorption, Distribution, Metabolism, and Elimination of Antihistamines....Pages 513-560 Antihistaminics as Central Nervous System Depressants....Pages 561-573 Circulatory Shock, Histamine, and Antihistamines: Therapeutic Aspects....Pages 575-602 Back Matter....Pages 603-702