Histamine and Anti-Histaminics: Part 1: Histamine. Its Chemistry, Metabolism and Physiological and Pharmacological Actions (Handbook of Experimental Pharmacology, 18 / 1)

It was an agreable, though strenuous task to edit a book with so many distin­ guished contributors, on a subject to which I have given half of my life. In 1959, when Prof. O. EICHLER invited me to edit a book on "Histamine and Anti­ histaminics", as a supplement to HEFFTER'S Handbuch, I thought the task could be done in three years. Now, five years are gone and only half is fulfilled. Though, so far as the "Histamine" part of the book is concerned, the initial plan has been followed very closely, we had to leave the Anti-histaminics for another volume of unpredictable dimensions. In 1924, eight pages inserted in a Chapter on M utterkorn, by ARTHUR R. CUSHING were considered enough, in vol. II, Part II, pg. 1319-1326, of the Handbuch. Now, 922 pages did not suffice to cover all the aspects of the subject. Especially in the last few years the subject has expanded in so many directions, that the antihistaminic part had to be excluded from the present volume. Possibly, another thousand pages will be necessary to cover what remains of the subject. In planning the book we made great use of the excellent and classical mono­ graph by W. FELDBERG and E. SCHILF on Histamin, published by Julius Springer, in 1930. Front Matter....Pages II-XXXV Chemistry of Histamine and Analogs. Relationship between Structure and Pharmacological Activity....Pages 1-43 Die Isolierung von Histamin aus biologischem Material....Pages 44-56 Determination of Histamine by Chemical Means....Pages 57-80 Biological Determination of Histamine in Living Tissues and Body Fluids....Pages 81-115 The Occurrence of Histamine in Mast Cells....Pages 116-135 Histochimie des mastocytes....Pages 136-147 Absorption de l’histamine par l’appareil digestif....Pages 148-161 Captation de l’histamine par les protéines sériques....Pages 162-178 Toxicity of Histamine: Lethal Doses....Pages 179-201 Action de l’histamine sur les muscles lisses....Pages 202-224 Action of Histamine on the Smooth Muscle....Pages 225-237 Action of Histamine upon the Circulatory Apparatus....Pages 238-293 Action of Histamine upon Salivary Glands....Pages 294-301 Effect of Histamine on Gastric Secretion....Pages 302-317 Relationship Between Histamine and the Autonomous Nervous System....Pages 318-333 Release of Histamine by Animal Venoms and Bacterial Toxins....Pages 334-366 Release of Histamine by Noxious Physical Agents, Organic Compounds and by Metals....Pages 367-385 Histamine Release by Basic Compounds....Pages 386-430 Release of Histamine in Anaphylaxis....Pages 431-480 Makromolekulare Histaminliberatoren....Pages 481-568 Release of Histamine from Mast Cells....Pages 569-636 Interaction of Mast Cells with Cationic Histamine Releasers....Pages 637-644 Release of Histamine in Relation to Phosphorylation and Respiration....Pages 645-659 L’excrétion de l’histamine....Pages 660-671 Catabolism of Histamine in vivo ....Pages 672-683 In Vitro Metabolism of Histamine (Exclusive of Diamine Oxidase)....Pages 684-687 Enzymatic Formation of Histamine from Histidine....Pages 688-725 Histamine — Pyridine Coenzyme Interactions....Pages 726-733 Histamine Metabolism in Man....Pages 734-788 Histamine in the Brain....Pages 789-796 Rôle de l’histamine dans la vasodilatation d’origine postéro-radiculaire....Pages 797-809 Physiological Significance of the Effect of Histamine on Gastric Secretion....Pages 810-891 The Relation of Histamine to Inflammation....Pages 892-898 L’histamine dans l’allergie humaine....Pages 899-917 Histamine and Experimental Asthma of the Guinea Pig....Pages 918-922 Back Matter....Pages 923-991