High Density Lipoproteins: From Biological Understanding to Clinical Exploitation (Handbook of Experimental Pharmacology (224))

In this Handbook of Experimental Pharmacology on "High Density Lipoproteins – from biological understanding to clinical exploitation" contributing authors (members of COST Action BM0904/HDLnet) summarize in more than 20 chapters our current knowledge on the structure, function, metabolism and regulation of HDL in health and several diseases as well as the status of past and ongoing attempts of therapeutic exploitation. The book is of interest to researchers in academia and industry focusing on lipoprotein metabolism, cardiovascular diseases and immunology as well as clinical pharmacologists, cardiologists, diabetologists, nephrologists and other clinicians interested in metabolic or inflammatory diseases. Front Matter....Pages i-xiii Front Matter....Pages 1-1 Structure of HDL: Particle Subclasses and Molecular Components....Pages 3-51 HDL Biogenesis, Remodeling, and Catabolism....Pages 53-111 Regulation of HDL Genes: Transcriptional, Posttranscriptional, and Posttranslational....Pages 113-179 Cholesterol Efflux and Reverse Cholesterol Transport....Pages 181-206 Functionality of HDL: Antioxidation and Detoxifying Effects....Pages 207-228 Signal Transduction by HDL: Agonists, Receptors, and Signaling Cascades....Pages 229-256 Front Matter....Pages 257-257 Epidemiology: Disease Associations and Modulators of HDL-Related Biomarkers....Pages 259-283 Beyond the Genetics of HDL: Why Is HDL Cholesterol Inversely Related to Cardiovascular Disease?....Pages 285-300 Mouse Models of Disturbed HDL Metabolism....Pages 301-336 Dysfunctional HDL: From Structure-Function-Relationships to Biomarkers....Pages 337-366 Front Matter....Pages 367-367 HDL and Atherothrombotic Vascular Disease....Pages 369-403 HDLs, Diabetes, and Metabolic Syndrome....Pages 405-421 High-Density Lipoprotein: Structural and Functional Changes Under Uremic Conditions and the Therapeutic Consequences....Pages 423-453 Impact of Systemic Inflammation and Autoimmune Diseases on apoA-I and HDL Plasma Levels and Functions....Pages 455-482 HDL in Infectious Diseases and Sepsis....Pages 483-508 High-Density Lipoproteins in Stroke....Pages 509-526 Therapeutic Potential of HDL in Cardioprotection and Tissue Repair....Pages 527-565 Front Matter....Pages 567-567 HDL and Lifestyle Interventions....Pages 569-592 Effects of Established Hypolipidemic Drugs on HDL Concentration, Subclass Distribution, and Function....Pages 593-615 Emerging Small Molecule Drugs....Pages 617-630 Front Matter....Pages 567-567 ApoA-I Mimetics....Pages 631-648 Antisense Oligonucleotides, microRNAs, and Antibodies....Pages 649-689 Back Matter....Pages 691-694 Seit Jahren wird unser Alltag geprägt von zunehmender Automation und Vernetzung, die Digitalisierung genannt wird. Sensoren erfassen immer mehr unterschiedliche Daten und werden von intelligenten Algorithmen zunehmend präzisier analysiert. Dies führt nicht nur zu einem anderen Verhältnis im Umgang und bei der Nutzung von Daten durch Menschen und Maschinen, sondern wird auch dramatisch Aufgaben und Prozesse verändern. Die damit verbundenen Arbeitsanforderungen werden zum massiven Wandel von Berufsbildern führen, in dem einfache Tätigkeiten automatisiert und komplexe Tätigkeiten vereinfacht werden. Nicht nur das Arbeiten sondern auch das Lernen, Lehren und Forschen verändert sich durch die Digitalisierung. Die technischen Möglichkeiten wandeln die Lebenswelten mit ihren urbanen Versorgungs- und Infrastrukturen und eröffnen den Wirtschaftsräumen neue Geschäftsmodelle. Diese parallel einsetzenden Entwicklungen führen zu radikalen Umbrüchen, die in den kommenden Jahren sämtliche Aspekte der Gesellschaft verändern werden In this Handbook of Experimental Pharmacology on __“High Density Lipoproteins – from biological understanding to clinical exploitation”__contributing authors (members of COST Action BM0904/HDLnet) summarize in more than 20 chapters our current knowledge on the structure, function, metabolism and regulation of HDL in health and several diseases as well as the status of past and ongoing attempts of therapeutic exploitation. The book is of interest to researchers in academia and industry focusing on lipoprotein metabolism, cardiovascular diseases and immunology as well as clinical pharmacologists, cardiologists, diabetologists, nephrologists and other clinicians interested in metabolic or inflammatory diseases. "In this Handbook of Experimental Pharmacology on "High Density Lipoproteins: from biological understanding to clinical exploitation" contributing authors (members of COST Action BM0904/HDLnet) summarize in more than 20 chapters our current knowledge on the structure, function, metabolism and regulation of HDL in health and several diseases as well as the status of past and ongoing attempts of therapeutic exploitation"--Publisher's description

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Pharmacology/Toxicology; Molecular Medicine; Human Physiology; Immunology; Cell Biology