Herpesviridae - A Look Into This Unique Family of Viruses

00_preface_Herpesviruses......Page 1 00x_part1......Page 11 01_Interferon, the Cell Cycle and Herpesvirus......Page 13 02_Optimal Gene Expression for Efficient Replication of Herpes Simplex Virus Type 1 (HSV-1)......Page 39 03_Trojan Horses and Fake Immunity Idols: Molecular Mimicry of Host Immune Mediators by Human Cytomegalovirus......Page 51 04_Contributions of the EBNA1 Protein of Epstein-Barr Virus Toward B-Cell Immortalization and Lymphomagenesis......Page 75 05_Kaposi’s Sarcoma-Associated Virus Governs Gene Expression Profiles Toward B Cell Transformation......Page 103 05x_part2......Page 115 06_Human Herpesviruses in Hematologic Diseases......Page 117 07_Zoster-Associated Pain and Post Herpetic Neuralgia......Page 147 08_Varicella Zoster Virus Infection in Pregnancy......Page 183 09_KSHV Paracrine Effects on Tumorigenesis......Page 203 09x_part3......Page 225 10_Herpesviruses of Fish, Amphibians and Invertebrates......Page 227 10x_part4......Page 253 11_Nucleoside and Nucleotide Analogues for the Treatment of Herpesvirus Infections: Current Stage and New Prospects in the Field of Acyclic Nucleoside Phosphonates......Page 255 12_Evidence-Based Treatment of Postherpetic Neuralgia......Page 281 13_Antiviral Activity of Lactoferrin and Ovotransferrin Derived Peptides Towards Herpesviridae......Page 305 Herpesviruses are unique among viruses as they encode for a complex self-regulatory system, aggressively invade and persist in the host, evade immune defense, alter all regulatory mechanisms of the macroorganism and modify the replication of heterologous viruses. Environmental factors influence these unconventional relationships. Consequently, a single herpesvirus species can be attributed to a wide range of diseases as etiological agents or cofactors. This book is intended to give an overview on selected clinical hot topics: herpes simplex virus encephalitis, persistent infection in the gingiva, thymidine kinase gene expression causing male infertility, and pharmaceutical reactivation of Epstein-Barr virus for oncolysis. Immune evasion mechanisms and new ways to formulate vaccines are exhaustively reviewed. Finally, a surprise: bovine herpesviruses could serve as models to study the pathomechanism of herpesviruses