Herbal Radiomodulators: Applications In Medicine, Homeland Defence And Space (cabi)

Despite years of research world-over, non-toxic and effective radiomodulators remain elusive. In recent years, there has been a shift towards the use of herbals, which are also apparently being viewed as sources of promising radiomodulatory drugs. This book discusses the potential of radiation countermeasure agents and radiosensitizers of herbal origin, their multifaceted mode of action, specifically the use of the former in a nuclear theatre of operations, rescue operations and deep space missions in addition to their application during radiotherapy. 41Zm0j1qIKL._SS500_.jpg 1 1845933958.pdf 2 Contents 6 Contributors 9 Preface 12 Foreword 14 Acknowledgements 17 About the Editor 18 SECTION I: Herbals for Radiomodulation (Radioprotection/Radiosensitization): An Overview 20 1 Radiomodulatory Compounds of Herbal Origin for New Frontiers in Medicine, Homeland Security, Management of Radiological Incidents and Space Applications 22 SECTION II: Phytomedicine for Radioprotection and Management of Radiation Injuries 44 2 Indian Medicinal Herbs and Ayurvedic Formulations as Potential Radioprotectors 46 3. Irradiation, Radioprotection and Nigella sativa 68 4. Modulation of Radiation-induced Damage by Serbian Natural Plant Products: Implications for Radioprotection 88 5. Phytoceuticals for Radioprotection with Special Reference to Egyptian Flora 104 6. Melatonin Mitigates the Damaging Effects of Ionizing Radiation 108 7. Radioprotective Effect of Citrus and Hawthorn Extracts against Genotoxicty Induced by Gamma Irradiation 122 8. The Healing Potential of Indigenous Essential Oils from New Zealand in the Prevention and Management of Radiation-induced Mucositis 130 SECTION III: Biological and Behavioural Radioprotection by Dietary Ingredients/Nutraceuticals 144 9. Piper betel Leaves: A Potential Gold Mine of Radioprotective and Photoprotective Compounds 146 10. Dietary Antioxidants and Phytochemicals in Radioprotection and Therapy 162 11. Effects of Berry Fruits on Neurocognitive Deficits Produced by Exposure to Space Radiation 172 12. Radioprotection by the Soy Isoflavone Genistein 184 13. Propolis and Related Flavonoids as Radioprotective Agents 196 SECTION IV: Elucidation of Mechanism of Action of Herbal Radioprotectors (A Stepping Stone for Designing of Novel Radiomodulators) 216 14. Radioprotective Effects of Ginkgo biloba via its Antioxidant Action 218 15. Novel Strategies for Protecting Mitochondria (the Cellular Powerhouse) against Low-LET Radiation: A Review 236 16. Andrographis paniculata: An Emerging Radioprotective Agent for Membrane Proteins 248 17. Mitigation of Deleterious Effects of Ionizing Radiation by Phytoceuticals: Mechanistic Studies with Centella asiatica 264 SECTION V: Cancer Therapy: The Role of Radiosensitizers of Natural Origin 274 18. The Radiosensitizing Effects of L-Canavanine 276 19. Withaferin A – A Phytosteroid of Promise for Tumour Sensitization in Cancer Therapy 292 20. The Radiosensitizer Hypericin as Adjuvant Therapy in the Treatment of Central Nervous System Tumours 300 21. Radiosensitizing Activity of the Indian Medicinal Plant Tinospora cordifolia Miers ex Hook F & Thoms in Tumour-bearing Mice 308 SECTION VI: Antioxidants and Radiotherapy: The Enigmatic Connection 326 22. Do Antioxidants Reduce the Efficacy of Radiotherapy? 328 INDEX 344 A 344 B 345 C 345 D 346 E 346 F 347 G 347 H 347 I 348 J 348 K 348 L 348 M 348 N 349 O 349 P 350 Q 351 R 351 S 352 T 352 U 353 V 353 W 353 X 353 Y 353 Z 353 Radiomodulatory compounds of herbal origin for new frontiers in medicine, homeland security, management of radiological incidents, and space applications / Rajesh Arora ... [et al.] Indian medicinal herbs and ayurvedic formulations as potential radioprotectors / D.K. Maurya and T.P.A. Devasagayam Irradiation, radioprotection, and Nigella sativa / M. Cemek ... [et al.] Modulation of radiation-induced damage by Serbian natural plant products : implications for radioprotection / Gordana Joksic, Andreja Leskovac, and S. Petronic Phytoceuticals for radioprotection with special reference to Egyptian flora / N.M. Abdel-Hamid Melatonin mitigates the damaging effects of ionizing radiation / Russel J. Reiter ... [et al.] Radioprotective effect of citrus and hawthorn extracts against genotoxicty-induced by gamma irradiation / Seyed Jalal Hosseinimehr The healing potential of indigenous essential oils from New Zealand in the prevention and management of radiation-induced mucositis / W. Maddocks-Jennings Piper betel leaves : a potential gold mine of radioprotective and photoprotective compounds / Debashish Banerjee and Subrata Chattopadhyay Dietary antioxidants and phytochemicals in radioprotection and therapy / Carmia Borek Diet as a factor in behavioural radioprotection following exposure to heavy particles / B.M. Rabin, James Joseph, and Barbara Shukitt-Halle Radioprotection by the soy isoflavone genistein / Michael R. Landauer Propolis and related flavonoids as radioprotective agents / Nada Orioli Radioprotective effects of Ginkgo biloba via antioxidant action / Goksel Sener, Abdullah Sakarcan, Berrak C. Yegen Strategies for protecting mitochondria (the cellular powerhouse) against low-let radiation : a review / Damodar Gupta ... [et al.] Andrographis paniculata : an emerging radioprotective agent for membrane proteins / Rakshamani Tripathi and Jayashree P. Kamat Mitigation of deleterious effects of ionizing radiation by phytoceuticals : mechanistic studies with Centella asiatica / C.K.K. Nair and Jisha Joy The radiosensitizing effects of L-canavanine / David R. Worthen and Peter A. Crooks Withaferin A : a phytosteroid of promise for tumour sensitization in cancer therapy / P. Uma Devi The radiosensitizer hypericin as adjuvant therapy in the treatment of central nervous system tumours / William Couldwell and Toba Niazi Radiosensitizing activity of the indian medicinal plant Tinospora cordifolia Miers ex h\ Hook f & Thoms in tumour-bearing mice / Ganesh Chandra Jagetia Do antioxidants reduce the efficacy of radiotherapy? / Ralph Moss. "This book discusses the potential of radiation countermeasure agents and radiosensitizers of herbal origin, and their multifaceted mode of action, particularly in nuclear operations, rescue operations, deep space missions, and application during radiotherapy. Comprising 22 chapters written by industry, clinical and academic experts, this book will appeal to readers in radiation biology, radiation oncology, military medicine, homeland defence, traditional, holistic and modern medicine, space biology, pharmacology and toxicology."--BOOK JACKET Discusses the potential of radiation countermeasure agents and radiosensitizers of herbal origin, and their multifaceted mode of action, particularly in nuclear operations, rescue operations, deep space missions, and application during radiotherapy. This book is suitable for readers in radiation biology, radiation oncology, and military medicine