Hepatitis C Virus: From Molecular Virology to Antiviral Therapy (Current Topics in Microbiology and Immunology Book 369)

Hepatitis C Virus (hcv), A Major Causative Agent Of Chronic Liver Disease, Is Spread Throughout The World And Around 170 Million People Are Persistently Infected. In This Volume, World-leading Experts In The Field Of Hcv Research Have Compiled The Most Recent Scientific Advances To Provide A Comprehensive And Very Timely Overview Of The Various Facets Of Hcv. The Book Starts With A Discussion Of The Possible Origin Of Hcv And Its Spread Among The Human Population. The Focus Of The Subsequent Chapters Is On Available Cell Culture And In Vivo Models Before Shifting To The Molecular And Cellular Principles Underlying The Viral Replication Cycle. These Chapters Are Complemented By Insightful Descriptions Of The Innate And Adaptive Immune Responses To Hcv As Well As The Virus-associated Pathogenesis. Finally, The Development Of Antiviral Therapies, Which Is Closely Linked With Progress In Basic Research, And The Implementation Of Those Therapies Into Present And Future Daily Clinical Practice Are Highlighted. The Origin Of Hepatitis C Virus / Peter Simmonds -- Cell Culture Systems For Hepatitis C Virus / Eike Steinmann And Thomas Pietschmann -- Animal Models For Hepatitis C / Eva Billerbeck ... [et Al.] -- Hepatitis C Virus Entry / Mirjam B. Zeisel, Daniel J. Felmlee And Thomas F. Baumert -- Hepatitis C Virus Proteins : From Structure To Function / Darius Moradpour And François Penin -- Hepatitis C Virus Rna Translation / Michael Niepmann -- Hepatitis C Virus Rna Replication / Volker Lohmann -- Virion Assembly And Release / Brett D. Lindenbach -- Innate Immune Responses To Hepatitis C Virus / John W. Schoggins And Charles M. Rice -- Adaptive Immune Responses In Hepatitis C Virus Infection / Christoph Neumann-haefelin And Robert Thimme -- Liver Injury And Disease Pathogenesis In Chronic Hepatitis C / Daisuke Yamane ... [et Al.] -- Hepatitis C Virus-specific Directly Acting Antiviral Drugs / Leen Delang ... [et Al.] -- Treatment Of Chronic Hepatitis C : Current And Future / Jean-michal Pawlotsky. Ralf Bartenschlager, Editor ; Responsible Series Editor, Peter Vogt. Includes Bibliographical References And Index. Front Matter....Pages i-viii The Origin of Hepatitis C Virus....Pages 1-15 Cell Culture Systems for Hepatitis C Virus....Pages 17-48 Animal Models for Hepatitis C....Pages 49-86 Hepatitis C Virus Entry....Pages 87-112 Hepatitis C Virus Proteins: From Structure to Function....Pages 113-142 Hepatitis C Virus RNA Translation....Pages 143-166 Hepatitis C Virus RNA Replication....Pages 167-198 Virion Assembly and Release....Pages 199-218 Innate Immune Responses to Hepatitis C Virus....Pages 219-242 Adaptive Immune Responses in Hepatitis C Virus Infection....Pages 243-262 Liver Injury and Disease Pathogenesis in Chronic Hepatitis C....Pages 263-288 Hepatitis C Virus-Specific Directly Acting Antiviral Drugs....Pages 289-320 Treatment of Chronic Hepatitis C: Current and Future....Pages 321-342 Back Matter....Pages 343-346