Hepatic Transport Of Organic Substances (proceedings In Life Sciences)

Hepatic cells are involved in the metabolization and elimination of a variety of endogenous and exogenous substances. They mediate the uptake, processing and subsequent secretion of biliary compounds, such as various drugs or hormones, and the passage of metabolites to be released into different blood compartments. To perform vectorial passages hepatocytes show a strong polarity with sites for endocytotic processes or specific carrier molecules, and a specified system of organelles for intracellular transport and sorting, metabolization and secretion of compounds. Several aspects, e.g. regulation, control and mechanisms of hepatic traffic are reported in detail - complemented by methodological approaches to analyse and monitor these processes. Front Matter....Pages I-XV Front Matter....Pages 1-1 Glutamate-sodium Cotransport in the Kidney: An Example for the Plasticity of Transport Systems....Pages 3-11 Energetic Coupling in Secondary Active Transport....Pages 12-20 The Passage of Molecules into Bile: Paracellular and Transcytotic Pathways....Pages 21-32 Increase in Paracellular Permeability as a Pathophysiological Principle of Drug-Induced Intrahepatic Cholestasis in Rats....Pages 33-34 The Hepatocyte’s Plasma Membrane Domains. Interrelations with the Endocytic Compartment....Pages 35-44 Hepatic Spaces and Transport in the Perfused Liver....Pages 45-57 New Methodologic Approaches for the Study of Transport in the Liver....Pages 58-73 Transport Processes in Mammalian Gallbladder and Bile Duct....Pages 74-84 Transcellular Butyrate Transport in Gallbladder Epithelium....Pages 85-86 Accessibility of Primary Bile in Liver Cell Culture....Pages 87-88 Polarity of the Hepatocyte Surface Membrane: Influence of Lipids on Protein Function....Pages 89-101 ATP in and Around the Bile Canaliculus....Pages 102-117 Front Matter....Pages 119-119 Glutathione Conjugate Transport in Hepatic Elimination of Electrophiles....Pages 121-130 Hepatobiliary Cysteinyl Leukotriene Elimination....Pages 131-140 Biliary Excretion of Thiols and Their Role in Elimination of Methylmercury....Pages 141-153 Glutamine and Glutamate Transport in Perfused Liver....Pages 157-166 Regulation of Hepatic Amino Acid Transport and Partial Purification of the System A Carrier....Pages 167-176 Hormonal Control of Amino Acid Transport Systems in Cultured Periportal and Perivenous Hepatocytes....Pages 177-187 Differential Inactivation of System A in Normal and Transformed Liver Cells....Pages 188-189 Mechanism of Renal Transport of L-Alanine in Luminal Membrane Vesicles....Pages 190-191 Front Matter....Pages 119-119 Characteristics of Organic Anion Binding Proteins from Rat Liver Sinusoidal Plasma Membranes....Pages 195-210 Mechanism of Hepatic Fatty Acid Uptake....Pages 211-220 Studies on the Mechanism of Organic Anion Transport by the Liver....Pages 221-232 Mechanisms of Sinusoidal Bile Acid Transport....Pages 233-239 Binding and Uptake of Taurocholate in Subcellular Organelles from Rat Liver....Pages 240-256 The Ontogeny of Hepatic Bile Acid Transport....Pages 257-266 Identification and Function of Bile Salt Binding Polypeptides of Hepatocyte Membrane....Pages 267-278 Characterization of the Bile Acid Transport System in Normal and Transformed Hepatocytes Using Monoclonal Antibodies....Pages 279-285 Transport of Bile Salts Across the Canalicular Plasma Membrane....Pages 286-294 Biliary Taurocholate Excretion During the Metabolism of 2-Methyl-1, 4-Naphthoquinone (Menadione) in Perfused Rat Liver....Pages 295-296 Comparison of Bile Salt-Binding Proteins in Basolateral Membranes from Small Intestine, Kidney, and Liver....Pages 297-298 Effects of Hydrostatic Pressure and Liver Cell Membrane Potential on Hepatic Bile Acid Transport....Pages 299-300 Characterization and Purification of Bile Acid Transport Proteins....Pages 301-302 Transport of Taurocholate in Isolated Cells from Ileum, Liver and Kidney....Pages 303-304 Properties of the Taurocholate Uptake System in Basolateral Rat Liver Plasma Membrane Vesicles: Effects of Albumin and Substrate Specificity....Pages 305-306 Uptake of Foreign Cyclopeptides by Liver Cells....Pages 309-316 Identification of Carrier Proteins in Hepatocytes by (Photo) Affinity Labels Derived from Foreign Cyclopeptides....Pages 317-326 Uptake of Xenobiotics by the Bile Acid Transport System in the Liver: Relationship Between the Organic Anion Transport Systems in the Kidney and the Liver....Pages 327-343 Mechanisms for Hepato-Biliary Transport of Cationic Drugs Studied with the Intact Organ and on the Membrane Level....Pages 344-367 The Role of Liver and Extrahepatic Organs in the Metabolism of N-Nitrosodibutylamine (NDBA): Comparison of in Vitro with in Vivo Data....Pages 368-369 Front Matter....Pages 119-119 The Role of Biliary Excretion and Intestinal Metabolism for Toxokinetics and Toxicity of T-2 Toxin, a Major Trichothecene Mycotoxin....Pages 370-371 Binding Proteins for Dipeptides, β-Lactam Antibiotics, and p-Aminohippurate (PAH) in Plasma Membranes from Small Intestine and Kidney....Pages 372-373 Transport Properties of Steroid Glucuronides....Pages 377-387 Intestinal Transport of Glucuronides and Sulpho-Conjugates....Pages 388-389 Transport of Thyroid Hormone (TH) into Hepatocytes....Pages 390-402 Metabolism of Thyroid Hormone in Liver....Pages 403-404 Concluding Remarks....Pages 405-410 Back Matter....Pages 411-435 Proceedings of a Symposium, held May 8-11, 1988 at Schloß Ringberg, Rottach Egern