Hematopoietic Stem Cell Biology (Stem Cell Biology and Regenerative Medicine)

Hematopoietic Stem Cell Biology is the newest installment in the Stem Cell Biology and Regenerative Medicine series, to which it adeptly contributes as it offers a selection of carefully chosen topics so that the readers can understand recent advances in the field of the hematopoietic stem cells and hemato/lymphopoiesis. Each chapter is not a simple review of the topic, but rather an in-depth insight, which allows the reader to attain a multifaceted knowledgebase on hematopoietic stem cells. The chapters, which are authored by the leading experts in the field, cover characteristics of the hematopoietic stem cells at the cellular and molecular levels, offers details in regulatory mechanisms of differentiation mechanisms of hematopoietic stem cells to more mature blood cell, and discusses abnormal hematopoiesis that leads to leukemia. Hematopoietic Stem Cell Biology serves the inquiring minds of researchers, graduate students and post doctorate fellows as it expertly addresses the ever-growing field of hematopoietic stem cells and hemato/lymphopoiesis. In the summer of 1988, my developmental biology professor announced to the class that hematopoietic stem cells (HSCs) had finally been purified. Somehow, I never forgot the professor's words. When I started working in Dr. Irv Weissman's labo- tory at Stanford as a postdoctoral fellow, I realized that the findings mentioned by the professor were from Weissman's laboratory and had been published in a 1988 edition of the journal Science. It has been over 20 years since the publication of that seminal paper, and since then tremendous advances in understanding the biology and maturation of HSCs, namely the process of hematopoiesis, which includes lymphocyte development, have been made. These discoveries were made possible in part by advancements in technology. For example, recent availability of user friendly fluorescence activated cell sorting (FACS) machines and monoclonal an- bodies with a variety of fluorescent labels has allowed more scientists to sort and analyze rare populations in the bone marrow, such as HSCs. All classes of hematopoietic cells are derived from HSCs. Stem cell biology draws enormous attention not only from scientists, but also from ordinary people because of the tremendous potential for development of new therapeutic application to diseases that currently lack any type of effective therapy. Thus, this type of “regenerative medicine” is a relatively new and attractive field in both basic science and clinical medicine. Front Matter....Pages 1-11 Principles of Hematopoietic Stem Cell Biology....Pages 1-36 Hematopoietic Stem Cells and Their Niche....Pages 37-55 Hematopoietic Stem Cells and Somatic Stem Cells....Pages 57-92 Developmental Biology of Mammalian T-Cell Progenitors: From Early Lymphoid Progenitors to Thymus-Colonizing Cells....Pages 93-116 GATA1 and GATA2 Function in Hematopoietic Differentiation....Pages 117-142 Role of the IL-7 Receptor in γδ T-Cell Development from Hematopoietic Stem Cells....Pages 143-159 Dendritic Cell Homeostasis: Physiology and Impact on Disease....Pages 161-212 Wnt in Hematopoietic and Leukemic Stem Cells....Pages 213-243 Back Matter....Pages 1-7

this Book Is Written By Experts In The Field Of Hematopoietic Stem Cell Biology And Lymphocyte Development In Order To Overview Recent Advances In The Field. Prospective Isolation Of Various Progenitors And Stem Cells Enables Us To Understand Self-renewal Mechanisms Of Stem Cells As Well As Regulation Of Hematopoiesis. Furthermore, The Importance Of Extrinsic Factors Has Been Emphasized Recently. This Volume Concisely Describes Our Current Understanding Of Normal Hemato/lymphopoiesis As Well As Abnormal Hematopoiesis, Which May Lead To Leukemia.

Prospective isolation of various progenitors and stem cells enables us to understand self-renewal mechanisms of stem cells as well as regulation of hematopoiesis. This book describes our understanding of normal hemato/lymphopoiesis as well as abnormal hematopoiesis, which may lead to leukemia