Heat Shock Proteins: Potent Mediators of Inflammation and Immunity (Heat Shock Proteins, 1)

Heat Shock Proteins: Potent Mediators of Inflammation and Immunity currently provides the most up-to-date review on new mechanisms and provides exciting insights into how heat shock proteins modulates the hosts immune response. Written by leaders in the field of heat shock protein immunobiology, the chapters systematically and in a step wise fashion takes the reader through the fascinating sequence of events by which heat shock proteins activate immune responses and provides answers as to its biological significance to the host. From the early stages of binding and receptors-mediated signalling, to new paradigms by which heat shock proteins are released into the circulation, to antigen processing and presentation, and finally to the immune response itself this book is a must read for graduate and postgraduates in the field of Biology (plant and mammal), Biochemistry (pro- and eukaryotic), Immunology, Microbiology, Exercise Medicine, Physiology, Inflammatory diseases, Autoimmunity, Pharmacology and Pathology. Front Matter....Pages I-XII Front Matter....Pages 1-1 Release of Heat Shock Proteins: Passive Versus Active Release Mechanisms....Pages 3-20 Hsp70 Peptide Acting as a Danger Signal for Natural Killer (NK) Cells....Pages 21-30 Mechanisms of Stress-Induced Cellular Hsp72 Release....Pages 31-37 Roles of Extracellular Heat Shock Proteins: A New Sense of Danger....Pages 39-57 Front Matter....Pages 59-59 Macrophages and the Stress Response....Pages 61-73 Heat Shock Proteins and Scavenger Receptors....Pages 75-94 The Inside Story: Anti-Inflammatory roles of HSF1 and heat shock proteins....Pages 95-113 Interaction of Heat Shock Protein 60 with Innate Immune Cells....Pages 115-128 Front Matter....Pages 129-129 HSP-APC Interactions: Initiation of Immune Responses....Pages 131-145 Extracellular Functions for an Intracellular Protein: GRP94/GP96 Interactions with the Mammalian Immune System....Pages 147-158 Hsp-Induced Stimulation of Immune Responses....Pages 159-172 The Role of Heat Shock Proteins in the Elicitation of Immune Responses....Pages 173-187 Hsp70 Family Members, Danger Signals and Autoimmunity....Pages 189-211 The Immune Response Under Stress: Class I HLA Presentation of Host-Derived Peptides....Pages 213-234 Extracellular Hsp 72: A Double-Edged Sword for Host Defense....Pages 235-263 HSP60: A Pleiotropic Immune Signal....Pages 265-272 Front Matter....Pages 273-273 Impact of HSP-Chaperoned Peptides on the MHC Class II-Dependent Presentation and Activation of CD4 + T Cells in Regard of Allo- and Autoantigens....Pages 275-288 Heat Shock Proteins are Targets for T Cell Regulation: How Microbial HSP Induce IL10 Producing Anti-Inflammatory T Cells....Pages 289-308 The Pro- and Anti-Inflammatory Properties of the Stress Protein GP96....Pages 309-320 Anti-Tumor Response and Heat Shock Proteins (HSP): A friend or Foe relationship?....Pages 321-336 Front Matter....Pages 273-273 Heat Shock Proteins and the Resolution of Inflammation by Lymphocytes....Pages 337-354 Back Matter....Pages 355-357 Mechanisms Of Heat Shock Protein Release -- Release Of Heat Shock Proteins: Passive Versus Active Release Mechanisms -- Hsp70 Peptide Acting As A Danger Signal For Natural Killer (nk) Cells -- Mechanisms Of Stress-induced Cellular Hsp72 Release -- Roles Of Extracellular Heat Shock Proteins: A New Sense Of Danger -- Heat Shock Protein Binding And Receptor-mediated Signaling -- Macrophages And The Stress Response -- Heat Shock Proteins And Scavenger Receptors -- The Inside Story: Anti-inflammatory Roles Of Hsf1 And Heat Shock Proteins -- Interaction Of Heat Shock Protein 60 With Innate Immune Cells -- Immune Responses Elicited By Heat Shock Proteins -- Hsp-apc Interactions: Initiation Of Immune Responses -- Extracellular Functions For An Intracellular Protein: Grp94/gp96 Interactions With The Mammalian Immune System -- Hsp-induced Stimulation Of Immune Responses -- The Role Of Heat Shock Proteins In The Elicitation Of Immune Responses -- Hsp70 Family Members, Danger Signals, And Autoimmunity -- The Immune Response Under Stress: Class I Hla Presentation Of Host-derived Peptides -- Extracellular Hsp72: A Double-edged Sword For Host Defense -- Hsp60: A Pleiotropic Immune Signal -- Antigen Processing, Presentation And Effect On Inflammation And Disease -- Impact Of Hsp-chaperoned Peptides On The Mhc Class Ii-dependent Presentation And Activation Of Cd4+ T Cells In Regard Of Allo- And Autoantigens -- Heat Shock Proteins Are Targets For T Cell Regulation: How Microbial Hsp Induce Il10 Producing Anti-inflammatory T Cells -- The Pro- And Anti-inflammatory Properties Of The Stress Protein Gp96 -- Anti-tumor Response And Heat Shock Proteins (hsp): A Friend Or Foe Relationship? -- Heat Shock Proteins And The Resolution Of Inflammation By Lymphocytes. Edited By Alexzander A.a. Asea And Antonio De Maio. Includes Bibliographical References And Index. Heat Shock Proteins: Potent Mediators of Inflammation and Immunity Currently provides the most up-to-date review on new mechanisms and provides exciting insights into how heat shock proteins modulate the hosts immune response. Written by leaders in the field of heat shock protein immunobiology, the chapters systematically and in a step wise fashion takes the reader through the fascinating sequence of events by which heat shock proteins activate immune responses and provides answers as to its biological significance to the host. From the early stages of binding and receptors mediated signalling, to new paradigms by which heat shock proteins are released into the circulation, to antigen processing and presentation, and finally to the immune response itself this book is a must read for graduates and postgraduates in the field of Biology (plant and mammal), Biochemistry (pro- and eukaryotic), Immunology, Microbiology, Exercise Medicine, Physiology, Inflammatory diseases, Autoimmunity, Pharmacology and Pathology