Handbook of the Hemopoietic Microenvironment (Contemporary Biomedicine, 9)

In 1868, Ernst Neumann recognized that blood cells re­ quire continuous replenishment during postnata1life. Before him, the assumption was that cells of the blood, like nerves once formed in the embryo, remain in the body throughout life. Neumann also recognized that this process occurred within the bone marrow, because this tissue provided a fa­ vorable environment for proliferation and differentiation of blood cell precursors. Vera Danchakoff, the Russian embryologist working in the US, in 1916 made an analogy to the soil and the seed. Bone marrow forms the soil, providing a favorable environment for the growth of seed, the hemopoietic stem cell, and other progenitor cells. Imagine in the remote past a heap of similar tree seeds. These seeds develop in our moderate climate into a tall and many branched tree. Suppose the wind bears a part of the seeds away and brings them to a land possessing different environmental conditions, we will say the arc­ tic lands. There the seeds may develop but they may pro­ duce trees no higher than our moss. Front Matter....Pages i-xxii Hemopoietic Microenvironments....Pages 1-86 Molecular and Cellular Traffic Across the Marrow Sinuses....Pages 87-140 In Vivo Microscopy of Hemopoietic Tissue....Pages 141-155 Fatty Involution of Marrow and the Role of Adipose Tissue in Hemopoiesis....Pages 157-187 Hematopoiesis on Artificial Membranes....Pages 189-218 Cellular Components of Stroma In Vivo In Comparison With In Vitro Systems....Pages 219-251 Stromal Cells in Long-Term Bone Marrow Cultures....Pages 253-285 Cultured Stromal Cell Lines from Hemopoietic Tissues....Pages 287-333 Cellular Interactions in the Regulation of Human Hemopoiesis In Vitro....Pages 335-368 The Collagenous Hemopoietic Microenvironment....Pages 369-398 The Hemopoietic Extracellular Matrix....Pages 399-432 Bone Marrow Microenvironment....Pages 433-444 Back Matter....Pages 445-453