Handbook of the Biology of Aging, Eighth Edition

__Handbook of the Biology of Aging, Eighth Edition,__ provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others. * Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition * Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline * Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline * Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering * New chapters on genetics, evolutionary biology, bone aging, and epigenetic control * Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions Content: Front-matter,Copyright,Foreword,Preface,About the Editors,List of ContributorsEntitled to full textPart I: Basic Mechanisms of Aging: Models and SystemsChapter 1 - Longevity as a Complex Genetic Trait, Pages 3-54, George L. Sutphin, Ron Korstanje Chapter 2 - The mTOR Pathway and Aging, Pages 55-81, Katherine H. Schreiber, Monique N. O’Leary, Brian K. Kennedy Chapter 3 - Sirtuins, Healthspan, and Longevity in Mammals, Pages 83-132, William Giblin, David B. Lombard Chapter 4 - The Hypoxic Response and Aging, Pages 133-159, Scott F. Leiser, Hillary A. Miller, Matt Kaeberlein Chapter 5 - The Role of Neurosensory Systems in the Modulation of Aging, Pages 161-178, Michael J. Waterson, Scott D. Pletcher Chapter 6 - The Naked Mole-Rat: A Resilient Rodent Model of Aging, Longevity, and Healthspan, Pages 179-204, Kaitlyn N. Lewis, Rochelle Buffenstein Chapter 7 - Contributions of Telomere Biology to Human Age-Related Disease, Pages 205-239, Ting-Lin B. Yang, Shufei Song, F. Brad Johnson Chapter 8 - Systems Approaches to Understanding Aging, Pages 241-261, Lei Hou, Dan Wang, Hao Cheng, Bo Xian, Jing-Dong J Han Chapter 9 - Integrative Genomics of Aging, Pages 263-285, João Pedro de Magalhães, Robi Tacutu Chapter 10 - NIA Interventions Testing Program: A Collaborative Approach for Investigating Interventions to Promote Healthy Aging, Pages 287-303, Nancy L. Nadon, Richard A. Miller, Randy Strong, David E. Harrison Chapter 11 - Comparative Biology of Aging: Insights from Long-Lived Rodent Species, Pages 305-324, Michael Van Meter, Vera Gorbunova, Andrei Seluanov Chapter 12 - Genetics of Human Aging, Pages 327-358, Miook Cho, Yousin Suh Chapter 13 - The Aging Arterial Wall, Pages 359-389, Mingyi Wang, Robert E. Monticone, Edward G. Lakatta Chapter 14 - Age-Related Alterations in Neural Plasticity, Pages 391-405, Shannon J. Moore, Geoffrey G. Murphy Chapter 15 - The Aging Immune System: Dysregulation, Compensatory Mechanisms, and Prospects for Intervention, Pages 407-431, Ludmila Müller, Graham Pawelec Chapter 16 - Vascular Disease in Hutchinson Gilford Progeria Syndrome and Aging: Common Phenotypes and Potential Mechanisms*, Pages 433-457, Ingrid A. Harten, Michelle Olive, Thomas N. Wight Chapter 17 - Cardiac Aging, Pages 459-494, Dao-Fu Dai, Ying-Ann Chiao, Robert J. Wessells, Rolf Bodmer, Hazel H. Szeto, Peter S. Rabinovitch Chapter 18 - Current Status of Research on Trends in Morbidity, Healthy Life Expectancy, and the Compression of Morbidity, Pages 495-505, Eileen M. Crimmins, Morgan E. Levine Chapter 19 - On the Compression of Morbidity: From 1980 to 2015 and Beyond, Pages 507-524, James F. Fries Author Index, Pages 525-541 Subject Index, Pages 543-559

Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems.

The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others.

• Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition
• Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline
• Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline
• Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering
• New chapters on genetics, evolutionary biology, bone aging, and epigenetic control
• Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions

This seventh edition provides a comprehensive overview of the latest research findings in the biology of aging. Intended as a summary for researchers, it may also be used as a high level textbook for graduate and upper level undergraduate courses