Handbook of Statistics, Volume 27: Epidemiology and Medical Statistics (Handbook of Statistics) (Handbook of Statistics)

This volume, representing a compilation of authoritative reviews on a multitude of uses of statistics in epidemiology and medical statistics written by internationally renowned experts, is addressed to statisticians working in biomedical and epidemiological fields who use statistical and quantitative methods in their work. While the use of statistics in these fields has a long and rich history, explosive growth of science in general and clinical and epidemiological sciences in particular have gone through a see of change, spawning the development of new methods and innovative adaptations of standard methods. Since the literature is highly scattered, the Editors have undertaken this humble exercise to document a representative collection of topics of broad interest to diverse users. The volume spans a cross section of standard topics oriented toward users in the current evolving field, as well as special topics in much need which have more recent origins. This volume was prepared especially keeping the applied statisticians in mind, emphasizing applications-oriented methods and techniques, including references to appropriate software when relevant. · Contributors are internationally renowned experts in their respective areas · Addresses emerging statistical challenges in epidemiological, biomedical, and pharmaceutical research · Methods for assessing Biomarkers, analysis of competing risks · Clinical trials including sequential and group sequential, crossover designs, cluster randomized, and adaptive designs · Structural equations modelling and longitudinal data analysis Epidemiology and Medical Statistics......Page 4 Table of contents......Page 6 Preface......Page 14 Contributors......Page 15 1. Statistical Methods and Challenges in Epidemiology and Biomedical Research......Page 20 2. Statistical Inference for Causal Effects, With Emphasis on Applications in Epidemiology and Medical Statistics......Page 47 3. Epidemiologic Study Designs......Page 83 4. Statistical Methods for Assessing Biomarkers and Analyzing Biomarker Data......Page 128 5. Linear and Non-Linear Regression Methods in Epidemiology and Biostatistics......Page 167 6. Logistic Regression......Page 206 7. Count Response Regression Models......Page 229 8. Mixed Models......Page 272 9. Survival Analysis......Page 300 10. A Review of Statistical Analyses for Competing Risks......Page 340 11. Cluster Analysis......Page 361 12. Factor Analysis and Related Methods......Page 386 13. Structural Equation Modeling......Page 414 14. Statistical Modeling in Biomedical Research: Longitudinal Data Analysis......Page 448 15. Design and Analysis of Cross-Over Trials......Page 483 16. Sequential and Group Sequential Designs in Clinical Trials: Guidelines for Practitioners......Page 510 17. Early Phase Clinical Trials: Phases I and II......Page 532 18. Definitive Phase III and Phase IV Clinical Trials......Page 564 19. Incomplete Data in Epidemiology and Medical Statistics......Page 588 20. Meta-Analysis......Page 621 21. The Multiple Comparison Issue in Health Care Research......Page 635 22. Power: Establishing the Optimum Sample Size......Page 675 23. Statistical Learning in Medical Data Analysis......Page 698 24. Evidence Based Medicine and Medical Decision Making......Page 731 25. Estimation of Marginal Regression Models with Multiple Source Predictors......Page 749 26. Difference Equations with Public Health Applications......Page 766 27. The Bayesian Approach to Experimental Data Analysis......Page 794 Subject Index......Page 831 Handbook of Statistics: Contents of Previous Volumes......Page 842 This volume, representing a compilation of authoritative reviews on a multitude of uses of statistics in epidemiology and medical statistics written by internationally renowned experts, is addressed to statisticians working in biomedical and epidemiological fields who use statistical and quantitative methods in their work. While the use of statistics in these fields has a long and rich history, explosive growth of science in general and clinical and epidemiological sciences in particular have gone through a see of change, spawning the development of new methods and innovative adaptations of standard methods. Since the literature is highly scattered, the Editors have undertaken this humble exercise to document a representative collection of topics of broad interest to diverse users. The volume spans a cross section of standard topics oriented toward users in the current evolving field, as well as special topics in much need which have more recent origins. This volume was prepared especially keeping the applied statisticians in mind, emphasizing applications-oriented methods and techniques, including references to appropriate software when relevant.

· Contributors are internationally renowned experts in their respective areas
· Addresses emerging statistical challenges in epidemiological, biomedical, and pharmaceutical research
· Methods for assessing Biomarkers, analysis of competing risks
· Clinical trials including sequential and group sequential, crossover designs, cluster randomized, and adaptive designs
· Structural equations modelling and longitudinal data analysis This volume, representing a compilation of authoritative reviews on a multitude of uses of statistics in epidemiology and medical statistics written by internationally renowned experts, is addressed to statisticians working in biomedical and epidemiological fields who use statistical and quantitative methods in their work. While the use of statistics in these fields has a long and rich history, explosive growth of science in general and clinical and epidemiological sciences in particular have gone through a see of change, spawning the development of new methods and innovative adaptations of standard methods. Since the literature is highly scattered, the Editors have undertaken this humble exercise to document a representative collection of topics of broad interest to diverse users. The volume spans a cross section of standard topics oriented toward users in the current evolving field, as well as special topics in much need which have more recent origins. This volume was prepared especially keeping the applied statisticians in mind, emphasizing applications-oriented methods and techniques, including references to appropriate software when relevant.A Contributors are internationally renowned experts in their respective areasA Addresses emerging statistical challenges in epidemiological, biomedical, and pharmaceutical researchA Methods for assessing Biomarkers, analysis of competing risksA Clinical trials including sequential and group sequential, crossover designs, cluster randomized, and adaptive designsA Structural equations modelling and longitudinal data analysis" Addresses emerging statistical challenges in epidemiological, biomedical, and pharmaceutical research. This volume features: methods for assessing Biomarkers, analysis of competing risks; clinical trials including sequential and group sequential, crossover designs, cluster randomized, and adaptive designs; and, structural equations modelling.