Handbook of Research on Systems Biology Applications in Medicine

'This book highlights the use of systems approaches including genomic, cellular, proteomic, metabolomic, bioinformatics, molecular, and biochemical, to address fundamental questions in complex diseases like cancer diabetes but also in ageing'--Provided by publisher. Title......Page 2 Editorial Advisory Board......Page 4 List of Contributors......Page 5 Table of Contents......Page 8 Detailed Table of Contents......Page 16 Foreword......Page 34 Preface......Page 36 Acknowledgment......Page 41 Pathway Biology Approach to Medicine......Page 44 Systems and Control Theory for Medical Systems Biology......Page 54 Mathematical Description of Time Delays in Pathways Cross Talk......Page 70 Deterministic Modeling in Medicine......Page 117 Synthetic Biology as a Proof of Systems Biology......Page 140 Computational Models for the Analysis of Modern Biological Data......Page 160 Computer Aided Knowledge Discovery in Biomedicine......Page 169 Function and Homology of Proteins Similar in Sequence: Phylogenetic Profiling......Page 186 Computational Methods for the Prediction of GPCRs Coupling Selectivity......Page 210 Bacterial β-Barrel Outer Membrane Proteins: A Common Structural Theme Implicated in a Wide Variety of Functional Roles......Page 225 Clustering Methods for Gene-Expression Data......Page 252 Uncovering Fine Structure in Gene Expression Profile by Maximum Entropy Modeling of cDNA Microarray Images and Kernel Density Methods......Page 264 Gene Expression Profiling with the BeadArray Platform......Page 282 The Affymetrix GeneChip® Microarray Platform......Page 294 Alternative Isoform Detection Using Exon Arrays......Page 305 Gene Expression in Microbial Systems for Growth and Metabolism......Page 321 Alternative Splicing and Disease......Page 334 Mathematical Modeling of the Aging Process......Page 355 The Sebaceous Gland: A Model of Hormonal Aging......Page 374 Systems Biology Applied to Cancer Research......Page 382 Systems Biology Strategies in Studies of Energy Homeostasis In Vivo......Page 397 Approaching Type 2 Diabetes Mellitus by Systems Biology......Page 404 Systems Biology and Infectious Diseases......Page 420 Systems Biology of Human-Pathogenic Fungi......Page 446 Development of Specific Gamma Secretase Inhibitors......Page 466 In Machina Systems for the Rational De Novo Peptide Design......Page 481 Applications of Metabolic Flux Balancing in Medicine......Page 501 Multi-Level Data Integration and Data Mining in Systems Biology......Page 519 Methods for Reverse Engineering of Gene Regulatory Networks......Page 540 Data Integration for Regulatory Gene Module Discovery......Page 559 Discrete Networks as a Suitable Approach for the Analysis of Genetic Regulation......Page 573 Investigating the Collective Behavior of Neural Networks: A Review of Signal Processing Approaches......Page 584 The System for Population Kinetics: Open Source Software for Population Analysis......Page 599 Photosynthesis: How Proteins Control Excitation Energy Transfer......Page 616 Photodynamic Therapy: A Systems Biology Approach......Page 631 Modeling of Porphyrin Metabolism with PyBioS......Page 686 Interference Microscopy for Cellular Studies......Page 699 Fluorescence Imaging of Mitochondrial Long-Term Depolarization in Cancer Cells Exposed to Heat-Stress......Page 716 Protein Interactions and Diseases......Page 737 The Breadth and Depth of BioMedical Molecular Networks: The Reactome Perspective......Page 757 Entropy and Thermodynamics in Biomolecular Simulation......Page 774 Model Development and Decomposition in Physiology......Page 802 A Pandemic Avian Influenza Mathematical Model......Page 841 Dengue Fever: A Mathematical Model with Immunization Program......Page 852 Automated Image Analysis Approaches in Histopathology......Page 869 About the Contributors......Page 894 Index......Page 912 Systems biology is the study of the interactions between the components of a biological system and the way these interactions lead to a specific function and behavior of that system. The Handbook of Research on Systems Biology Applications in Medicine presents concepts of the applications of systems biology in medicine, leading students and advanced researchers to an understanding of current ideas in the complex field of systems biology, analysis of data, and development of models, simulation, and drug development. With over 50 incisive research contributions from international experts, this unsurpassed compendium of critical research is an indispensable resource for medical libraries worldwide.