Handbook of Proteolytic Enzymes (Handbook of Proteolytic Enzymes, Two-Volume Set with CD-ROM)

Extensively revised and updated, the new edition of the highly regarded Handbook of Proteolytic Enzymes is an essential reference for biochemists, biotechnologists and molecular biologists. Edited by world-renowned experts in the field, this comprehensive work provides detailed information on all known proteolytic enzymes to date. This two-volume set unveils new developments on proteolytic enzymes which are being investigatedin pharmaceutical research for such diseases as HIV, Hepatitis C, and the common cold. Volume I covers aspartic and metallo petidases while Volume II examines peptidases of cysteine, serine, threonine and unknown catalytic type. A CD-ROM accompanies the book containing fully searchable text, specialised scissile bond searches, 3-D color structures and much more. The only comprehensive book on proteolytic enzymes Includes 671 chapters, each written by experts in their field, on proteolytic enzymes from all groups of living organisms and the viruses, including those that are currently major targets of pharmaceutical research Accompanying CD-ROM provides fully searchable text, 2D structures of peptidases in color and links directly to PubMed and MEROPS databases Each chapter describes in detail the enzyme name, its history, activity and specificity, structural chemistry, preparation, biological aspects and distinguishing features Over 1000 peptidases included Content: Front-matter , Pages i,iii Copyright , Page iv Editor Biographies , Page xxxiii Contributors , Pages xxxv-xlviii Preface , Page xlix Introduction , Pages li-liv Chapter 1 - Introduction: Aspartic and Glutamic Peptidases and Their Clans , Pages 3-19 Chapter 2 - Catalytic Pathways of Aspartic Peptidases , Pages 19-26 Chapter 3 - Pepsin A , Pages 27-35 Chapter 4 - Pepsin B , Pages 36-37 Chapter 5 - Chymosin , Pages 37-42 Chapter 6 - Cathepsin E , Pages 42-49 Chapter 7 - Gastricsin , Pages 49-54 Chapter 8 - Cathepsin D , Pages 54-63 Chapter 9 - Nothepsin , Pages 63-69 Chapter 10 - Napsin A , Pages 69-71 Chapter 11 - Renin , Pages 71-82 Chapter 12 - Mouse Submandibular Renin , Pages 82-85 Chapter 13 - Memapsin 1 , Pages 85-87 Chapter 14 - Memapsin 2 , Pages 87-93 Chapter 15 - Pregnancy-Associated Glycoproteins , Pages 93-96 Chapter 16 - Pepsin F , Pages 96-98 Chapter 17 - Food Vacuole Plasmepsins , Pages 98-103 Chapter 18 - Plasmepsin V , Pages 103-105 Chapter 19 - Histo-Aspartic Proteinase , Pages 105-108 Chapter 20 - Tick Heme-Binding Aspartic Proteinase , Pages 108-109 Chapter 21 - Yolk Cathepsin ( Boophilus sp.) , Pages 110-112 Chapter 22 - Na -APR-1 (aka Necepsin-2) , Pages 113-118 Chapter 23 - Phytepsin , Pages 118-124 Chapter 24 - Nepenthesin , Pages 125-128 Chapter 25 - Saccharopepsin , Pages 128-133 Chapter 26 - Acrocylindropepsin , Page 134 Chapter 27 - Aspergillopepsin I , Pages 135-141 Chapter 28 - Penicillopepsin , Pages 141-146 Chapter 29 - Endothiapepsin , Pages 147-150 Chapter 30 - Rhizopuspepsin , Pages 151-154 Chapter 31 - Mucorpepsin , Pages 154-156 Chapter 32 - Polyporopepsin , Pages 157-158 Chapter 33 - Candidapepsin , Pages 159-166 Chapter 34 - Candidaparapsin , Pages 166-169 Chapter 35 - Canditropsin , Pages 169-172 Chapter 36 - Syncephapepsin , Pages 172-173 Chapter 37 - Barrierpepsin , Pages 174-176 Chapter 38 - Yapsin 1 , Pages 176-180 Chapter 39 - Yapsin 2 , Pages 180-182 Chapter 40 - Yapsin A , Pages 183-184 Chapter 41 - Rhodotorulapepsin , Pages 185-186 Chapter 42 - Cladosporopepsin , Pages 186-187 Chapter 43 - Pycnoporopepsin , Pages 187-190 Chapter 44 - Human Immunodeficiency Virus 1 Retropepsin , Pages 190-199 Chapter 45 - Human Immunodeficiency Virus 2 Retropepsin , Pages 199-204 Chapter 46 - Simian Immunodeficiency Virus Retropepsin , Pages 204-207 Chapter 47 - Equine Infectious Anemia Virus Retropepsin , Pages 207-210 Chapter 48 - Rous Sarcoma Virus Retropepsin and Avian Myeloblastosis Virus Retropepsin , Pages 210-213 Chapter 49 - Human T-cell Leukemia Virus Type I (HTLV-I) Retropepsin , Pages 213-217 Chapter 50 - Bovine Leukemia Virus Retropepsin , Pages 218-220 Chapter 51 - Mason–Pfizer Monkey Virus Retropepsin , Pages 221-223 Chapter 52 - Mouse Mammary Tumor Virus Retropepsin , Pages 223-226 Chapter 53 - Moloney Murine Leukemia Virus Retropepsin , Pages 226-230 Chapter 54 - Feline Immunodeficiency Virus Retropepsin , Pages 230-234 Chapter 55 - Human Retrovirus K10 Retropepsin , Pages 234-237 Chapter 56 - Miscellaneous Viral Retropepsins , Pages 237-240 Chapter 57 - Skin Aspartic Protease , Pages 241-245 Chapter 58 - Spumapepsins , Pages 245-248 Chapter 59 - Fungal, Plant and Animal Retrotransposon Elements , Pages 248-253 Chapter 60 - Cauliflower Mosaic Virus Proteinase , Pages 253-255 Chapter 61 - Ddi1 and Related Proteins , Pages 255-258 Chapter 62 - Signal Peptidase II , Pages 258-261 Chapter 63 - Type IV Prepilin Peptidase , Pages 261-265 Chapter 64 - Preflagellin Peptidase , Pages 266-273 Chapter 65 - Presenilin-1 , Pages 273-278 Chapter 66 - Presenilin-2 , Pages 278-281 Chapter 67 - Signal Peptide Peptidase , Pages 281-284 Chapter 68 - Omptin , Pages 284-289 Chapter 69 - Plasminogen Activator of Yersinia pestis , Pages 289-293 Chapter 70 - Hydrogenase Maturation Endopeptidase , Pages 294-296 Chapter 71 - Endopeptidase GPR , Pages 296-298 Chapter 72 - Thermopsin , Pages 299-301 Chapter 73 - Scytalidoglutamic Peptidase , Pages 301-307 Chapter 74 - Aspergilloglutamic Peptidase , Pages 307-310 Chapter 75 - Nodavirus Peptide Lyase , Pages 310-314 Chapter 76 - Self-Splicing Proteins , Pages 315-321 Chapter 77 - Introduction: Metallopeptidases and Their Clans , Pages 325-370 Chapter 78 - Catalytic Mechanisms for Metallopeptidases , Pages 370-396 Chapter 79 - Aminopeptidase N , Pages 397-403 Chapter 80 - Aminopeptidase Ey , Pages 403-405 Chapter 81 - Insect Aminopeptidase N , Pages 405-409 Chapter 82 - Glutamyl Aminopeptidase , Pages 410-414 Chapter 83 - Pyroglutamyl-Peptidase II , Pages 414-419 Chapter 84 - Cystinyl Aminopeptidase/Oxytocinase , Pages 419-425 Chapter 85 - Aminopeptidase PILS , Pages 425-430 Chapter 86 - Cytosol Alanyl Aminopeptidase , Pages 431-434 Chapter 87 - Endoplasmic Reticulum Aminopeptidase 2 , Pages 434-438 Chapter 88 - Aminopeptidase O , Pages 438-442 Chapter 89 - Aminopeptidase Q/Laeverin , Pages 442-444 Chapter 90 - PfA-M1 Aminopeptidase ( Plasmodium falciparum ) , Pages 445-448 Chapter 91 - Yeast Aminopeptidases Ape2, Aap1′ and Yin7 , Pages 448-450 Chapter 92 - Lysyl Aminopeptidase (Bacteria) , Pages 451-454 Chapter 93 - Aminopeptidase N ( Streptomyces lividans ) , Pages 455-456 Chapter 94 - Alanyl Aminopeptidase (Bacterial-type) , Pages 456-462 Chapter 95 - The Cold-Active M1 Aminopeptidase from the Arctic Bacterium Colwellia psychrerythraea , Pages 463-467 Chapter 96 - Leukotriene A 4 Hydrolase , Pages 468-472 Chapter 97 - Aminopeptidase B , Pages 473-479 Chapter 98 - Peptidyl-Dipeptidase A/Angiotensin I-Converting Enzyme , Pages 480-494 Chapter 99 - Peptidyl-Dipeptidase A (Invertebrate) , Pages 494-498 Chapter 100 - Angiotensin-Converting Enzyme-2 , Pages 499-504 Chapter 101 - Thimet Oligopeptidase , Pages 504-509 Chapter 102 - Neurolysin , Pages 509-513 Chapter 103 - Saccharolysin , Pages 513-515 Chapter 104 - Tropolysin , Pages 515-518 Chapter 105 - Oligopeptidase A , Pages 518-520 Chapter 106 - Peptidyl-Dipeptidase Dcp , Pages 520-524 Chapter 107 - Mitochondrial Intermediate Peptidase , Pages 524-529 Chapter 108 - Oligopeptidase F (Oligopeptidase B) , Pages 529-534 Chapter 109 - Oligopeptidase MepB , Pages 534-536 Chapter 110 - Pz-Peptidase A , Pages 536-539 Chapter 111 - Thermolysin and Related Bacillus Metallopeptidases , Pages 540-553 Chapter 112 - Stearolysin , Pages 554-560 Chapter 113 - Lambda Toxin ( Clostridium perfringens ) , Pages 561-563 Chapter 114 - Aureolysin , Pages 563-569 Chapter 115 - Listeria Metalloprotease Mpl , Pages 569-572 Chapter 116 - Griselysin , Pages 572-574 Chapter 117 - Coccolysin , Pages 574-577 Chapter 118 - PA Peptidase ( Aeromonas ) , Pages 577-579 Chapter 119 - Vibriolysin , Pages 579-582 Chapter 120 - Pseudolysin , Pages 582-592 Chapter 121 - Legionella Metalloendopeptidase , Pages 592-594 Chapter 122 - Vimelysin , Pages 595-597 Chapter 123 - Protealysin , Pages 597-602 Chapter 124 - Mycolysin , Pages 603-604 Chapter 125 - Vibrio Collagenase , Pages 604-606 Chapter 126 - Clostridium Collagenases , Pages 607-611 Chapter 127 - Neprilysin , Pages 612-619 Chapter 128 - Neprilysin-2 , Pages 620-624 Chapter 129 - Endothelin - Converting Enzyme-1 (ECE-1) , Pages 624-631 Chapter 130 - Endothelin-Converting Enzyme-2 , Pages 632-635 Chapter 131 - Endothelin-Converting Enzyme-Like Peptidase 1 , Pages 636-637 Chapter 132 - PHEX Endopeptidase , Pages 638-641 Chapter 133 - Kell Blood-Group Protein , Pages 642-644 Chapter 134 - Nep2 Peptidase (Insect) , Pages 644-646 Chapter 135 - Hookworm MEP-1 Metalloproteases , Pages 647-649 Chapter 136 - Oligopeptidase O , Pages 650-653 Chapter 137 - Neprilysin Homolog of streptococci , Pages 653-655 Chapter 138 - Tentoxilysin , Pages 655-660 Chapter 139 - Bontoxilysins , Pages 660-665 Chapter 140 - Hyicolysin , Pages 665-668 Chapter 141 - Ste24 Protease , Pages 668-676 Chapter 142 - Mammalian Farnesylated Protein-Converting Enzyme 1 , Pages 677-682 Chapter 143 - HtpX Peptidase , Pages 683-685 Chapter 144 - FtsH Protease , Pages 685-692 Chapter 145 - Mitochondrial M-Protease , Pages 692-695 Chapter 146 - The i -AAA Protease , Pages 696-701 Chapter 147 - Plant Mitochondrial FtsH Peptidases , Pages 702-705 Chapter 148 - Paraplegin , Pages 706-709 Chapter 149 - FtsH Homolog in Chloroplasts , Pages 710-713 Chapter 150 - Baculovirus Enhancin , Pages 713-716 Chapter 151 - Glycyl Aminopeptidase ( Sphingomonas ) , Pages 716-717 Chapter 152 - Matrix Metallopeptidase-1/Interstitial Collagenase , Pages 718-725 Chapter 153 - Neutrophil Collagenase , Pages 725-734 Chapter 154 - Matrix Metallopeptidase-13/Collagenase 3 , Pages 734-744 Chapter 155 - Matrix Metallopeptidase-18/Collagenase 4 , Pages 744-747 Chapter 156 - Matrix Metallopeptidase-2/Gelatinase A , Pages 747-753 Chapter 157 - Matrix Metallopeptidase 9/Gelatinase B , Pages 754-763 Chapter 158 - Matrix Metalloproteinase 3/Stromelysin 1 , Pages 763-774 Chapter 159 - Matrix Metallopeptidase-10/Stromelysin 2 , Pages 774-778 Chapter 160 - Matrix Metalloproteinase-11/Stromelysin 3 , Pages 779-786 Chapter 161 - Matrix Metallopeptidase-7/Matrilysin , Pages 786-795 Chapter 162 - Matrix Metalloproteinase-26/Matrilysin 2 ( Homo sapiens ) , Pages 795-800 Chapter 163 - Matrix Metallopeptidase-12/Macrophage Elastase , Pages 800-804 Chapter 164 - Membrane-type Matrix Metalloproteinase 1 , Pages 804-814 Chapter 165 - Membrane-type Matrix Metalloproteinase 2 , Pages 815-817 Chapter 166 - Membrane-type 3-Matrix Metalloproteinase (MMP16) , Pages 817-822 Chapter 167 - Membrane-type Matrix Metalloproteinase 4 , Pages 823-826 Chapter 168 - Membrane-type Matrix Metalloproteinase 5 , Pages 826-828 Chapter 169 - Membrane-type Matrix Metalloproteinase 6 , Pages 828-830 Chapter 170 - Matrix Metallopeptidase-19 , Pages 830-835 Chapter 171 - Matrix Metalloproteinase-20/Enamelysin , Pages 835-840 Chapter 172 - Matrix Metalloproteinase 21 , Pages 840-841 Chapter 173 - Chicken Matrix Metalloproteinase 22 , Pages 842-843 Chapter 174 - Matrix Metalloproteinase 23 , Pages 843-845 Chapter 175 - Matrix Metallopeptidase-28/Epilysin , Pages 845-850 Chapter 176 - Dm1 and Dm2 Matrix Metallopeptidases , Pages 850-854 Chapter 177 - Plant Matrixins , Pages 854-856 Chapter 178 - Hydra Matrix Metalloproteinase (HMMP) , Pages 857-859 Chapter 179 - Envelysin , Pages 859-863 Chapter 180 - Serralysin and Related Enzymes , Pages 864-867 Chapter 181 - Aeruginolysin , Pages 867-872 Chapter 182 - Mirabilysin , Pages 872-875 Chapter 183 - Epralysin , Pages 875-877 Chapter 184 - PrtA Peptidases , Pages 877-882 Chapter 185 - Karilysin , Pages 883-886 Chapter 186 - Fragilysin , Pages 887-891 Chapter 187 - Gametolysin , Pages 891-895 Chapter 188 - Astacin , Pages 895-900 Chapter 189 - Meprin A , Pages 900-910 Chapter 190 - Meprin B , Pages 910-916 Chapter 191 - Procollagen C-Endopeptidase , Pages 916-932 Chapter 192 - Tolloid ( Drosophila ) , Pages 932-936 Chapter 193 - Mammalian Tolloid-like Peptidases , Pages 936-942 Chapter 194 - Choriolysin L , Pages 942-945 Chapter 195 - Choriolysin H , Pages 945-949 Chapter 196 - Myosinase , Pages 949-950 Chapter 197 - Hydra Metalloproteinase 1 (HMP1) , Pages 951-954 Chapter 198 - Flavastacin , Pages 954-955 Chapter 199 - Other Astacin Homologs , Pages 956-961 Chapter 200 - Introduction to the Reprolysins , Pages 961-963 Chapter 201 - Brevilysin H6 , Pages 964-965 Chapter 202 - Gloydius halys Venom Metalloproteinases , Pages 965-967 Chapter 203 - Acutolysin , Pages 968-969 Chapter 204 - Bilitoxin , Pages 970-971 Chapter 205 - Fibrolase , Pages 972-976 Chapter 206 - Venom Metalloproteases of Agkistrodon contortrix laticinctus , Pages 977-980 Chapter 207 - Leucolysin , Pages 980-981 Chapter 208 - Bothrops asper Hemorrhagic Proteinases , Pages 981-984 Chapter 209 - Bothrops asper Metalloproteinase BaP1 , Pages 984-987 Chapter 210 - Jararhagin , Pages 987-990 Chapter 211 - Bothrolysin , Pages 991-992 Chapter 212 - Bothropasin , Pages 992-995 Chapter 213 - Jararafibrases II–IV of Bothrops jararaca , Pages 995-997 Chapter 214 - Hemorrhagic Factor 3 (HF3) , Pages 997-999 Chapter 215 - Basic Endopeptidases of Bothrops moojeni Venom , Pages 1000-1001 Chapter 216 - BmooMPα-I ( Bothrops moojeni ) , Pages 1001-1005 Chapter 217 - Neuwiedase ( Bothrops neuwiedi ) , Pages 1005-1012 Chapter 218 - Leucuraolysin-A , Pages 1013-1016 Chapter 219 - Mucrolysin , Pages 1016-1018 Chapter 220 - Kistomin , Pages 1018-1021 Chapter 221 - Adamalysin , Pages 1021-1024 Chapter 222 - Atrolysin A , Pages 1024-1027 Chapter 223 - Atrolysin B , Pages 1027-1028 Chapter 224 - Atrolysin C , Pages 1029-1031 Chapter 225 - Atrolysin E , Pages 1031-1033 Chapter 226 - Atrolysin F , Pages 1034-1035 Chapter 227 - Atroxase , Pages 1035-1036 Chapter 228 - Vascular Apoptosis-Inducing Protein 1 , Pages 1036-1038 Chapter 229 - Basilysin , Pages 1038-1041 Chapter 230 - Horrilysin , Pages 1041-1042 Chapter 231 - Ruberlysin , Pages 1043-1044 Chapter 232 - Trimerelysin I , Pages 1044-1046 Chapter 233 - Trimerelysin II , Pages 1046-1047 Chapter 234 - Triflamp ( Trimeresurus flavoviridis ) , Pages 1048-1051 Chapter 235 - Russellysin , Pages 1051-1053 Chapter 236 - Lebetase , Pages 1054-1057 Chapter 237 - Bitis arietans Hemorrhagic Proteinases , Pages 1057-1059 Chapter 238 - Carinactivase , Pages 1060-1061 Chapter 239 - Multactivase , Pages 1062-1064 Chapter 240 - Ecarin , Pages 1064-1067 Chapter 241 - Mutalysins , Pages 1067-1070 Chapter 242 - Najalysin , Pages 1071-1073 Chapter 243 - Mocarhagin , Pages 1073-1076 Chapter 244 - Ophiolysin , Pages 1076-1078 Chapter 245 - Philodryas Venom Metalloproteinases , Pages 1078-1079 Chapter 246 - Antarease , Pages 1079-1081 Chapter 247 - Loxosceles Astacin-Like Proteases (LALPs) , Pages 1081-1086 Chapter 248 - ADAM Metalloproteinases , Pages 1086-1094 Chapter 249 - ADAM8/MS2/CD156a , Pages 1094-1101 Chapter 250 - ADAM9 , Pages 1101-1107 Chapter 251 - ADAM10, Myelin-associated Metalloendopeptidase , Pages 1108-1114 Chapter 252 - ADAM12 , Pages 1114-1122 Chapter 253 - ADAM15 Peptidase , Pages 1122-1125 Chapter 254 - ADAM17, Tumor Necrosis Factor α-Convertase , Pages 1126-1130 Chapter 255 - ADAM19/Meltrin Beta , Pages 1131-1135 Chapter 256 - ADAM28 , Pages 1136-1139 Chapter 257 - ADAM33 , Pages 1140-1146 Chapter 258 - Kuzbanian ( Drosophila ) , Pages 1146-1149 Chapter 259 - The ADAMTS Endopeptidases , Pages 1149-1155 Chapter 260 - ADAMTS1 , Pages 1156-1161 Chapter 261 - Procollagen N-Endopeptidases , Pages 1161-1166 Chapter 262 - ADAMTS4 , Pages 1166-1173 Chapter 263 - ADAMTS5 , Pages 1174-1180 Chapter 264 - ADAMTS7 , Pages 1180-1186 Chapter 265 - ADAMTS9 , Pages 1186-1191 Chapter 266 - ADAMTS10 , Pages 1191-1194 Chapter 267 - ADAMTS12 , Pages 1194-1198 Chapter 268 - ADAMTS13: von Willebrand Factor-Cleaving Protease , Pages 1199-1206 Chapter 269 - Cytophagalysin , Pages 1207-1208 Chapter 270 - Ulilysin ( Methanosarcina acetivorans ) , Pages 1208-1211 Chapter 271 - Pappalysin-1 (Pregnancy-Associated Plasma Protein-A) , Pages 1212-1217 Chapter 272 - Immune Inhibitor A , Pages 1217-1219 Chapter 273 - The Protease of Vibrio cholerae (PrtV) , Pages 1219-1225 Chapter 274 - The IgA Protease of Clostridium ramosum , Pages 1225-1228 Chapter 275 - Snapalysin , Pages 1228-1230 Chapter 276 - Leishmanolysin , Pages 1231-1237 Chapter 277 - BlaR1 and MecR1 Gene Products of Staphylococcus aureus , Pages 1237-1242 Chapter 278 - IgA-Specific Metalloendopeptidase , Pages 1243-1248 Chapter 279 - Carboxypeptidase Taq , Pages 1249-1253 Chapter 280 - Carboxypeptidase Taq -Like Peptidases from Trypanosomatids , Pages 1253-1257 Chapter 281 - Anthrax Lethal Factor , Pages 1257-1261 Chapter 282 - Penicillolysin , Pages 1261-1263 Chapter 283 - Deuterolysin , Pages 1264-1266 Chapter 284 - Peptidyl-Lys Metalloendopeptidase , Pages 1266-1270 Chapter 285 - Fungalysin , Pages 1270-1272 Chapter 286 - StcE Peptidase and the StcE-Like Metalloendopeptidases , Pages 1272-1280 Chapter 287 - Peptidyl-Asp Metalloendopeptidase , Pages 1281-1285 Chapter 288 - Dipeptidyl-Peptidase III , Pages 1285-1289 Chapter 289 - Carboxypeptidase A , Pages 1289-1301 Chapter 290 - Carboxypeptidase A2 , Pages 1301-1306 Chapter 291 - Carboxypeptidase A4 , Pages 1307-1310 Chapter 292 - Carboxypeptidase A3 , Pages 1310-1315 Chapter 293 - Carboxypeptidase A5 , Pages 1315-1317 Chapter 294 - Carboxypeptidase A6 , Pages 1318-1321 Chapter 295 - Carboxypeptidase U , Pages 1321-1324 Chapter 296 - Carboxypeptidase B , Pages 1324-1329 Chapter 297 - Carboxypeptidase MeCPA , Pages 1329-1331 Chapter 298 - Carboxypeptidase T , Pages 1331-1334 Chapter 299 - Lysine Carboxypeptidase/Carboxypeptidase N , Pages 1334-1342 Chapter 300 - Carboxypeptidase E , Pages 1342-1345 Chapter 301 - Carboxypeptidase Z , Pages 1346-1347 Chapter 302 - Adipocyte Enhancer Binding Protein 1 and Aortic Carboxypeptidase-Like Protein , Pages 1348-1353 Chapter 303 - Metallocarboxypeptidase D , Pages 1353-1357 Chapter 304 - Carboxypeptidase M , Pages 1357-1366 Chapter 305 - Insect Carboxypeptidases , Pages 1366-1370 Chapter 306 - Insect Gut Carboxypeptidase 3 , Pages 1370-1375 Chapter 307 - Metallocarboxypeptidase G ( Porphyromonas gingivalis ) , Pages 1375-1380 Chapter 308 - γ- d -Glutamyl-( l )-meso-diaminopimelate Peptidase I , Pages 1381-1383 Chapter 309 - Murein Peptide Amidase MpaA , Pages 1383-1385 Chapter 310 - Tubulinyl-Tyr Carboxypeptidase , Pages 1385-1389 Chapter 311 - Zinc d -Ala- d -Ala Carboxypeptidase , Pages 1389-1392 Chapter 312 - d -Ala- d -Ala Carboxypeptidase VanY , Pages 1393-1395 Chapter 313 - VanX d -, d -Dipeptidase , Pages 1395-1401 Chapter 314 - N -Acetylmuramoyl- l -alanine Amidase , Pages 1401-1407 Chapter 315 - l -Alanoyl- d -Glutamate Peptidase (Bacteriophage T5) , Pages 1407-1410 Chapter 316 - Murein Endopeptidase MepA , Pages 1410-1412 Chapter 317 - Pitrilysin , Pages 1412-1414 Chapter 318 - Insulysin , Pages 1415-1420 Chapter 319 - Nardilysin , Pages 1421-1426 Chapter 320 - Mitochondrial and Chloroplastic Targeting Peptides Peptidase, PreP , Pages 1426-1430 Chapter 321 - The Yeast M16A Peptidases Axl1p and Ste23p , Pages 1430-1434 Chapter 322 - Mitochondrial Processing Peptidase , Pages 1435-1442 Chapter 323 - Chloroplast Stromal Processing Peptidase , Pages 1442-1447 Chapter 324 - Plinsulysin , Pages 1447-1450 Chapter 325 - YMXG Peptidase , Pages 1450-1457 Chapter 326 - Eupitrilysin , Pages 1457-1459 Chapter 327 - Falcilysin , Pages 1459-1461 Chapter 328 - Vaccinia Virus Metalloproteinase , Pages 1462-1464 Chapter 329 - Leucyl Aminopeptidase (Animal) , Pages 1465-1470 Chapter 330 - Leucyl Aminopeptidase (Plant) , Pages 1471-1476 Chapter 331 - Leucyl Aminopeptidase yspII (Yeast) , Pages 1476-1480 Chapter 332 - Leucyl Aminopeptidase of Plasmodium falciparum , Pages 1481-1484 Chapter 333 - Leucyl Aminopeptidase PepA , Pages 1484-1492 Chapter 334 - Peptidase B ( Escherichia coli ) , Pages 1492-1494 Chapter 335 - Methionyl Aminopeptidase Type 1 , Pages 1495-1500 Chapter 336 - Methionyl Aminopeptidase Type 2 , Pages 1501-1506 Chapter 337 - Xaa-Pro Dipeptidase (Bacteria) , Pages 1506-1507 Chapter 338 - Xaa-Pro Dipeptidase (Eukaryotes) , Pages 1507-1514 Chapter 339 - Xaa-Pro Dipeptidase (Archaea) , Pages 1514-1519 Chapter 340 - Xaa-Pro Aminopeptidase (Prokaryote) , Pages 1519-1523 Chapter 341 - Xaa-Pro Aminopeptidase ( Lactococcus ) , Pages 1524-1525 Chapter 342 - Aminopeptidase P1 , Pages 1525-1528 Chapter 343 - Aminopeptidase P2 , Pages 1528-1532 Chapter 344 - Mitochondrial Intermediate Cleaving Peptidase Icp55 , Pages 1533-1536 Chapter 345 - S2P Protease , Pages 1536-1541 Chapter 346 - Sporulation Factor SpoIVFB , Pages 1541-1545 Chapter 347 - RseP Peptidase , Pages 1545-1550 Chapter 348 - β-Lytic Metalloendopeptidase , Pages 1550-1553 Chapter 349 - Staphylolysin , Pages 1553-1558 Chapter 350 - Lysostaphin , Pages 1558-1560 Chapter 351 - Poh1 Peptidase , Pages 1560-1566 Chapter 352 - Mec + Peptidase ( Mycobacterium tuberculosis ) , Pages 1567-1570 Chapter 353 - Aspartyl Aminopeptidase , Pages 1570-1573 Chapter 354 - Aminopeptidase I , Pages 1574-1576 Chapter 355 - Glutamate Carboxypeptidase , Pages 1576-1581 Chapter 356 - Peptidase T , Pages 1582-1586 Chapter 357 - Peptidase V , Pages 1586-1592 Chapter 358 - Carnosine Dipeptidase I , Pages 1592-1596 Chapter 359 - Carnosine Dipeptidase II , Pages 1596-1600 Chapter 360 - Gly-Xaa Carboxypeptidase , Pages 1600-1601 Chapter 361 - Xaa-His Dipeptidase (Bacteria) , Pages 1601-1603 Chapter 362 - Xaa-Methyl-His Dipeptidase , Pages 1603-1608 Chapter 363 - Carboxypeptidase Ss1 , Pages 1608-1611 Chapter 364 - Aminopeptidase Y , Pages 1611-1613 Chapter 365 - Dug1 Peptidase , Pages 1613-1617 Chapter 366 - Streptomyces griseus Aminopeptidase , Pages 1617-1620 Chapter 367 - Glutamate Carboxypeptidase II , Pages 1620-1627 Chapter 368 - Vibrio Aminopeptidase , Pages 1627-1630 Chapter 369 - Glutamyl Aminopeptidase ( Lactococcus ) , Pages 1631-1635 Chapter 370 - Bacillus Aminopeptidase I , Pages 1635-1637 Chapter 371 - PhTET1 Aminopeptidase , Pages 1638-1645 Chapter 372 - PhTET2 Aminopeptidase , Pages 1645-1650 Chapte Extensively revised and updated, the new edition of the highly regarded Handbook of Proteolytic Enzymes is an essential reference for biochemists, biotechnologists and molecular biologists. Edited by world-renowned experts in the field, this comprehensive work provides detailed information on all known proteolytic enzymes to date. This two-volume set unveils new developments on proteolytic enzymes which are being investigatedin pharmaceutical research for such diseases as HIV, Hepatitis C, and the common cold.

Volume I covers aspartic and metallo petidases while Volume II examines peptidases of cysteine, serine, threonine and unknown catalytic type. A CD-ROM accompanies the book containing fully searchable text, specialised scissile bond searches, 3-D color structures and much more.

* The only comprehensive book on proteolytic enzymes
* Includes 671 chapters, each written by experts in their field, on proteolytic enzymes from all groups of living organisms and the viruses, including those that are currently major targets of pharmaceutical research
* Accompanying CD-ROM provides fully searchable text, 2D structures of peptidases in color and links directly to PubMed and MEROPS databases
*Each chapter describes in detail the enzyme name, its history, activity and specificity, structural chemistry, preparation, biological aspects and distinguishing features
*Over 1000 peptidases included The third edition of the Handbook of Proteolytic Enzymes is a comprehensive reference work for the enzymes that cleave proteins and peptides, written by acknowledged experts in the field and containing over 850 chapters. Each chapter is organized into sections describing the name and history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features for a specific peptidase. There are also introductory chapters on peptidase classification and mechanisms and a comprehensive index. For the first time, the Handbook is also available online via Elsevier's ScienceDirect platform as well as a three-volume book. The online version has enhanced options, including online multimedia, cross-referencing capabilities, integrated online delivery and closer integration with the online MEROPS database of peptidases and their inhibitors. This reference work is a must-have for biochemists, biotechnologists, molecular biologists and students in these disciplines, and will be of great interest to pharmaceutical and biotechnology companies. Contains over 830 chapters Covers new research in therapeutics and drug trials Supplies content written by experts in the field The third edition of the Handbook of Proteolytic Enzymes is a fully revised and updated major reference work in Elsevier's canon. For the first time the Handbook will be available as an online via Elsevier's ScienceDirect platform as well as a three-volume book. The online version will have the enhanced options including online multimedia, cross-referencing capabilities, integrated online delivery and closer integration with the online MEROPS database of peptidases and their inhibitors. This reference work is intended for university libraries, researchers and students, and will be of great interest to the pharmaceutical and biotechnology companies. The new edition will feature articles on approximately 1000 different proteolytic enzymes written by acknowledged experts in the field. Each article will be a full but concise summary, including details of activity and specificity, structural chemistry, preparation and biological aspects. There are also introductory chapters on peptidase classification and mechanisms and a comprehensive index. Contains over 830 chapters. Covers new research in therapeutics and drug trialsSupplies content written by experts in the field "The third edition of the Handbook of Proteolytic Enzymes is a fully revised and updated major reference work in Elsevier's canon. For the first time the Handbook will be available as an online via Elsevier's ScienceDirect platform as well as a three-volume book. The online version will have the enhanced options including online multimedia, cross-referencing capabilities, integrated online delivery and closer integration with the online MEROPS database of peptidases and their inhibitors. This reference work is intended for university libraries, researchers and students, and will be of great interest to the pharmaceutical and biotechnology companies."--description from Elsevier.com