Handbook of Neurochemistry and Molecular Neurobiology: Neuroimmunology (Springer Reference)

This volume contains data on multiple immunomodulators, many of which are also the products of hypothalamic brain cell neurosecretion. Interleukins (IL-1a, IL-1ß, IL-2, IL-4, IL-6, TNFa), immunophylin and ubiquitin as well as proline rich peptides, comprised of 10-15 amino acids are being produced in N. Supraopticus and N. Paraventricularis and then secreted into neurohypophysis. Along the neurosecretion of the mentioned cytokines, there are other immunomodulators, the primary structure of which had been completely deciphered such as: Immunophyllins, intracellular receptors of immunosuppressors FK506, cyclosporine A., rapamicin. They are peptidyl-prolyl-cis-trans-isomerases. There are novel immunological hypothalamic factors such as ubiquitin, macrophage migration inhibitory factor (MIF), as well as Thymosin ß 4 (1-39). This data allowed us to propose the concept of neuroendocrine immune system of the brain. Neuroimmunology is one of the most rapidly developing branches of Neurobiology, and this volume contains chapters that focus on a huge range of topics including the relationship between neuroimmunology and the pathogenesis of different nervous diseases. Front Matter....Pages i-x Back Matter....Pages 3-17 ....Pages 19-35