Handbook of In Vivo Chemistry in Mice : From Lab to Living System

Provides timely, comprehensive coverage of in vivo chemical reactions within live animals This handbook summarizes the interdisciplinary expertise of both chemists and biologists performing in vivo chemical reactions within live animals. By comparing and contrasting currently available chemical and biological techniques, it serves not just as a collection of the pioneering work done in animal-based studies, but also as a technical guide to help readers decide which tools are suitable and best for their experimental needs. The Handbook of In Vivo Chemistry in Mice: From Lab to Living System introduces readers to general information about live animal experiments and detection methods commonly used for these animal models. It focuses on chemistry-based techniques to develop selective in vivo targeting methodologies, as well as strategies for in vivo chemistry and drug release. Topics include: currently available mouse models; biocompatible fluorophores; radionuclides for radiodiagnosis/radiotherapy; live animal imaging techniques such as positron emission tomography (PET) imaging; magnetic resonance imaging (MRI); ultrasound imaging; hybrid imaging; biocompatible chemical reactions; ligand-directed nucleophilic substitution chemistry; biorthogonal prodrug release strategies; and various selective targeting strategies for live animals. -Completely covers current techniques of in vivo chemistry performed in live animals -Describes general information about commonly used live animal experiments and detection methods -Focuses on chemistry-based techniques to develop selective in vivo targeting methodologies, as well as strategies for in vivo chemistry and drug release -Places emphasis on material properties required for the development of appropriate compounds to be used for imaging and therapeutic purposes in preclinical applications Handbook of In Vivo Chemistry in Mice: From Lab to Living System will be of great interest to pharmaceutical chemists, life scientists, and organic chemists. It will also appeal to those working in the pharmaceutical and biotechnology industries. Of Currently Available Mouse Models / Ami Ito, Namiko Ito, Kimie Niimi, Takashi Arai, Eiki Takahashi -- General Notes of Chemical Administration to Live Animals / Ami Ito, Namiko Ito, Takashi Arai, Eiki Takahashi, Kimie Niimi -- Optical-Based Detection in Live Animals / Mikako Ogawa, Hideo Takakura -- Ultrasound Imaging in Live Animals / Francesco Faita -- Positron Emission Tomography (PET) Imaging in Live Animals / Xiaowei Ma, Zhen Cheng -- Single-Photon Emission Computed Tomographic Imaging in Live Animals / Yusuke Yagi, Hidekazu Kawashima, Kenji Arimitsu, Koki Hasegawa, Hiroyuki Kimura -- Radiotherapeutic Applications / Koki Hasegawa, Hidekazu Kawashima, Yusuke Yagi, Hiroyuki Kimura -- Metabolic Glycan Engineering in Live Animals: Using Bio-orthogonal Chemistry to Alter Cell Surface Glycans / Danielle H Dube, Daniel A Williams -- In Vivo Bioconjugation Using Bio-orthogonal Chemistry / Maksim Royzen, Nathan Yee, Jose M Mejia Oneto -- In Vivo Targeting of Endogenous Proteins with Reactive Small Molecules / Naoya Shindo, Akio Ojida -- In Vivo Metal Catalysis in Living Biological Systems / Kenward Vong, Katsunori Tanaka -- Chemical Catalyst-Mediated Selective Photo-oxygenation of Pathogenic Amyloids / Youhei Sohma, Motomu Kanai -- Nanomedicine Therapies / Patrícia Figueiredo, Flavia Fontana, Hélder A Santos -- Photoactivatable Targeting Methods / Xiangzhao Ai, Ming Hu, Bengang Xing -- Photoactivatable Drug Release Methods from Liposomes / Hailey I Kilian, Dyego Miranda, Jonathan F Lovell -- Peptide Targeting Methods / Ruei-Min Lu, Chien-Hsun Wu, Ajay V Patil, Han-Chung Wu -- Glycan-Mediated Targeting Methods / Kenward Vong, Katsunori Tanaka, Koichi Fukase