Handbook of hormones : comparative endocrinology for basic and clinical research. Volume 1 and Volume 2

__Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research, Second Edition__ presents a catalog of fundamental information on the structure and function of hormones from basic biology to clinical use, offering a rapid way to obtain specific facts about the chemical and molecular characteristics of hormones, their receptors, signaling pathways, and the biological activities they regulate. The book's stellar editorial board, affiliated with the Japan Society for Comparative Endocrinology, brings together authors that present a compelling structure of each hormone with a consistent presentation that provides a primer surrounding the plethora of hormones that now exist. Comparative endocrinology continues to rapidly expand and new information about hormones is being produced almost daily, making it important to stay up-to-date. Hormone, paracrine, and autocrine factors have been identified as key players in a range of different systems, including immune, musculoskeletal and cardiovascular. Frontiers between disciplines are being blurred and many scientists in fields other than endocrinology are interested in hormones. Scientists now have the unprecedented opportunity to look from invertebrates to vertebrate and identify novel regulatory factors and understand their function and how they determine an organism’s physiology and survival. 9780128206508_WEB01 Front Cover Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research Copyright List of editors Volume 1 Contents Volume 2 Contents Contributors Preface to first edition Preface to the second edition Abbreviations Chapter 1: Evolution and diversity of animals Introduction Metazoa Protostomia Deuterostomia Evolution of hormones and their receptors References Part I: Peptides and proteins in vertebrates Chapter 2: Molecular evolution of peptide and protein hormones in vertebrates Introduction Sequence homology and protein families Orthology Synteny Omics solutions References Section I.1: Neuropeptides Chapter 3: RFamide peptide family History Structure Structural features Molecular evolution of family members Receptors Structure and subtypes Signal transduction pathway Biological functions Target cells/tissues and functions Supplemental information available on companion website References Subchapter 3A: Gonadotropin-inhibitory hormone Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 3B: Kisspeptin Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 3C: PQRFamide peptide Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 3D: Pyroglutamylated RFamide peptide Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 3E: Prolactin-releasing peptide Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Chapter 4: Corticotropin-releasing hormone family History Structure Structural features Molecular evolution of family members Receptors Structure and subtypes Signal transduction pathway Biological functions Target cells/tissues and functions Supplemental information available on companion website References Subchapter 4A: Corticotropin-releasing hormone Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 4B: Urotensin I Discovery Structure Synthesis and release Receptors Biological functions Supplemental information available on companion website References Subchapter 4C: Urocortins Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 4D: Sauvagine Discovery Structure Synthesis and release Receptors Biological functions References Chapter 5: Gonadotropin-releasing hormone Discovery Structure Structural features Primary structure Properties Synthesis and release Gene, mRNA, and precursor Distribution of mRNA Tissue content Plasma concentration Regulation of synthesis and release Receptors Structure and subtype Signal transduction pathway Agonist Antagonist Biological functions Target cells/tissues and functions (Table 5.1) Pathophysiological implications Clinical implications Use for diagnosis and treatment Supplemental information available on companion website References Chapter 6: Thyrotropin-releasing hormone Discovery Structure Structural features Primary structure Properties Synthesis and release Gene, mRNA, and precursor Tissue distribution of mRNA Tissue content Plasma concentration Regulation of synthesis and release Receptors Structure and subtype Signal transduction pathway Biological functions Target cells/tissues and functions (Table 6.2) Pathophysiological implications Clinical implications Use for diagnosis and treatment Supplemental information available on companion website References Chapter 7: Somatostatin Discovery Structure Structural features Primary structure Properties Synthesis and release Gene, mRNA, and precursor Distribution of mRNA Tissue content Plasma concentration Regulation of synthesis and release Receptors Structure and subtype, signal transduction pathway, agonist, and antagonist Biological functions Target cells/tissues and functions Phenotype in gene-modified animals Pathophysiological implications Clinical implications Use for diagnosis and treatment Supplemental information available on companion website References Chapter 8: Neurohypophysial hormone family History Structure Structural features Molecular evolution of family members Receptors Structure and subtypes Signal transduction pathway Biological functions Target cells/tissues and functions References Subchapter 8A: Vasopressin Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 8B: Vasotocin Discovery Structure Synthesis and release Receptors Biological functions Supplemental information available on companion website References Subchapter 8C: Oxytocin Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 8D: Nonmammalian OT-family peptides Discovery Structure Synthesis and release Receptors Biological functions Supplemental information available on companion website References Chapter 9: Opioid peptide family History Structure Structural features Molecular evolution of family members Receptors Structure and subtypes Signal transduction pathway Heteromer-directed signal specificity Desensitization and signaling by arrestin Biological functions Target cells/tissues and functions References Subchapter 9A: Enkephalin Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 9B: Dynorphin/a-neo-endorphin Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications References Subchapter 9C: Nociceptin/orphanin FQ Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 9D: Endomorphin Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications References Subchapter 9E: Dermorphin Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications References Chapter 10: Agouti family History Structure Structural features Molecular evolution of family members Receptors Biological functions Target cells/tissues and functions Supplemental information available on companion website References Subchapter 10A: Agouti-signaling protein Discovery Structure Synthesis and release Receptors Biological functions Supplemental information available on companion website References Subchapter 10B: Agouti-related protein Discovery Structure Synthesis and release Receptors Biological functions Supplemental information available on companion website References Chapter 11: Tachykinin family History Structure Structural features and primary structure Properties Synthesis and release Gene, mRNA, and precursor Tissue distribution of mRNA Receptors Structure and subtype Signal transduction pathway Biological functions Target cells/tissues and functions Supplemental information available on companion website References Subchapter 11A: Substance P/neurokinin A Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 11B: Neurokinin B Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Chapter 12: Appetite-regulating peptides History Structures and receptors Biological functions References Subchapter 12A: Melanin-concentrating hormone Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 12B: Orexin Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 12C: Cocaine- and amphetamine-regulated transcript Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Chapter 13: Urotensin II Discovery Structure Primary structural features Properties Synthesis and release Gene, mRNA, and precursor Tissue distribution of mRNA Tissue content Plasma concentration Regulation of synthesis and release Receptors Structure and subtype Signal transduction pathway Biological functions Target cells/tissues and functions Phenotype of gene-modified animals Pathophysiological implications Clinical implications Supplemental information available on companion website References Chapter 14: Neurotensin Discovery Structure Primary structural features Properties Synthesis and release Gene, mRNA, and precursor Tissue distribution of mRNA Tissue content Plasma concentration Regulation of synthesis and release Receptors Structure and subtype Signal transduction pathway Biological functions Target cells/tissues and functions Phenotype of gene-modified animals Pathophysiological implications Clinical implications Supplemental information available on companion website References Chapter 15: Neuromedin U/S Discovery Structure Structural features Primary structure Properties Synthesis and release Gene, mRNA, and precursor Distribution of mRNA Tissue content Regulation of synthesis Receptors Structure and subtype Signal transduction pathway Agonists Antagonist Biological functions Target cells/tissues and functions Phenotypes in gene-modified animals Pathophysiological implications Clinical implications Use for diagnosis and treatment Supplemental information available on companion website References Chapter 16: Neuropeptide S Discovery Structure Primary structural features Properties Synthesis and release Gene, mRNA, and precursor Tissue distribution of mRNA Tissue content Plasma concentration Regulation of synthesis and release Receptors Structure and subtype Signal transduction pathway Biological functions Target cells/tissues and functions Phenotype of gene-modified animals Pathophysiological implications Clinical implications Supplemental information available on companion website References Chapter 17: Neuropeptide W Discovery Structure Primary structural features Properties Synthesis and release Gene, mRNA, and precursor Tissue distribution of mRNA Tissue content Plasma concentration Regulation of synthesis and release Receptors Structure and subtype Signal transduction pathway Biological functions Target cells/tissues and functions Phenotype of gene-modified animals Pathophysiological implications Clinical implications Supplemental information available on companion website References Chapter 18: Neuroendocrine regulatory peptides Discovery Structure Structural features Primary structure Properties Synthesis and release Gene, mRNA, and precursor Distribution of mRNA Tissue and plasma concentrations Regulations of synthesis and release Receptors Biological functions Target cells/tissue and function Phenotype in gene-modified animals Pathophysiological implications References Chapter 19: Neurosecretory protein GL/neurosecretory protein GM Discovery Structure Structural features Primary structure Properties Synthesis and release Gene, mRNA, and precursor Distribution of mRNA Regulation of synthesis and release Receptors Agonist Biological functions Phenotype in gene-modified animals Pathophysiological implications Clinical implications Use for diagnosis and treatment Supplemental information available on companion website References Chapter 20: Nesfatin-1 Discovery Structure Primary structural features Properties Synthesis and release Gene, mRNA, and precursor Tissue distribution of mRNA Tissue content Plasma concentration Regulation of synthesis and release Receptors Structure and subtype Signal transduction pathway Biological functions Target cells/tissues and functions Phenotype of gene-modified animals Pathophysiological implications Clinical implications Supplemental information available on companion website References Chapter 21: Mexneurin Discovery Structure Structural features Primary structure Properties Synthesis and release Gene, mRNA, and precursor Distribution of mRNA Structure and subtype, signal transduction pathway, agonist, and antagonist Biological functions Target cells/tissues and functions Reference Chapter 22: Phoenixin Discovery Structure Structural features Primary structure Properties Synthesis and release Gene, mRNA, and precursor Distribution of mRNA Tissue and plasma concentrations Regulation of synthesis and release Receptors Structure and subtype, signal transduction pathway, agonist, and antagonist Biological functions Target cells/tissues and functions (Table 22.1) Pathophysiological implications Clinical implications References Section I-2: Adenohypophyseal hormones Chapter 23: Glycoprotein hormone family History Structure Structural features Molecular evolution of family members Receptors Structure and subtypes Signal transduction pathway Biological functions Target cells/tissues and functions Supplemental information available on companion website References Subchapter 23A: Follicle-stimulating hormone Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 23B: Luteinizing hormone Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 23C: Thyroid-stimulating hormone Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Chapter 24: Growth hormone/prolactin family History Structure Structural features Molecular evolution of family members Receptors Structure and subtypes Signal transduction pathway Biological functions Target cells/tissues and functions References Subchapter 24A: Growth hormone Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 24B: Prolactin Discovery Structure Synthesis and release Receptors Biological functions Phenotype in gene-modified animals (PRL1) Pathophysiological implications Supplemental information available on companion website References Subchapter 24C: Somatolactin Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Chapter 25: Proopiomelanocortin family History Structure Structural features Molecular evolution of family members Receptors Structure and subtype Interaction with of melanocortin-2 receptor accessory protein (MRAP) Signal transduction pathway Biological functions Target cells/tissues and functions Supplemental information available on companion website References Subchapter 25A: Adrenocorticotropic hormone Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 25B: Melanocyte-stimulating hormone Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 25C: Endorphin Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Section I-3: Gastrointestinal hormones Chapter 26: Glucagon family History Structure Structural features Molecular evolution of family members Receptors Structure and subtypes Signal transduction pathway Biological functions Target cells/tissues and functions Supplemental information available on companion website References Subchapter 26A: Glucagon Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 26B: Gastric inhibitory peptide Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 26C: Glucagon-like peptide-1 Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 26D: Glucagon-like peptide-2 Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Chapter 27: Secretin/pituitary adenylate cyclase-activating polypeptide family History Structure Structural features Molecular evolution of family members Receptors Structure and subtypes Signal transduction pathway Biological functions Target cells/tissues and functions Supplemental information available on companion website References Subchapter 27A: Secretin Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 27B: Growth hormone-releasing hormone Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 27C: Pituitary adenylate cyclase-activating polypeptide Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications References Subchapter 27D: Pituitary adenylate cyclase-activating polypeptide-related peptide Discovery Structure Synthesis and release Receptors Biological functions References Subchapter 27E: Vasoactive intestinal peptide Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 27F: Peptide histidine isoleucine/methionine Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications References Chapter 28: Insulin family History Structure Structural features Molecular evolution of family members Receptors Structure and subtypes Biological functions Target cells/tissues and functions Supplemental information available on companion website References Subchapter 28A: Insulin Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 28B: Insulin-like growth factor-1 Discovery Structure Synthesis and release Receptors Biological functions Pathological implications Supplemental information available on companion website References Subchapter 28C: Insulin-like growth factor-2 Discovery Structure Synthesis and release Receptors Biological functions Pathological implications Supplemental information available on companion website References Subchapter 28D: Insulin-like growth factor binding proteins Discovery Structure Synthesis and release Receptors Biological functions Pathological implications Supplemental information available on companion website References Subchapter 28E: Relaxins Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Chapter 29: Gastrin family History Structure Structural features Molecular evolution of gastrin family members Receptors Structure and subtypes Signal transduction pathways Biological functions Target cells/tissues and functions Supplemental information available on companion website References Subchapter 29A: Gastrin Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 29B: Cholecystokinin Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 29C: Caerulein Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Chapter 30: Ghrelin-motilin family History Structure Structural features Receptors Structure and subtypes Signal transduction pathway Biological functions Target cells/tissues and functions Supplemental information available on companion website References Subchapter 30A: Ghrelin Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 30B: Motilin Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Chapter 31: Bombesin-like peptide family History Structure Structural features Receptors Structure and subtypes Signal transduction pathway Biological functions Target cells/tissues and functions Phenotype of gene-modified animals Pathophysiological implications Supplemental information available on companion website References Subchapter 31A: Gastrin-releasing peptide Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 31B: Neuromedin B Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Chapter 32: Guanylin family History Structure Structural features Molecular evolution of family members Receptors Structure and subtypes Signal transduction pathway Biological functions Target cells/tissues and functions Supplemental information available on companion website References Subchapter 32A: Guanylin Discovery Structure Synthesis and release Plasma concentration Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 32B: Uroguanylin Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Chapter 33: Galanin peptide family History Structure Structural features Molecular evolution of family members Receptors Structure and subtypes Signal transduction pathway Biological functions Target cells/tissues and functions Supplemental information available on companion website References Subchapter 33A: Galanin Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 33B: Galanin-like peptide Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 33C: Alarin Discovery Structure Synthesis and release Receptors Biological functions Supplemental information available on companion website References Chapter 34: Neuropeptide Y family History Structure Structural features Molecular evolution of family members Receptors Structure and subtypes Signal transduction pathway Biological functions Target cells/tissues and functions Supplemental information available on companion website References Subchapter 34A: Pancreatic polypeptide Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 34B: Neuropeptide Y Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 34C: Peptide YY Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Chapter 35: Xenin Discovery Structure Structural features Primary structure Properties Gene, mRNA, and precursor Distribution of mRNA Tissue and plasma concentrations Regulation of synthesis and release Receptors Structure and subtypes Signal transduction pathway Agonists Antagonists Biological functions Target cells/tissues and functions Pathophysiological implications Clinical implications Use for diagnosis and treatment References Section I.4: Parathyroid gland, ultimobranchial gland and stannius corpuscle hormones Chapter 36: Parathyroid hormone family History Structure Structural features Molecular evolution of family members Receptors Structure and subtypes Signal transduction pathway Biological functions Target cells/tissues and functions Supplemental information available on companion website References Subchapter 36A: Parathyroid hormone Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 36B: Parathyroid hormone-related protein Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 36C: Tuberoinfundibular peptide of 39 amino acids Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Chapter 37: Calcitonin/calcitonin gene-related peptide family History Structure Structural features Molecular evolution of family members and peptides Receptors Structure and subtypes Signal transduction pathway Biological functions Target cells/tissues and functions Supplemental information available on companion website References Subchapter 37A: Calcitonin Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 37B: Calcitonin gene-related peptide Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 37C: Calcitonin receptor-stimulating peptide Discovery Structure Synthesis and release Receptors Biological functions Supplemental information available on companion website References Subchapter 37D: Adrenomedullin Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 37E: Adrenomedullin 2 and 5 Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 37F: Amylin Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Chapter 38: Stanniocalcin Discovery Structure Structural features Primary structure Properties Synthesis and release Gene and mRNA Tissue distribution of mRNA Tissue content Plasma concentration Regulation of synthesis and release Receptors Biological functions Target cells/tissues and functions (Table 38.1) Phenotype of gene-modified animals Pathophysiological implications Relationship to cancers Relationship to lipid metabolism Supplemental information available on companion website References Section I.5: Cytokines Chapter 39: Immunological modulators History Structures and biological functions References Subchapter 39A: Interleukins Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 39B: Tumor necrosis factor Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchapter 39C: Interferons Discovery Structure and synthesis Receptors and signaling pathways Biological functions Pathophysiological implications Supplemental information available on companion website References Chapter 40: Hematopoietic growth factors History Structure Structural features Molecular evolution of family members Receptors Structure and subtypes Signal transduction pathway Biological functions Target cells/tissues and functions Supplemental information available on companion website References Subchapter 40A: Erythropoietin Discovery Structure Synthesis and release Receptors Biological functions Pathophysiological implications Supplemental information available on companion website References Subchap

Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research, Second Edition presents a catalog of fundamental information on the structure and function of hormones from basic biology to clinical use, offering a rapid way to obtain specific facts about the chemical and molecular characteristics of hormones, their receptors, signaling pathways, and the biological activities they regulate. The book's stellar editorial board, affiliated with the Japan Society for Comparative Endocrinology, brings together authors that present a compelling structure of each hormone with a consistent presentation that provides a primer surrounding the plethora of hormones that now exist.

Comparative endocrinology continues to rapidly expand and new information about hormones is being produced almost daily, making it important to stay up-to-date. Hormone, paracrine, and autocrine factors have been identified as key players in a range of different systems, including immune, musculoskeletal and cardiovascular. Frontiers between disciplines are being blurred and many scientists in fields other than endocrinology are interested in hormones. Scientists now have the unprecedented opportunity to look from invertebrates to vertebrate and identify novel regulatory factors and understand their function and how they determine an organism’s physiology and survival.

• Presents hormones in groups according to their origin so that readers can easily understand their inter-relation
• Includes 47 new hormones, such as neuropeptides, cytokines, growth hormones, biogenic amines and amino acids that are important for cell to cell communication via endocrine, paracrine and neurotransmitter signaling
• Summarizes the current knowledge of hormone evolution based on comparative genome resources, such as synteny, genome sequence and comprehensive phylogeny
• Covers a wide range of information on hormones, from basic information on structure and function across vertebrate and invertebrate phyla to clinical applications
• Collates key information on 259 hormones and 47 groups/families