Handbook of Harnessing Biomaterials in Nanomedicine : Preparation, Toxicity, and Applications

This book concentrates on the use of biomaterials in nanomedicine. The areas of focus include drug delivery by polymers, lipids, and carbohydrates for the delivery of small molecules, RNA interference, and proteins; the use of nano-proteins such as antibodies and peptides as targeting agents for therapeutics and diagnosis; the use of nanocarrier-based biomaterials for manipulation of stem cells; different aspects of toxicity of nanocarriers (the immune response, liver toxicity, and many more); and success stories of biomaterials that have reached the clinics. The book covers theoretical and experimental analysis of various biomaterials that are used in nanomedicine, research methods and preparation techniques, and several promising applications. Content: Biomaterial-Based Particulate Drug Carriers, R. Margalit Single-Chain Polymer Nanoparticles for Application in Nanomedicine, I. Loinaz Polyethylene Glycol Polyester Block Co-Polymers: Biocompatible Carriers for Nanoparticulate Drug Delivery, M. L. Forrest Recent Progress in Polymer Therapeutics as Nanomedicines, R. Satchi-Fainaro Polysaccharides as Nanomaterials for Therapeutics, D. Peer RNAi as New Class of Nanomedicines, D. M. Dykxhoorn Novel RNA Interference (RNAi)-Based Nanomedicines for Treating Viral Infections, P. Kumar Detection and Description of Tissue Disease: Advances in the Use of Nanomedicine for Medical Imaging, J. L. Dearling and A. B. Packard Image-Based High-Content Analysis, Stem Cells and Nanomedicines: A Novel Strategy for Drug Discovery, M. Weil Wrong Resemblance? Role of the Immune System in the Biocompatibility of Nanostructured Materials, T. Vorup-Jensen Complement Activation, Immunogenicity and Immune Suppression as Potential Side Effects of Liposomes, J. Szebeni and Y. Barenholz The Story of DOXIL - A Personal Account, Y. Barenholz Front Cover 1 Contents 6 Preface 16 1. Biomaterial-Based Particulate Drug Carriers 18 2. Single-Chain Polymer Nanoparticles for Application in Nanomedicine 38 3. Polyethylene Glycol Polyester Block Copolymers: Biocompatible Carriers for Nanoparticulate Drug Delivery 60 4. Recent Progress in Polymer Therapeutics as Nanomedicines 94 5. Polysaccharides as Nanomaterials for Therapeutics 140 6. RNAi as New Class of Nanomedicines 180 7. Novel RNA Interference (RNAi)-Based Nanomedicines for Treating Viral Infections 216 8. Detection and Description of Tissue Disease: Advances in the Use of Nanomedicine for Medical Imaging 258 9. Image-Based High-Content Analysis, Stem Cells and Nanomedicines: A Novel Strategy for Drug Discovery 278 10. Wrong Resemblance? Role of the Immune System in the Biocompatibility of Nanostructured Materials 300 11. Complement Activation, Immunogenicity, and Immune Suppression as Potential Side Effects of Liposomes 326 12. Doxil®- The First FDA-Approved Nano-Drug: From an Idea to a Product 352 Color Insert 416 This book concentrates on the use of biomaterials in nanomedicine. The areas of focus include drug delivery by polymers, lipids and carbohydrates for the delivery of small molecules, RNA interference, and proteins; the use of nano-proteins such as antibodies and peptides as targeting agents for therapeutics and diagnosis; The use of nanocarrier-based biomaterials for manipulation of stem cells; different aspects of toxicity of nanocarriers (the immune response, liver toxicity, and many more); and success stories of biomaterials that have reached the clinics. The book comprises theoretical and experimental analysis of various biomaterials that are used in nanomedicine, research methods and preparation techniques, and several promising applications.