Handbook of drug monitoring methods : therapeutics and drugs of abuse

In Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse, authors discuss the different analytical techniques used in today’s practice of therapeutic drug monitoring and drugs of abuse as well as alcohol testing with relevant theory, mechanism, and in-depth scientific discussion on each topic. This volume is the perfect handbook and quick reference for any clinical laboratory, allowing clinicians to find the potential source of a false-positive or a false-negative result in the daily operation of a toxicology laboratory. At the same time, this book can also be used as a reference for medical technologists, supervisors, laboratory directors, clinical chemists, toxicologists, and pathologists to find in-depth cause of a potential interference and what tests can be ordered to circumvent such problem. The volume’s first half focuses on various issues of therapeutic drug monitoring. Additional chapters cover analysis of heavy metals, alcohol testing, and issues of drugs of abuse testing. These chapters are written by experts in their relative sub-specialties and also by the editor. Comprehensive and timely, Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse is the ideal text for clinicians and researchers monitoring alcohol and drug testing and other important tasks of toxicological laboratory services. Doody Review Services Reviewer: Valerie L. Ng, PhD MD(Alameda County Medical Center/Highland Hospital) Description: This is a comprehensive handbook on all aspects of drug monitoring. Purpose: The purpose of this book is twofold. The first is to provide a quick and handy technology reference for the bench technologist performing drug testing. The second is to provide a reference which clinical users of drug test results can use to interpret the results. Both of these worthy objectives are well met by this book. Audience: This has broad appeal. Of course it would appeal to anyone actively measuring drug levels (i.e., clinical laboratory scientists, toxicologists, clinical chemists). It would also appeal to anyone interested in how such testing is performed and the pitfalls in interpreting results (students or practitioners in any medical discipline or allied health field, poison control centers, concerned parents, etc.). The editor is internationally recognized for his expertise in this area, and all authors are very credible authorities. Features: This book packs more information than you would think possible in a 7 x 10 x 1 inch book. The 22 chapters cover pretty much anything you might ever want to know about drug monitoring. Early chapters discuss basic introductory matters (i.e., methods, when to measure free versus bound drug, etc.) followed by chapters focusing on drug classes (e.g., digoxin, antidepressants, immunosuppresives). Then a group of chapters discusses issues commonly encountered with drug testing - interferents (lipis, hemolysis, bilirubin), herb interactions, different specimen types (blood versus urine versus saliva versus hair), specimen adulterants and interpretation of results. I especially appreciated the chapter on clinical false positive drug test results, which was full of useful information. Where else could you learn that use of Vicks inhalers can potentially yield a false positive amphetamine result? Or what adulterants are frequently used to obscure evidence of drug abuse? Or what do you need to be mindful of when testifying about drug levels you measured for legal cases? You've got to buy the book to get these answers. These are exactly the questions I get most frequently, and the answers are all here in one convenient location. Of note, this book would be a nice cornerstone to a small group of specialty books collectively covering the majority of toxicology and drugs of abuse testing: Narayan and Young's Effects of Herbs and Natural Products on Clinical Laboratory Tests (AACC Press, 2007), Hammett-Stabler and DasGupta's Therapeutic Drug Monitoring Data, 3rd edition (AACC Press, 2007), Jenkins and Goldberger's On-Site Drug Testing (Humana Press, 2002), and Wong and Tse's Drugs of Abuse: Body Fluid Testing (Humana Press, 2005). Assessment: This is a very nice addition to the field of drug testing and monitoring. If for nothing else, get it to impress your colleagues when you can definitively answer the frequent question, "How many poppy seed bagels can I eat without having my urine test positive for drugs of abuse?" pp001-039.pdf -1 Introduction to Therapeutic Drug Monitoring 11 Amitava Dasgupta 11 pp041-065.pdf -1 Monitoring Free Drug Concentration 51 Amitava Dasgupta 51 pp067-086.pdf -1 Analytical Techniques for Measuring Concentrations of Therapeutic Drugs in Biological Fluids 77 Amitava Dasgupta and Pradip Datta 77 pp087-096.pdf -1 The Pre-Analytical Phaseof Drug Testing 97 Catherine A. Hammett-Stabler 97 pp097-109.pdf -1 Effect of Hemolysis, High Bilirubin, Lipemia, Paraproteins, and System Factors on Therapeutic Drug Monitoring 107 Pradip Datta 107 pp111-131.pdf -1 Digoxin 121 Amitava Dasgupta 121 pp133-148.pdf -1 Interferences with Measurement of Anticonvulsants 143 William Clarke 143 pp148-163.pdf -1 Pitfalls in Measuring Antidepressant Drugs 159 Uttam Garg 159 pp165-199.pdf -1 Immunosuppressive Drugs 175 Anthony W. Butch 175 pp201-210.pdf -1 Therapeutic Drug Monitoring in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome 211 Steven J. Soldin 211 pp211-223.pdf -1 Pharmacogenomics and Personalized Medicine 221 Steven H. Y. Wong 221 pp225-233.pdf -1 Interference of Heterophilic and Other Antibodies in Measurement of Therapeutic Drugs by Immunoassays 235 Pradip Datta 235 pp235-261.pdf -1 Drug--Herb and Drug--Food Interactions 245 Amitava Dasgupta 245 pp263-282.pdf -1 Toxic Element Testing with Clinical Specimens 273 Gwendolyn A. McMillin and Joshua A. Bornhorst 273 pp283-295.pdf -1 Alcohol Testing 293 Steve C. Kazmierczak and Hassan M. E. Azzazy 293 pp297-315.pdf -1 Introduction to Drugs of Abuse Testing 307 Tai C. Kwong 307 pp317-335.pdf -1 Urinary Adulterants and Drugs of Abuse Testing 327 Amitava Dasgupta 327 pp337-364.pdf -1 Hair, Oral Fluid, Sweat, and Meconium Testing for Drugs of Abuse 347 Uttam Garg 347 pp365-377.pdf -1 Abused and Designer Drugs and How They Escape Detection 375 Barry Levine and Rebecca Jufer-Phipps 375 pp379-393.pdf -1 Interpretation of Amphetamines Screening and Confirmation Testing 389 Larry Broussard 389 pp395-406.pdf -1 Clinical False-Positive Drug Test Results 405 Tai C. Kwong 405 pp407-420.pdf -1 Providing Expert Witness for Alcohol and Positive Drugs of Abuse Test Results 417 Andrea Terrell, William Clarke, Michael Evans, and Jennifer Collins 417 "In Handbook of Drug Monitoring Methods: Therapeutics and Drugs of Abuse, authors discuss the different analytical techniques used in today's practice of therapeutic drug monitoring and drugs of abuse as well as alcohol testing, with relevant theory, mechanism, and in-depth scientific discussion on each topic. This volume is the perfect handbook and quick reference for any clinical laboratory, allowing clinicians to find the potential source of a false-positive or a false-negative result in the daily operation of a toxicology laboratory. At the same time, this book can also be used as a reference for medical technologists, supervisors, laboratory directors, clinical chemists, toxicologists, and pathologists to find the in-depth cause of a potential interference and what tests can be ordered to circumvent such a problem."--Jacket Written in a handbook style with specific methods and tips on eliminating false positive and false negative results, this book is a practical guide to the detailed mechanisms of such occurrences.