Handbook of chemical glycosylation : advances in stereoselectivity and therapeutic relevance

Since carbohydrate oligomers are still a challenge in synthetic chemistry, this book on recent developments fulfils a great need. Covering the chemistry necessary to synthesize exact copies of these structures, top authors from all around the world comprehensively deal with synthesis from anomeric halides, from miscellaneous glycosyl donors, and by indirect and special methods, as well as 1-oxygen-and 1-sulfur-substituted derivatives. They demonstrate the best approach for the stereoselective formation of the intermonomeric bond, making this essential reading for every biochemist working in biosynthesis, the exploration of biopathways and vaccines.Content: Chapter 1 General Aspects of the Glycosidic Bond Formation (pages 1–27): Prof. Dr. Alexei V. Demchenko Chapter 2 Glycoside Synthesis from Anomeric Halides (pages 29–93): Shin?Ichiro Shoda, Suvarn S. Kulkarni and Jacquelyn Gervay?Hague Chapter 3 Glycoside Synthesis from 1?Oxygen Substituted Glycosyl Donors: Sections 3.1 and 3.2 (pages 95–185): Daniel A. Ryan, David Y. Gin, Xiangming Zhu and Richard R. Schmidt Chapter 3 Glycoside Synthesis from 1?Oxygen Substituted Glycosyl Donors: Sections 3.3 and 3.4 (pages 185–259): Kwan?Soo Kim, Heung?Bae Jeon, Seiichi Nakamura, Hisanori Nambu and Shunichi Hashimoto Chapter 4 Glycoside Synthesis from 1?Sulfur/Selenium?Substituted Derivatives: Sections 4.1 and 4.2 (pages 261–329): Wei Zhong, Geert?Jan Boons, David Crich and Albert A. Bowers Chapter 4 Glycoside Synthesis from 1?Sulfur/Selenium?Substituted Derivatives: Sections 4.3 and 4.4 (pages 329–379): Wieslaw Szeja, Grzegorz Grynkiewicz and Robert A. Field Chapter 5 Other Methods for Glycoside Synthesis: Sections 5.1 and 5.2 (pages 381–448): Bert Fraser?Reid, J. Cristobal Lopez, David W. Gammon and Bert F. Sels Chapter 5 Other Methods for Glycoside Synthesis: Sections 5.3 and 5.4 (pages 449–496): Kazunobu Toshima and Thomas Ziegler The Biochemical Basis And Coding Capacity Of The Sugar Code / Harold Rüdiger And Hans-joachim Gabius -- Three-dimensional Aspects Of The Sugar Code / Tibor Kožár ... [et Al.] -- The Chemist's Way To Synthesize Glycosides / Stefan Oscarson -- The Chemist's Way To Prepare Multivalency / Yoann M. Chabre And René Roy -- Analytical Aspects : Analysis Of Protein-bound Glycans / Hiroaki Nakagawa -- Natural Glycosylation : Glycoproteins -- N-glycosylation / Christian Zuber And Jürgen Roth -- O-glycosylation : Structural Diversity And Functions / Georgios Patsos And Anthony Corfield -- Glycosylation Of Model And Lower Organisms / Iain B.h. Wilson, Katharina Paschinger, And Dubravko Rendić -- Glycosylphosphatidylinositol Anchors : Structure, Biosynthesis And Functions / Hosam Shams-eldin, Françoise Debierre-grockiego, And Ralph T. Schwarz -- Natural Glycosylation : Glycolipids, Proteoglycans And Chitin -- Glycolipids / Jürgen Kopitz -- Proteoglycans / Eckhart Buddecke --^ Chitin / Hans Merzendorfer -- Protein-carbohydrate Interactions -- Protein-carbohydrate Interactions : Basic Concepts And Methods For Analysis / Dolores Solís ... [et Al.] -- How To Determine Specificity : From Lectin Profiling To Clycan Mapping And Arrays / Hiroaki Tateno, Atsushi Kuno, And Jun Hirabayashi -- The History Of Lectinology / Harold Rüdiger And Hans-joachim Gabius -- Ca2+ : Mastermind And Active Player For Lectin Activity (including A Gallery Of Lectin Folds) / Hans-joachim Gabius -- Bacterial And Viral Lectins / Jan Holgersson, Anki Gustafsson, And Stefan Gaunitz -- Plant Lectins / Harold Rüdiger And Hans-joachim Gabius -- Animal And Human Lectins / Hans-joachim Gabius -- Routes In Lectin Evolution : Case Study On The C-type Lectin-like Domains / Jill E. Gready And Alex N. Zelenksy -- Carbohydrate-carbohydrate Interactions / Iwona Bucior, Max M. Burger, And Xavier Fernàndez-busquets -- Biomedical Aspects And Case Studies --^ Diseases Of Glycosylation / Thierry Hennet -- Animal Models To Delineate Glycan Functionality / Koichi Honke And Naoyuki Taniguchi -- Glycobiology Of Fertilization And Early Embryonic Development / Felix A. Habermann And Fred Sinowatz -- Glycans As Functional Markers In Malignancy? / Sabine André ... [et Al.] -- Small Is Beautiful : Mini-lectins In Host Defense / Robert I. Lehrer -- Inflammation And Glycosciences / Reinhard Schwartz-albiez -- Sugars As Pharmaceuticals / Helen M.i. Osborn And Andrea Turkson -- Platelet Glycoproteins As Lectins In Hematology / Karin Hoffmeister And Hervé Falet -- Neurobiology Meets Glycosciences / Robert W. Ledeen And Gusheng Wu. Edited By Hans-joachim Gabius. Includes Bibliographical References And Index.

Carbohydrates play a central role in metabolism, cell-cell recognition, and pathogen defense. To exploit the full potential of this diverse compound class for the development of pharmaceutically active substances, this handbook brings together the latest in carbohydrate chemistry with recent knowledge on the biological function of carbohydrates and their derivatives.

Particular emphasis is placed on carbohydrates with pharmaceutical potential, including the most promising carbohydrate-based therapies currently available.

From the Contents:

• Complex Carbohydrate Synthesis

• Solid-Phase Carbohydrate Synthesis

• Glycopeptides and Glycoproteins

• Synthetic Carbohydrate-based Vaccines and Antibiotics

• Carbohydrate Mimetics

• Sequencing of Oligosaccharides and Glycoproteins

• Carbohydrate Microarrays

• Multivalent Carbohydrate Ligands

• Glycosylated Natural Products

• Glycosyltransferase Inhibitors

• Sulfotransferase Inhibitors

• Carbohydrate-based Treatment of Cancer

• N-Acetylneuraminic Acid Derivatives as Anti-influenza Agents

• Aminoglycosides and Macrolides in RNA Recognition

A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume handbook contains contributions by more than 80 leading carbohydrate chemists.

Carbohydrate Chemistry and Glycobiology have witnessed a rapid expansion during the last few years with the development of numerous new, imaginative and efficient syntheses which provide further insight into structures and biological interactions of glycoconjugates. Glycosylation reactions are widely used in the synthesis of pharmaceuticals and bio-active compounds. In biology and medicine oligosaccharides play a central role in immuno-stimulation, cancer or allergic responses. Glycoscience is a very instructive example of how one common topic of interest stimulates both chemistry and biology to collectively open scientific frontiers.
This synergy is made visible in this work. Three leading experts in the fields of Glycochemistry and Glycobiology have invited numerous renowned authors to provide a comprehensive overview of the recent advances and findings in Glycoscience. This four-volume handbook presents an integrated and cutting-edge view, and covers all chemical aspects, such as syntheses and analysis of carbohydrates and oligosaccharides, as well as the biological role and activity of oligosaccharides and carbohydrate/protein interactions.

since Carbohydrate Oligomers Are Still A Challenge In Synthetic Chemistry, This Book On Recent Developments Fulfils A Great Need. Covering The Chemistry Necessary To Synthesize Exact Copies Of These Structures, Top Authors From All Around The World Comprehensively Deal With Synthesis From Anomeric Halides, From Miscellaneous Glycosyl Donors, And By Indirect And Special Methods, As Well As 1-oxygen-and 1-sulfur-substituted Derivatives. They Demonstrate The Best Approach For The Stereoselective Formation Of The Intermonomeric Bond, Making This Essential Reading For Every Biochemist Working In Biosynthesis, The Exploration Of Biopathways And Vaccines.

To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following:> Chemical Synthesis of Carbohydrates> Carbohydrate Biosynthesis and Metabolism> Carbohydrate Analysis> Cellular Functions of Carbohydrates> Development of Carbohydrate-based DrugsA premier resource for carbohydrate chem A reader friendly overview of the structure and functional relevance of natural glycosylation and its cognate proteins (lectins), this book is also one of the few books to cover their role in health and disease. Edited by one of the pioneering experts in the field and written by a team of renowned researchers this resource is a perfect introduction for all students in life and medical sciences, biochemistry, chemistry and pharmacy. (http://WWW.WILEY-VCH.DE/HOME/THESUGARCODE) WWW.WILEY-VCH.DE/HOME/THESUGARCODE Written by carbohydrate chemists, this handbook is a resource on carbohydrate chemistry and biochemistry. Aimed at carbohydrate chemists and drug developers, this two-volume work focuses on carbohydrates with pharmaceutical potential. It covers topics such as: chemical synthesis of carbohydrates; development of carbohydrate-based drugs; and more. pt. 1. Chemistry of saccharides, v. 1. Chemical synthesis of glycosides and glycomimetics v.2. Enzymatic synthesis of glycosides and carbohydrate receptor interaction pt. 2. Biology of saccharides, v. 3. Biosynthesis and degradation of glycoconjugates v.4. Lectins and saccharide biology (v.1-2 comprise pt.1; v.3-4 comprise pt.2). This is a comprehensive multi-author, multi-volume text written by experts in the field on oligosaccharides in chemistry and biology. Every article starts with a summary of about two pages, designed for rapid browsing, and then further information is given about the described method. This book is an overview of the structure and functional relevance of natural glycosylation and its cognate proteins (lectins), this book is also one of the few books to cover their role in health and disease.