Handbook of Ataxia Disorders (Neurological Disease and Therapy)

This timely reference presents, for the first time, new findings in molecular genetics that are applicable to the epidemiology, pathogenesis, neuropathology, clinical features, and management of ataxia-bridging the gap between scientific and clinical practice. Organized by the distinctive ataxia disorders, their pathogenesis, and management-facilitating quick and efficient diagnoses! Providing complementary sections on the anatomy of the spinocerebellar system, its normal function, and a history of ataxia research and management, the Handbook of Ataxia Disorders ·clarifies the impact of identifying the molecular causes of ataxia ·offers in-depth analysis of dominant and recessive and nonhereditary ataxia disorders ·explores the vital connection between the genotypes and phenotypes of various degenerative ataxia disorders ·and more! Written by more than 60 international experts and supplemented with over 2600 literature references, photographs, micrographs, drawings, and tables, the Handbook of Ataxia Disorders is an essential and useful reference for clinical neurologists and neuropathologists, neuropediatricians, geneticists, physiatrists, and medical school students in these disciplines.

this Timely Reference Presents, For The First Time, New Findings In Molecular Genetics That Are Applicable To The Epidemiology, Pathogenesis, Neuropathology, Clinical Features, And Management Of Ataxia-bridging The Gap Between Scientific And Clinical Practice.
organized By The Distinctive Ataxia Disorders, Their Pathogenesis, And Management-facilitating Quick And Efficient Diagnoses!

providing Complementary Sections On The Anatomy Of The Spinocerebellar System, Its Normal Function, And A History Of Ataxia Research And Management, The Handbook Of Ataxia Disorders
• Clarifies The Impact Of Identifying The Molecular Causes Of Ataxia
• Offers In-depth Analysis Of Dominant And Recessive And Nonhereditary Ataxia Disorders
• Explores The Vital Connection Between The Genotypes And Phenotypes Of Various Degenerative Ataxia Disorders
• And More!
written By More Than 60 International Experts And Supplemented With Over 2600 Literature References, Photographs, Micrographs, Drawings, And Tables, The Handbook Of Ataxia Disorders Is An Essential And Useful Reference For Clinical Neurologists And Neuropathologists, Neuropediatricians, Geneticists, Physiatrists, And Medical School Students In These Disciplines.

doody Review Services

reviewer:ronald Sims, Md(dubuque Internal Medicine)
description:this Is A Comprehensive Review Of Ataxia Disorders.
purpose:it Is Intended To Be A Practical Guide For Clinicians And To Serve As A Reference For Neuroscientists And Geneticists. These Objectives Are Appropriate, Given The Rapid Advances In Knowledge And The Complexity Of Ataxia Disorders, And They Are Accomplished With Great Success.
audience:like Most Volumes In The Neurological Disease And Therapy Series, This Book Is Written At A Level That Surpasses The Fund Of Knowledge Of Most General Neurologists. The Authors, Who Number More Than 60, Are Recognized Experts From North American And European Medical Centers.
features:all Aspects Of Interest To A Clinician Are Covered, Including The Structure And Function Of The Cerebellar System, Developmental Factors, Pathology, Inherited And Acquired Ataxias, And The Clinical Approach To Ataxia. The Book Provides Much More Extensive Information Than That Available In General Neurology Texts, And Is Especially Strong In Presenting Advances Related To Molecular Genetics. The Inclusion Of More Photographs Or Even A Cd-rom To Illustrate Physical Signs Such As Tremor, Ataxia, Dysarthria, And Oculomotor Disorders Would Have Been Useful.
assessment:this Is Excellent And Well Worth Owning. It Is Currently The Best Source On This Topic.

HandbookofAtaxiaDisorders......Page 2 Copyright 0 2000......Page 7 P ref ace......Page 10 ontents......Page 12 Contributors......Page 16 1 Functional Architectureof the Cerebellar System......Page 24 Normal Functions of theC~rebell~......Page 76 History of Ataxia Research......Page 100 Clinical Approach to Ataxic Patients......Page 124 5 cerebellar malformations......Page 138 6 Friedreich ́s Ataxia......Page 174 Ataxia-Telangiectasia......Page 186 Early-Onset Cerebellar Ataxia withRetained Tendon Reflexes......Page 214 abetalipoproteinemia......Page 228 10Ataxia with Isolated Vitamin EDeficiency......Page 246 Heredopathia AtacticaPolyneuritiformisRefsum’s Disease......Page 258 Cerebrotendinous Xanthomatosis......Page 280 Ataxias associated with rare metabolic disorders......Page 294 Infantile-Onset SpinocerebellarAtaxia......Page 316 Autosomal Recessive SpasticAtaxia (Charlevoix-Saguenay)......Page 334 ATAXIA IN MITOCHONDRIAL DISORDERS......Page 348 Spinocerebellar Ataxia 1......Page 366 Spinocerebellar Ataxia Type 2......Page 386 Spinocerebellar Ataxia Type 3Machado-Joseph Disease......Page 408 Spinocerebellar Ataxia Type 4......Page 448 Spinocerebellar Ataxia Type 5......Page 458 Episodic Ataxia Type 2 andSpinocerebellar Ataxia Type 6......Page 470 Spinocerebellar Ataxia Type 7......Page 492 Episodic Ataxia Type 1......Page 510 Spinocerebellar Ataxia Type 10......Page 540 Ataxia in the TransmissibleSpongiform Encephalopathies......Page 546 Idiopathic Cerebellar DegenerationMultiple System Atrophy......Page 568 Alcoholic Cerebellar Degeneration(including Ataxias That Are Dueto Other Toxic Causes)......Page 594 Paraneoplastic CerebellarDegeneration......Page 630 Ataxia Caused by ~cquiredW itaminDeficiency or etabolic Disorders......Page 656 Cerebellar Encephalitis......Page 672 Ataxia due to physical causes......Page 690 Index......Page 700 Although the volume of the cerebellum is only one-seventh that of the cerebrum, the term cerebellum i.e., the small brain, is misleading, because it is small only in volume.