Gtpases In Biology Ii (handbook Of Experimental Pharmacology)

Recent advances in molecular biology have shown GTPases and phosphoproteins to be the paramount molecular switches uti- lized intracellularly in biological systems. The origins of the GTPase switch appear to be almost as ancient as life it- self, and through evolution nature has adapted this switch to a variety of purposes. In this two-volume work a broad survey of the major classes of GTPases is presented. The role of GTPases in ensuring ac- curacy during protein translation, a new look at the trimeric G-protein cycle, the molecular function of ARF in vesicle coating, the emerging role of the dynamin family in vesicle transfer, GTPases which activate GTPases during nascent protein translocation, and the many roles of ras-related proteins in growth, cytoskeletal polymerization, and vesicle transfer, are all described in 80 chapters by the leading authorities in their fields. Both detailed knowledge of specific systems or proteins and general principles of structure and function are offered. Much of this information has never been published before. At the rate the extended family of GTPases is growing it becomes increasingly unlikely that we will again get it to sit for a group portrait such as this. Therefore, the volume has the chance to become t h e reference work for GTPases. Front Matter....Pages I-XL Front Matter....Pages 1-1 Molecular Diversity of Mammalian Adenylyl Cyclases: Functional Consequences....Pages 189-212 The Light-Regulated cGMP Phosphodiesterase of Vertebrate Photoreceptors: Structure and Mechanism of Activation by G tα ....Pages 213-223 High-Voltage Activated Ca 2+ Channel....Pages 225-238 Phospholipase C-β Isozymes Activated by Gα q Members....Pages 239-249 Stimulation of Phospholipase C by G-Protein βγ Subunits....Pages 251-264 Rhodopsin/G-Protein Interaction....Pages 267-290 Fast Kinetics of G-Protein Function In Vivo....Pages 291-302 The Yeast Pheromone Response G-Protein....Pages 303-318 Gα Proteins in Drosophila : Structure and Developmental Expression....Pages 319-334 G-Proteins Have Properties of Multimeric Proteins: An Explanation for the Role of GTPases in their Dynamic Behavior....Pages 3-14 The Superfamily: Molecular Modelling....Pages 17-31 The Role of Receptor Kinases and Arrestin-Like Proteins in G-Protein-Linked Receptor Desensitization....Pages 33-42 Qualitative and Quantitative Characterization of the Distribution of G-Protein α Subunits in Mammals....Pages 45-64 Subunit Interactions of Heterotrimeric G-Proteins....Pages 65-78 G-Protein α Subunit Chimeras Reveal Specific Regulatory Domains Encoded in the Primary Sequence....Pages 79-97 The GTPase Cycle: Transducin....Pages 99-117 Transcriptional, Posttranscriptional, and Posttranslational Regulation of G-Proteins and Adrenergic Receptors....Pages 119-130 G-Protein Subunit Lipidation in Membrane Association and Signaling....Pages 131-146 Phosphorylation of Heterotrimeric G-Protein....Pages 147-165 Receptor to Effector Signaling Through G-Proteins: βγ Dimers Join α Subunits in the World of Higher Eukaryotes....Pages 167-186 Front Matter....Pages 1-1 Signal Transduction by G-Proteins in Dictyostelium discoideum ....Pages 335-349 Functional Expression of Mammalian Receptors and G-Proteins in Yeast....Pages 351-362 G-Proteins in the Signal Transduction of the Neutrophil....Pages 363-373 Hormonal Regulation of Phospholipid Metabolism via G-Proteins: Phosphoinositide Phospholipase C and Phosphatidylcholine Phospholipase D....Pages 375-385 Hormonal Regulation of Phospholipid Metabolism via G-proteins II: PLA 2 and Inhibitory Regulation of PLC....Pages 387-400 G-Protein Regulation of Phospholipase C in the Turkey Erythrocyte....Pages 401-415 Hormonal Inhibition of Adenylyl Cyclase by α i and βγ, α i orβγ, α i and/or βγ....Pages 417-428 Neurobiology of G o ....Pages 429-446 Involvement of Pertussis-Toxin-Sensitive G-Proteins in the Modulation of Ca 2+ Channels by Hormones and Neurotransmitters....Pages 447-469 Regulation of Cell Growth and Proliferation by G o ....Pages 471-484 Role of Nucleoside Diphosphate Kinase in G-Protein Action....Pages 485-498 G-Protein Regulation of Cardiac K + Channels....Pages 499-526 Modulation of K + Channels by G-Proteins....Pages 527-546 ATP-Sensitive K + Channel: Properties, Occurrence, Role in Regulation of Insulin Secretion....Pages 547-559 Modulation of Maxi-Calcium-Activated K Channels: Role of Ligands, Phosphorylation, and G-Proteins....Pages 561-579 Regulation of the Endosomal Proton Translocating ATPase (H + -ATPase) and Endosomal Acidification by G-Proteins....Pages 581-596 cAMP-Independent Regulation of Adipocyte Glucose Transport Activity and Other Metabolic Processes by a Complex of Receptors and Their Associated G-Proteins....Pages 597-609 Back Matter....Pages 611-618