Growth factors, peptides, and receptors [proceedings of the Twelfth Washington International Spring Symposium at the George Washington University, held June 1 - 5, 1992, in Washington, D.C

The Twelfth Annual Washington Spring Symposium on Health Sciences attracted over 300 scientists from 20 countries. It was held at the Lisner Auditorium of the George Washington University in Washington, D.C. during June 1-5, 1992. The theme of the meeting was "Growth Factors, Peptides, and Receptors," and speakers emphasized both basic and clinical research in these areas. The seven plenary sessions emphasized Peptides, Growth Factors, Peptide Receptors, Growth Factor Receptors, Second Messengers, Proliferation, and Clinical Correlations. The chapters in this volume are derived from each of these scientific sessions plus the poster and special sessions. The Abraham White Distinguished Scientist Award was presented to Dr. Solomon H. Snyder for his numerous contributions to the field of neurochemistry. He presented the keynote address "Nitric Oxide: A Novel Neuronal Messenger." Dr. Snyder discussed the pathway of nitric oxide (NO) synthesis by the enzyme NO synthase. Released NO may be responsible for the neuronal toxicity associated with NMDA, an excitatory amino acid analogue. Dr. Snyder noted that NO may be the first of a new class of transmitters, with carbon monoxide being another candidate. The Distinguished Public Service Award was presented to Senator Fritz Hollings in of his leadership and outstanding achievements in the United States Senate recognition and for his legislative support for biomedical research and education. In the symposium banquet address, Senator Hollings stressed the need for continued support of research to combat serious diseases such as cancer Front Matter....Pages i-x Front Matter....Pages 1-1 Distribution of Endothelin, a Putative Growth Promoting Peptide, Using Modern Microscopical Imaging Methods....Pages 3-13 Vasoactive Intestinal Peptide: From Molecular Genetics to Neurotropism....Pages 15-20 Design and Structure/Conformation-Activity Studies of a Prototypic Corticotropin-Releasing Factor (CRF) Antagonist: Multiple Alanine Substitutions of CRF 12-41 ....Pages 21-28 Retinoic Acid Regulates preproVIP Expression in the Human Neuroblastoma Cell Line NB-1....Pages 29-35 Structure-Dependent Inhibitory Effect of Galanin on Insulin, Gastric Acid and Pancreatic Amylase Secretion in Rat....Pages 37-50 Amphibian Opioids: Novel Dermorphin-Like Peptides....Pages 51-60 Proteases for Neuropeptide Precursor Processing in Bovine Adrenal Medullary Chromaffin Granules....Pages 61-70 Amylin and Neuromedin U - Two Novel Regulatory Peptides of the Gastroenteropancreatic System....Pages 71-79 Front Matter....Pages 81-81 Gene Transfer into the Central Nervous System: Neurotrophic Factors....Pages 83-91 The Structural and Biological Properties of Heparin-Binding Egf- Like Growth Factor (HB-EGF)....Pages 93-100 Structural Organization of the Multiple Tgf- ßGenes....Pages 101-113 Dexamethasone Modulates the Response of Rat Stromal Bone Marrow Derived Bone-Like Cells to bFGF and Igf-I....Pages 115-126 Behavioral, Hormonal and Neurochemical Alterations in Transgenic Mice Overexpressing Transforming Growth Factorα....Pages 127-136 Growth Factors and Brain Injury....Pages 137-146 The Basic Fibroblast Growth Factor Isoforms: Endogenous and Exogenous Behavior....Pages 147-158 Front Matter....Pages 159-159 Structural Analysis of Ligand Binding Characteristics for the Bombesin/Gastrin-Releasing Peptide Receptor....Pages 161-170 Identification of Zeta ( S ) Opioid Receptor Binding Polypeptides in Rat Cerebellum....Pages 171-180 Identification and Characterization of Somatostatin (SRIF), Gastrin Releasing Peptide (GRP), and Neuromedin B (NMB) Receptors on Established Tumors and Tumor Cell Lines....Pages 181-188 Neuropeptide Receptor Sub-Types: Neuropeptide Y and Calcitonin-Gene Related Peptides as New Examples....Pages 189-198 Vasoactive Intestinal Peptide and Astrocyte Mitogenesis: In Vitro and in Vivo Studies....Pages 199-210 Front Matter....Pages 159-159 Synthesis and Biological Activity of Cholecystokinin Antagonists....Pages 211-223 Peptide-Neuromedin B (NMB) Receptor Interactions: Comparison with Gastrin-Releasing Peptide (GRP) Receptor Interactions....Pages 225-237 Front Matter....Pages 239-239 Neurotrophins in the Adult Brain: Effects on Hippocampal Cholinergic Function Following Deafferentation, and Regulation of Their Expression by Pharmacological Agents and Lesions....Pages 241-253 Angiosuppressive and Antiproliferative Actions of Suramin: A Growth Factor Antagonist....Pages 255-264 [ 125 I]IGF I, [ 125 I]IGF II and [ 125 I]Insulin Receptor Binding Sites in the Rat Hippocampal Formation: Topographic Distribution and Response to Entorhinal Ablation....Pages 265-277 Estrogen Regulation of the Pituitary Insulin - Like Growth Factor System....Pages 279-288 Effects of Radiofrequency Radiation on Growth Factor Receptors....Pages 289-296 Structure-Function Analysis of Fibroblast Growth Factor-1 (Acidic Fibroblast Growth Factor)....Pages 297-308 Front Matter....Pages 309-309 MDGF-1: A New Tyrosine Kinase-Associated Growth Factor....Pages 311-322 Interleukin-11 Mediated Signal Transduction Pathways: Comparison With Those of Interleukin-6....Pages 323-333 Regulation of a Membrane Tyrosine Phosphatase by Somatostatin....Pages 335-339 Cycloheximide Has Differing Effects on Immediate Early Gene Expression in IL-3 or M-CSF Stimulated Human Monocytes....Pages 341-345 Regulation of Gastrin Releasing Peptide Gene Expression....Pages 347-352 TGFα Induced Proliferative Changes in Transgenic Mice....Pages 355-366 Somatostatin and Human Gastrointestinal Cancer....Pages 367-379 Inhibition by Gnrh Antagonists of Breast and Endometrial Cancer Cell Growth Induced by Estrogen and Insulin-Like Growth Factors....Pages 381-387 Front Matter....Pages 353-353 ß-Endorphin is Metabolized in Vitro by Human Small Cell Lung Cancer to γ-Endorphin Which Stimulates Clonal Growth....Pages 389-400 The Role of EGF and Its Receptors in the Growth of Human Gastric Carcinoma Cell Line (MGC80): Evidence for an Autocrine Mechanism....Pages 401-407 The Single-Chain Immunotoxins BR96 sFv-PE40 and BR96 sFv-PE38: Potent Anti-Tumor Agents for the Treatment of Human Cancer....Pages 409-414 Front Matter....Pages 415-415 Hematopoietic Cytokines to Support Repeated Doses of Dose-Intensive Chemotherapy with Cyclophosphamide, Etoposide, and Cisplatin (DICEP)....Pages 417-424 Front Matter....Pages 415-415 Interleukin-2 (IL-2) Augments the Expression of Transforming Growth Factor Beta in Patients with Disseminated Cancer....Pages 425-433 Peptide Signals for Satiety....Pages 435-443 The Role of Somatostatin Receptors in the Diagnosis and Therapy of Cancer....Pages 445-460 Back Matter....Pages 461-467 Proceedings of the XIIth Washington International Spring Symposium at George Washington University held in Washington, D.C., June 1-5, 1992