Growth Factors and Wound Healing: Basic Science and Potential Clinical Applications (Serono Symposia USA)

The biology of wound healing and tissue repair are increasingly being defined. At the same time, the availability of recombinant peptide growth factors for clinical investigation has prompted numerous trials of growth factor administration as adjunctive therapy to enhance the rate and quality of acute and chronic wound repair. New basic science information on growth factor function and regulation obtained in the research laboratory is actively being applied in animal studies and in clinical research settings. In addition to studies of surface wounds, an increasing number of investiga­ tions on growth factor administration have focused on healing and repair in nondermal tissues such as the intestinal tract and other organs. While the amount of new information on the molecular biology of growth factor expression, signaling, and function has been exponential in recent years, results of many clinical trials on growth factor administration in wound healing have been disappointing. This may be due, in part, to the heterogeneity of clinical wounds and the patients who harbor them, less than adequate standardization of care in experimental and control groups, issues related to drug dosing, and inadequate control for important issues relevant to healing such as nutrient intake and underlying nutritional status. Front Matter....Pages i-xviii Front Matter....Pages 1-1 An Overview of Wound Healing Biology....Pages 3-7 Growth Factors and Angiogenesis in Wound Healing....Pages 8-26 The Regulation of Basic Fibroblast Growth Factor (FGF-2) Through Limited Bioavailability....Pages 27-36 Cultured Skin Cells for Wound Closure and for Promoting Wound Healing....Pages 37-55 The Growth Hormone Insulin-Like Growth Factor-I Axis....Pages 56-76 Front Matter....Pages 77-77 Use of Exogenous Amino Acids in Wound Healing....Pages 79-91 Vitamin A-Growth Factor Interactions in Wound Healing....Pages 92-103 Interactions Between Nutrients and Growth Factors in Cellular Anabolism and Tissue Repair....Pages 104-147 Front Matter....Pages 149-149 Fibroblast Growth Factor Receptors....Pages 151-174 Arginine and Nitric Oxide (NO) Interactions in the Healing Wound....Pages 175-185 Endogenous Growth Factors and Nutrients in the Healing Wound....Pages 186-205 Epidermal Growth Factor in Wound Healing: A Model for the Molecular Pathogenesis of Chronic Wounds....Pages 206-228 Front Matter....Pages 229-229 Growth Hormone Therapy in Human Burn Injury....Pages 231-244 Effects of Exogenous Growth Hormone in Postoperative Immune Function and Other Clinical Outcomes....Pages 245-259 Effect of Growth Hormone Administration on Colonic Healing and Repair....Pages 260-280 Modulation of IGF-I Therapy by IGFBP-3: Potential Utility in Wound Healing....Pages 281-290 Front Matter....Pages 291-291 Roles of Keratinocyte Growth Factor in Epithelial Growth and Regeneration....Pages 293-303 Hepatocyte Growth Factor....Pages 304-316 The Biology of Vascular Endothelial Growth Factor, a Specific Regulator of Angiogenesis....Pages 317-332 FDA Regulatory Concerns for Wound Healing Biologics....Pages 333-343 Back Matter....Pages 345-365 This volume contains the proceedings of the International Symposium on Growth Factors and Wound Healing: Basic Science and Potential Clinical Applications, held in Boston from September 28-October 1, 1995. The objective of this symposium is to provide basic and clinical investigators state-of-the-art information on the biology of wound healing and tissue repair. Written and edited by eminent experts in the field, the papers herein cover the general concepts of wound healing; the role of nutrients in wound healing responses; endogenous growth factors and wound healing; clinical applications of growth hormone and IGF-1 therapy; and clinical applications of peptide growth factors The aim of this symposium was to provide basic and clinical investigators with the latest information on the biology of wound healing and tissue repair. endogenous growth factors; clinical applications of growth hormone and IGF-1 therapy; and clinical applications of peptide growth factors.