Goodman and Gilman's The Pharmacological Basis of Therapeutics, 14th Edition

This is the 14th edition of book that began as a collaboration betweentwo friends and professors at Yale, Louis Goodman and Alfred Gilman.Over the years, “G&G” has been acclaimed as the “blue bible” of pharmacology.Surely much of that acclaim reflects the book’s purpose, delineatedby the original authors and steadily adhered to over 81 years: tocorrelate pharmacology with related medical sciences, to reinterpret theactions and uses of drugs in light of advances in medicine and the basicbiomedical sciences, to emphasize the application of pharmacodynamicsto therapeutics, and to create a book that would be useful to students ofpharmacology and to healthcare practitioners.Following these principles is demanding: the sheer volume and unremittinggrowth of knowledge in the basic biomedical sciences and theirclinical applications continue to amaze, challenging editors and contributorswho are trying to produce a one-volume work, and surely challengingstudents. To create a book that reflects our times, we have updated allchapters and have added five new chapters: drug response and the gastrointestinalbiome, pharmacovigilance, the blood-brain barrier (it is notsimply a lipid sheath), cannabinoids, and immunotherapies for cancer,plus a novel appendix on drug-drug interactions. Advances in immunomodulationare presented in most sections. In addition, we have continuedto reach out to younger contributors who are on the forefront ofpharmacological investigation and clinical practice. As a result, we have,in this edition, 56 new contributors, drawn from diverse backgrounds,who will ensure the book’s vigor into the future. Cover Title Page Copyright Page Dedication Contents Contributors Preface Acknowledgments Section I General Principles 1. Drug Discovery: From Medicinal Plants to Computer-Aided Drug Design 2. Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimination 3. Pharmacodynamics: Molecular Mechanisms of Drug Action 4. Membrane Transporters and Drug Response 5. Drug Metabolism 6. The Gastrointestinal Microbiome and Drug Response 7. Pharmacogenetics and Pharmacogenomics 8. Postmarketing Drug Safety 9. Principles of Clinical Toxicology Section II Neuropharmacology 10. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems 11. Muscarinic Receptor Agonists and Antagonists 12. Anticholinesterase Inhibitors and Reactivators 13. Neuromuscular Junction and Autonomic Ganglia; Nicotine, Muscle Relaxants, and Spasmolytics 14. Adrenergic Agonists and Antagonists 15. 5-Hydroxytryptamine (Serotonin) and Dopamine 16. Neurotransmission in the Central Nervous System 17. The Blood-Brain Barrier and Its Influence on Drug Transport to the Brain 18. Drug Therapy of Depression and Anxiety Disorders 19. Pharmacotherapy of Psychosis and Mania 20. Pharmacotherapy of the Epilepsies 21. Treatment of Central Nervous System Degenerative Disorders 22. Hypnotics and Sedatives 23. Opioid Analgesics 24. General Anesthetics and Therapeutic Gases 25. Local Anesthetics 26. Cannabinoids 27. Ethanol 28. Drug Use Disorders and Addiction Section III Modulation of Pulmonary, Renal, and Cardiovascular 29. Drugs Affecting Renal Excretory Function 30. Renin and Angiotensin 31. Treatment of Ischemic Heart Disease 32. Treatment of Hypertension 33. Therapy of Heart Failure 34. Antiarrhythmic Drugs 35. Treatment of Pulmonary Arterial Hypertension 36. Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs 37. Drug Therapy for Dyslipidemias Section IV Inflammation, Immunomodulation, and Hematopoiesis 38. Introduction to Immunity and Inflammation 39. Immunosuppressants, Immunomodulation, and Tolerance 40. Immune Globulins and Vaccines 41. Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor 42. Pharmacotherapy of Inflammation, Fever, Pain, and Gout 43. Histamine, Bradykinin, and Their Antagonists 44. Pulmonary Pharmacology 45. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins Section V Endocrine Pharmacology 46. Introduction to Endocrinology: The Hypothalamic-Pituitary Axis 47. Thyroid and Antithyroid Drugs 48. Estrogens, Progestins, and the Female Reproductive Tract 49. Androgens and the Male Reproductive Tract 50. Adrenocorticotropic Hormone, Adrenal Steroids, and the Adrenal Cortex 51. Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus and Hypoglycemia 52. Agents Affecting Mineral Ion Homeostasis and Bone Turnover Section VI Gastrointestinal Pharmacology 53. Pharmacotherapy for Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease 54. Gastrointestinal Motility and Water Flux, Emesis, and Biliary and Pancreatic Disease 55. Pharmacotherapy of Inflammatory Bowel Disease Section VII Chemotherapy of Infectious Diseases 56. General Principles of Antimicrobial Therapy 57. DNA Disruptors: Sulfonamides, Quinolones, and Nitroimidazoles 58. Cell Envelope Disruptors: β-Lactam, Glycopeptide, and Lipopeptide Antibacterials 59. Miscellaneous Antibacterials: Aminoglycosides, Polymyxins, Urinary Antiseptics, Bacteriophages 60. Protein Synthesis Inhibitors 61. Antifungal Agents 62. Antiviral Agents (Nonretroviral) 63. Treatment of Viral Hepatitis (HBV/HCV) 64. Antiretroviral Agents and Treatment of HIV Infection 65. Chemotherapy of Tuberculosis and Nontuberculous Mycobacteria, Including Leprosy 66. Chemotherapy of Malaria 67. Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections 68. Chemotherapy of Helminth Infections Section VIII Pharmacotherapy of Neoplastic Disease 69. General Principles in the Pharmacotherapy of Cancer 70. Cytotoxics and Antimetabolites 71. Protein Kinase Inhibitors and Pathway-Targeted Small Molecules 72. Antibodies, CAR T Cells, and Proteins to Treat Cancer 73. Hormones, Hormone Receptor Antagonists, and Related Agents in the Therapy of Cancer Section IX Special Systems Pharmacology 74. Ocular Pharmacology 75. Dermatological Pharmacology 76. Environmental Toxicology Appendices I. Design and Optimization of Dosage Regimens: Pharmacokinetic Data II. Drug-Drug Interactions Index The landmark pharmacology reference―updated to reflect the latest research and developments in the field For more than 50 years, Goodman & Gilman’s: The Pharmacological Basis of Therapeutics has represented the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. The text's careful balance of basic science and clinical applications has guided thousands of health care practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing and treating disease. This Fourteenth Edition includes five new chapters, 600+ illustrations, and important content from 53 new contributors. More than a textbook, Goodman & Gilman’s is a working template for the effective and rational prescribing of drugs in daily practice. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, Fourteenth Edition features: Five NEW chapters on: -Pharmacovigilance -The blood-brain barrier -Cannabis -Antibodies, immune checkpoint inhibitors, CAR-T cells, and other biological agents -Gastrointestinal microbiome and drug response Expanded coverage of the use of genetic polymorphisms in designing appropriate therapies Revised and expanded chapter on pharmacodynamics and the molecular mechanisms of drug action 600+ color illustrations Drug Fact Tables summarizing clinical pharmacology Content Outline and Abbreviation List at the beginning of each chapter 50 NEW figures on mechanism of drug actions 53 NEW contributors NEW online updates A Doody's Core Title for 2023! The landmark pharmacology referenceupdated to reflect the latest research and developments in the field For more than 50 years,Goodman & Gilman The Pharmacological Basis of Therapeuticshas represented the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. The text's careful balance of basic science and clinical applications has guided thousands of health care practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing and treating disease. This Fourteenth Edition includes five new chapters, 600+ illustrations, and important content from 53 new contributors. More than a textbook, Goodman & Gilmans is a working template for the effective and rational prescribing of drugs in daily practice. Goodman & Gilman The Pharmacological Basis of Therapeutics, Fourteenth Edition Five NEW chapters blood-brain barrier-Cannabis-Antibodies, immune checkpoint inhibitors, CAR-T cells, and other biological agents-Gastrointestinal microbiome and drug responseExpanded coverage of the use of genetic polymorphisms in designing appropriate therapiesRevised and expanded chapter on pharmacodynamics and the molecular mechanisms of drug action600+ color illustrationsDrug Fact Tables summarizing clinical pharmacologyContent Outline and Abbreviation List at the beginning of each chapter50 NEW figures on mechanism of drug actions53 NEW contributorsNEW online updates "The first edition of this book appeared in 1941, the product of a collaboration between two friends and professors at Yale, Louis Goodman and Alfred Gilman. Their purpose, stated in the preface to that edition, was to correlate pharmacology with related medical sciences, to reinterpret the actions and uses of drugs in light of advances in medicine and the basic biomedical sciences, to emphasize the applications of pharmacodynamics to therapeutics, and to create a book that would be useful to students of pharmacology and to physicians. We continue to follow these principles"-- Provided by publisher