Golden Stage English

Well-written, readable, and superbly illustrated, Cellular and Molecular Immunology, 10th Edition, continues the tradition of excellence established through multiple editions of this bestselling text. Offering an unparalleled introduction to this complex field, it retains a practical, clinical focus while updating and revising all content to ensure clarity and comprehension, bringing readers fully up to date with new and emerging information in this challenging area. It’s an ideal resource for medical, graduate, and undergraduate students, as well as a trusted reference for physicians and scientists. Highlights the implications of immunologic science for the management of human disease, emphasizing clinical relevance throughout. Employs a highly accessible writing style that makes difficult concepts easier to understand, and provides clear implications of immunologic science to the management of human disease and clinical practice. Features updates from cover to cover, including new information on intracellular sensors of innate immunity, therapeutic use of monoclonal antibodies, regulation of migration events during T cell-B cell interactions, regulatory and transcriptional events in germinal center formation, immunology of infectious diseases including coronaviruses, human immunodeficiency disorders, and immunology of HIV. Provides a highly visual, full-color description of the key immunologic and molecular processes with a fully updated, comprehensive, and consistent art program, including many new and extensively revised illustrations. Helps readers grasp the details of experimental observations that form the basis for the science of immunology at the molecular, cellular, and whole-organism levels and draw the appropriate conclusions. Includes summary boxes that assist with rapid review and mastery of key material. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access multiple-choice questions that correspond to each chapter, plus all of the text, figures, and references from the book on a variety of devices. Instructions for online access Cover image Title page Table of Contents Copyright Dedication Preface Online Resources for Instructors and Students Chapter 1. Properties and Overview of Immune Responses Innate and Adaptive Immunity Innate Immunity Adaptive Immunity Summary Chapter 2. Cells and Tissues of the Immune System Cells of the Immune System Anatomy and Functions of Lymphoid Tissues Summary Chapter 3. Leukocyte Circulation and Migration Into Tissues Overview of Leukocyte Migration Adhesion Molecules on Leukocytes and Endothelial Cells Involved in Leukocyte Recruitment Chemokines and Chemokine Receptors Leukocyte-Endothelial Interactions and Leukocyte Recruitment into Tissues Migration of Neutrophils and Monocytes to Sites of Infection or Tissue Injury Migration and Recirculation of T Lymphocytes Migration of B Lymphocytes Summary Chapter 4. Innate Immunity Overview of Innate Immunity Recognition of Microbes and Damaged Tissue by the Innate Immune System Cellular Pattern Recognition Receptors Cellular Components of the Innate Immune System Soluble Effector Molecules of Innate Immunity The Inflammatory Response The Antiviral Response Stimulation of Adaptive Immunity Mechanisms that Limit Innate Immune Responses Summary Chapter 5. Antibodies and Antigens Antibody Structure Synthesis, Assembly, and Expression of Immunoglobulin Molecules Antibody Binding of Antigens Structure-Function Relationships in Antibody Molecules Summary Chapter 6. Antigen Presentation to T Lymphocytes and the Function of Major Histocompatibility Complex Molecules Properties of Antigens Recognized by T Lymphocytes Antigen Capture and the Functions of Antigen-Presenting Cells The Major Histocompatibility Complex Processing of Protein Antigens Presentation of Nonprotein Antigens to T Cells Summary Chapter 7. Immune Receptors and Signal Transduction Overview of Signal Transduction The Immune Receptor Family The T Cell Receptor Complex and T Cell Signaling The B Lymphocyte Antigen Receptor Complex The Attenuation of Immune Receptor Signaling Cytokine Receptors and Signaling Summary Chapter 8. Lymphocyte Development and Antigen Receptor Gene Rearrangement Overview of Lymphocyte Development Rearrangement of Antigen Receptor Genes in B and T Lymphocytes B Lymphocyte Development T Lymphocyte Development Summary Chapter 9. Activation of T Lymphocytes Overview of T Lymphocyte Activation Signals for T Lymphocyte Activation Functional Responses of T Lymphocytes Decline of T Cell Responses Summary Chapter 10. Differentiation and Functions of CD4+ Effector T Cells Overview of CD4+ T Cell–Mediated Immune Responses Subsets of CD4+ Effector T Cells The Th1 Subset The Th2 Subset The Th17 Subset Functions of Other HELPER T Cell Subsets Summary Chapter 11. Differentiation and Functions of CD8+ Effector T Cells Differentiation of CD8+ T Cells Into Cytotoxic T Lymphocytes Effector Functions of CD8+ Cytotoxic T Lymphocytes Cytokine Production by CD8+ Effector T Cells Roles of CD8+ Cytotoxic T Lymphocytes in Host Defense Summary Chapter 12. B Cell Activation and Antibody Production Overview of Humoral Immune Responses Antigen Recognition and Antigen-Induced B Cell Activation Helper T Cell–Dependent Antibody Responses to Protein Antigens Antibody Responses to T-Independent Antigens Antibody Feedback: Regulation of Humoral Immune Responses By Fc Receptors Summary Chapter 13. Effector Mechanisms of Humoral Immunity Overview of Humoral Immunity Neutralization of Microbes and Microbial Toxins Antibody-Mediated Opsonization and Phagocytosis The Complement System Summary Chapter 14. Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues General Features of Immunity at Epithelial Barriers Immunity in the Gastrointestinal System Immunity in Other Mucosal Tissues The Cutaneous Immune System Immune-Privileged Tissues Immunity in the Mammalian Fetus and Newborn Summary Chapter 15. Immunologic Tolerance and Autoimmunity Overview of Immunologic Tolerance T Lymphocyte Tolerance B Lymphocyte Tolerance Tolerance to Commensal Microbes and Other Foreign Antigens Mechanisms of Autoimmunity Summary Chapter 16. Immunity to Microbes Overview of Immune Responses to Microbes Immunity to Extracellular Bacteria Immunity to Intracellular Bacteria Immunity to Fungi Immunity to Viruses Immunity to Parasites Strategies for Vaccine Development Summary Chapter 17. Transplantation Immunology General Principles of Transplantation Immunology Immune Responses to Allografts Patterns and Mechanisms of Allograft Rejection Prevention and Treatment of Allograft Rejection Xenogeneic Transplantation Blood Transfusion and the Abo and Rh Blood Group Antigens Hematopoietic Stem Cell (HSC) Transplantation Summary Chapter 18. Tumor Immunology Overview of Tumor Immunity Tumor Antigens Immune Responses To Tumors Evasion of Immune Responses by Tumors Immunotherapy For Tumors Summary Chapter 19. Hypersensitivity Disorders Causes of Hypersensitivity Diseases Mechanisms and Classification of Hypersensitivity Reactions Diseases Caused by Antibodies and Antigen-Antibody Complexes Diseases Caused by T Lymphocytes Therapeutic Approaches for Immunologic Diseases Selected Immunologic Diseases: Pathogenesis and Therapeutic Strategies Summary Chapter 20. Allergy Overview of IgE-Dependent Allergic Reactions Production of IgE Cells Involved in Allergic Reactions Reactions Dependent on IgE and Mast Cells Genetic Susceptibility to Allergic Disease Allergic Diseases in Humans: Pathogenesis and Therapy The Protective Roles of Immune Reactions Mediated by IgE and Mast Cells Summary Chapter 21. Primary and Acquired Immunodeficiencies Overview of Immunodeficiency Diseases Primary (Congenital) Immunodeficiencies Secondary (Acquired) Immunodeficiencies Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome Summary Glossary Appendix I. Principal Features of Selected CD Molecules Appendix II. Cytokines Appendix III. Laboratory Techniques Commonly Used in Immunology Index Well-written, readable, and superbly illustrated, Cellular and Molecular Immunology, 10th Edition, continues the tradition of excellence established through multiple editions of this bestselling text. Offering an unparalleled introduction to this complex field, it retains a practical, clinical focus while updating and revising all content to ensure clarity and comprehension, bringing readers fully up to date with new and emerging information in this challenging area. It’s an ideal resource for medical, graduate, and undergraduate students, as well as a trusted reference for physicians and scientists. Highlights the implications of immunologic science for the management of human disease, emphasizing clinical relevance throughout. Employs a highly accessible writing style that makes difficult concepts easier to understand, and provides clear implications of immunologic science to the management of human disease and clinical practice. Features updates from cover to cover, including new information on intracellular sensors of innate immunity, therapeutic use of monoclonal antibodies, regulation of migration events during T cell-B cell interactions, regulatory and transcriptional events in germinal center formation, immunology of infectious diseases including coronaviruses, human immunodeficiency disorders, and immunology of HIV. Provides a highly visual, full-color description of the key immunologic and molecular processes with a fully updated, comprehensive, and consistent art program, including many new and extensively revised illustrations. Helps readers grasp the details of experimental observations that form the basis for the science of immunology at the molecular, cellular, and whole-organism levels and draw the appropriate conclusions. Includes summary boxes that assist with rapid review and mastery of key material. Evolve Instructor site with an image and test bank is available to instructors through their Elsevier sales rep or via request at https://evolve.elsevier.com.