Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins (Springer Theses)

This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling. Front Matter ....Pages i-xxxix Front Matter ....Pages 1-1 Au(I)-Phosphine Series Design (Raphael Enoque Ferraz de Paiva)....Pages 3-43 Probing the Protein: Ion Mobility Spectrometry (Raphael Enoque Ferraz de Paiva)....Pages 45-56 Probing Gold: X-Ray Absorption Spectroscopy (Raphael Enoque Ferraz de Paiva)....Pages 57-74 Probing Cells: Evaluating Cytotoxicity (Raphael Enoque Ferraz de Paiva)....Pages 75-90 Front Matter ....Pages 91-91 Au(III) Series with κ2C,N and κ2N,N′ Ligands (Raphael Enoque Ferraz de Paiva)....Pages 93-130 “Dual-Probe” X-Ray Absorption Spectroscopy (Raphael Enoque Ferraz de Paiva)....Pages 131-151