Glycoscience: Synthesis Of Substrate Analogs And Mimetics Synthesis Of Substrate Analogs And Mimetics

The synthesis of very complex saccharide structures is one of the most challenging areas of modern glycoscience. This volume presents the state of the art of complex carbohydrate synthesis, written by leading scientists whose groups are making major contributions in the field. Reflecting the particular interest in inhibitors and modulators as well as in mimetics, an in-cepth treatment is given both of their selective syntheses and of their biological implications. In addition the concept of multivalent glycoconjugate recognition as well as supramolecular implications of amphiphilic carbohydrates are highlighted. Nucleophilic C-glycosyl Donors For C-glycoside Synthesis / J.-m. Beau And T. Gallagher -- Synthesis Of C-glycosides Of Biological Interest / F. Nicotra -- Thiooligosaccharides In Glycobiology / H. Driguez -- Aldonolactones As Chiral Synthons / I. Lundt -- Chemical And Chemo-enzymatic Approaches To Glycosidase Inhibitors With Basic Nitrogen In The Sugar Ring / A. De Raadt [and Others] -- The Synthesis Of Novel Enzyme Inhibitors And Their Use In Defining The Active Sites Of Glycan Hydrolases / R.v. Stick -- Heparinoid Mimetics / H.p. Wessel -- Recent Development In The Rational Design Of Multivalent Glycoconjugates / R. Roy -- Amphiphilic Carbohydrates As A Tool For Molecular Recognition In Organized Systems / P. Boullanger -- Preface / H. Driguez And J. Thiem. Volume Editors, H. Driguez, J. Thiem ; With Contributions By J.m. Beau ... [et Al.]. Includes Bibliographical References And Index. This volume presents the state of the art of complex carbohydrate synthesis. Reflecting the particular interest in inhibitors and modulators as well as in mimetics, an in-depth treatment is given both of their selective syntheses and of their biological implications.