Glycoscience : basic science to applications : insights from the Japan Consortium for Glycobiology and Glycotechnology (JCGG)

"This book presents the state of the art in glycoscience and proposes a road map for the coming decade, focusing on the potential of glycoscience research to shed light on important basic science issues and give rise to exciting new applications, especially in the field of diagnosis and therapeutics. Individual sections offer in-depth coverage of various topics relating to glycans and biopharmaceuticals, glycans in medical science and medicine, glycan technologies, glycans in food and nutrients, and glycan-related materials and their uses. In addition, the book presents an exemplary training course on glycomics and highlights educational and analytical web resources, and also includes glossaries and boxes summarizing key facts to ensure ease of understanding for non-expert readers and students. Written by more than 150 active participants in the Japan Consortium for Glycobiology and Glycotechnology (JCGG), whose goal is to promote the development of interdisciplinary glycoscience and establish a global network in the field, it is a valuable resource for students, postdocs, and researchers in the life sciences as well as for stakeholders and professionals in government, funding agencies and industry." -- prové de l'editor Front Matter ....Pages i-xv Front Matter ....Pages 1-1 Structural Analysis of Glycans (Analytical and Detection Methods) (Kazuki Nakajima, Kazuo Takahashi, Yoshiki Yamaguchi, Yasuro Shinohara, Hiroyuki Kaji, Jun-ichi Furukawa et al.)....Pages 3-33 Structural Biology of Glycans (Chikara Sato, Koichi Kato, Yoshiki Yamaguchi, Daisuke Kohda, Ryuichi Kato, Kenichi G. N. Suzuki et al.)....Pages 35-63 Chemical and Enzymatic Synthesis and Production of Glycans (Yukishige Ito, Toshiki Nokami, Yasuhiro Kajihara, Ichiro Matsuo, Hideharu Ishida, Hiromune Ando et al.)....Pages 65-86 Technologies to Elucidate Functions of Glycans (Koichi Furukawa, Yuhsuke Ohmi, Yuji Kondo, Yuki Ohkawa, Orie Tajima, Keiko Furukawa et al.)....Pages 87-124 Front Matter ....Pages 125-125 Antibody Pharmaceuticals (Nana Kawasaki, Noritaka Hashii)....Pages 127-131 Standard Glycan Library (Shin-ichi Nakakita)....Pages 133-135 Mass Production in Silk Worm and Yeast (Yasunori Chiba, Masahiro Tomita, Yoshitaka Ikeda)....Pages 137-143 Glycoengineering (Yasuhiro Kajihara, Kenji Yamamoto, Mitsuo Satoh, Shino Manabe, Tatsuya Oda, Osamu Shimomura et al.)....Pages 145-166 Glycomimetics (Hiroto Kawashima, Takeshi Tsubata, Yoichiro Arata, Jin-ichi Inokuchi, Yasuhiko Kizuka, Shino Manabe)....Pages 167-178 Glycan Vaccine (Tsukasa Seya, Sho Yamasaki, Koichi Fukase)....Pages 179-187 Front Matter ....Pages 189-190 Glycan Function in Development and its Regulation (Shoko Nishihara, Masashi Toyoda, Yasuhiko Kizuka, Yuki I. Kawamura, Miyako Nakano, Yoshimi Haga et al.)....Pages 191-207 Glycans in Nervous System (Chihiro Sato, Jianguo Gu, Tomohiko Fukuda, Kenji Kadomatsu, Kazuhiro Ikenaka)....Pages 209-219 Glycans in Osseous Tissue and Articulation (Tadahisa Mikami, Hiroshi Kitagawa, Norimasa Iwasaki)....Pages 221-226 Glycans in Infection and Immunity (Takashi Suzuki, Masatoshi Okamatsu, Yoshihiro Sakoda, Taroh Kinoshita, Takane Katayama, Hiroshi Kiyono et al.)....Pages 227-257 Next Generation Medical Care (Yuzuru Ikehara, Eiji Miyoshi, Yasuhiko Kizuka, Yoshiki Yamaguchi)....Pages 259-267 Life-Style Related Disease and Aging (Kazuaki Ohtsubo, Yasuhiko Kizuka, Naoyuki Taniguchi, Motoko Takahashi, Katsuhiko Yanagisawa, Shinobu Kitazume et al.)....Pages 269-288 Congenital Disorders of Glycosylation (CDG), Neuromuscular Related Diseases (Yoshinao Wada, Tadashi Suzuki, Tamao Endo)....Pages 289-295 Glycan Biomarkers for Cancer and Various Disease (Atsushi Kuno, Eiji Miyoshi, Jun Nakayama, Chikara Ohyama, Akira Togayachi)....Pages 297-309 Front Matter ....Pages 311-311 Food Implicated in Glycans and its Function (Masaaki Tokuda, Sayuri Akuzawa, Tadasu Urashima, Yoshinobu Kimura, Teruko Konishi)....Pages 313-326 Front Matter ....Pages 327-327 Glycan-related Materials and their use for Biomaterials (Hiroyuki Yano, Shinsuke Ifuku, Jun-ichi Kadokawa, Akira Harada, Shin-ichiro Shoda, Kazunari Akiyoshi et al.)....Pages 329-351 Front Matter ....Pages 353-353 Educational Materials and Training for Glycosciences (Eriko Hagiya, Daisuke Shinmachi, Jun Hirabayashi, Kiyoko F. Aoki-Kinoshita, Issaku Yamada)....Pages 355-368 Back Matter ....Pages 369-405