Glycobiology and Medicine: Proceedings of the 7th Jenner Glycobiology and Medicine Symposium. (Advances in Experimental Medicine and Biology, 564)

The potential for glycobiology to improve the practice of medicine has been well recognised, which is why biannual meetings concerning the association have been taking place for the last 14 years. The science of glycobiology has matured rapidly, and with it the far reaching clinical implications are becoming understood. The next decade is going to see this final frontier of science conquered. The impact this understanding of glycobiology will have upon our practice of medicine is going to be exciting. The 7th Jenner Glycobiology and Medicine Symposium was designed to reflect these advances. All the major clinical areas were involved, with contributions from pivotal players in science and medicine. Glycosylation: Disease Targets and Therapy....Pages 1-2 Long Alkylchain Iminosugars Block the HCV p7 Ion Channel....Pages 3-4 The Bovine Viral Diarrhoea Virus: A Model for the Study of Antiviral Molecules Interfering with N-Glycosylation and Folding of Enveloppe Glycoprotein....Pages 5-6 Antibody Recognition of a Carbohydrate Epitope: A Template for HIV Vaccine Design....Pages 7-8 Interaction of Schistosome Glycans with the Host Immune System....Pages 9-19 The Mannan-Binding Lectin (MBL) Pathway of Complement Activation: Biochemistry, Biology and Clinical Implications....Pages 21-22 Killer Cell Lectin-Like Receptors and the Natural Killer Cell Gene Complex....Pages 23-24 Glycosylation Influences the Ligand Binding Activities of Mannose Receptor....Pages 25-26 Human Immunoglobulin Glycosylation and the Lectin Pathway of Complement Activation....Pages 27-43 Gelatinase B Participates in Collagen II Degradation and Releases Glycosylated Remnant Epitopes in Rheumatoid Arthritis....Pages 45-55 Hyaluronan in Immune Processes....Pages 57-69 Glycosylation and the Function of the T Cell Co-Receptor CD8....Pages 71-84 Immunogenicity of Calreticulin-Bound Murine Leukemia Virus Glycoprotein gp90....Pages 85-94 Glycosylation and GPI Anchorage of the Prion Protein....Pages 95-96 Glycosylation Defects and Muscular Dystrophy....Pages 97-98 Roles of Complex and Hybrid N -Glycans and O -Fucose Glycans in Oocyte Development and Function....Pages 99-100 Mucin Oligosaccharides and Pigeon Fanciers’ Lung....Pages 101-102 Differential Glycosylation of Gelatinase B from Neutrophils and Breast Cancer Cells....Pages 103-112 Detection of Glycosylation Changes in Serum and Tissue Proteins in Cancer by Lectin Blotting....Pages 113-114 Carbohydrates and Biology of Staphylococcal Infections....Pages 115-116 New Developments in Treating Glycosphingolipid Storage Diseases....Pages 117-126 Fucosylated Glycans in Innate and Adaptive Immmunity....Pages 127-128 New Insights into Rheumatoid Arthritis Associated Glycosylation Changes....Pages 129-138 Production of Complex Human Glycoproteins in Yeast....Pages 139-139 Relationships Between the N-Glycan Structures and Biological Activities Of Recombinant Human Erythropoietins Produced Using Different Culture Conditions and Purification Procedures....Pages 141-142 Glycosylation of Natural and Recombinant Antibody Molecules....Pages 143-148 7th Jenner Glycobiology and Medicine Symposium Sunday5W Wednesday 8 September 2004 John S. Axford StGeorges, University of London, UK The potential for glycobiology to improve the practice of medicine has been well recognised, which is why biannual meetings concerning the association have been taking place for the last 14 years. The science of glycobiology has matured rapidly, and with it the far reaching clinical implications are becoming understood. The next decade is going to see this ?nal frontier of science conquered. The impact this understanding of glycobiology will have upon our practice of medicine is going to be exciting. The 7th Jenner Glycobiology and Medicine Symposium was designed tore?ecttheseadvances.Allthemajorclinicalareaswereinvolved,withcontributions from pivotal players in science and medicine. As with our previous meetings, junior scientists were involved as we recognise that at the end of the next decade they will be in the driving seat. This introduction serves as a taster to whet your appetite. From embryogenesis to pathogenesis, glycosylation plays a pivotal role. Complex and hybrid N-glyans and O-fucose glycans are critical in oocyte devel- ment and function. This area must surely be a fertile ground for glycosylation research. Edited By John S. Axford. 7th Jenner Glycobiology And Medicine Symposium Sunday 5 - Wednesday 8 September 2004--p. V. Includes Bibliographical References And Index.