Glycobiology And Medicine (advances In Experimental Medicine And Biology)

This book contains the Proceedings of the Sixth Jenner Glycobiology and Medicine Symposium, held 14-17 September, 2002, in Seillac, France. This book highlights the latest developments in glycoimmunology, including glycosylation-dependent bacterial and viral infections, lectin and proteoglycan-dependent interactions in leukocyte homing processes to lymphoid tissues and inflamed tissues, congenital defects in glycosylation of glycoproteins and glycolipids, and the role of carbohydrates in tumour development and neuropathology, including Creutzfeldt-Jakob disease. Front Matter....Pages i-viii Front Matter....Pages 1-1 A Sweet Coating—How Bacteria Deal with Sugars....Pages 3-15 The Glycosylation of Airway Mucins in Cystic Fibrosis and its Relationship with Lung Infection by Pseudomonas aeruginosa ....Pages 17-32 Structural Basis for Bacterial Adhesion in the Urinary Tract....Pages 33-52 Front Matter....Pages 53-53 Crystal Structure of an Intact Human IgG: Antibody Asymmetry, Flexibility, and a Guide for HIV-1 Vaccine Design....Pages 55-66 Front Matter....Pages 67-67 Remnant Epitopes Generate Autoimmunity: From Rheumatoid Arthritis and Multiple Sclerosis to Diabetes....Pages 69-77 Endothelial Cell Glycosylation: Regulation and Modulation of Biological Processes....Pages 79-94 Involvement of Gags in the Activity of Pro-Inflammatory Factors....Pages 95-106 Lectin Domains on Cytokines....Pages 107-124 Cytokines and Glycosaminoglycans (GAGS)....Pages 125-143 Front Matter....Pages 145-145 Thomsen-Friedenreich Antigen: The “Hidden” Tumor Antigen....Pages 147-162 Glycodynamics of Mucin Biosynthesis in Gastrointestinal Tumor Cells....Pages 163-188 O -GlcNAc Glycosylation and Neurological Disorders....Pages 189-202 Front Matter....Pages 203-203 The Carbohydrate Epitope of the Neutralizing Anti-HIV-1 Antibody 2G12....Pages 205-218 New Therapeutics for the Treatment of Glycosphingolipid Lysosomal Storage Diseases....Pages 219-226 Front Matter....Pages 227-227 The Mannose-Binding Lectin (MBL) Route for Activation of Complement....Pages 229-250 Anti-Inflammatory Properties of Specific Glycoforms of Human α 1 -Acid Glycoprotein....Pages 251-256 The Glycosylation of Tyrosinase in Melanoma Cells and the Effect on Antigen Presentation....Pages 257-269 Glycobiology of the Rheumatic Diseases: An Update....Pages 271-280 Back Matter....Pages 281-292